2010 Gordon Res Conference on Epilepsy & Mechanisms of Neuronal Synchronization

2010 年戈登研究癫痫会议

• 批准号: 7901255
• 负责人: John R Huguenard
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-08 至 2010-08-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901255
• 关键词: Affect; Behavior; Biological; Chronic; Collaborations; Development; Environment; Epigenetic Process; Epilepsy; Epileptogenesis; Failure; Fostering; Future; Gene Expression Regulation; Gene Structure; Generations; Goals; Homeostasis; Ion Channel; Knowledge; Maine; MicroRNAs; Molecular; National Institute of Neurological Disorders and Stroke; Neurons; Proteins; Research; Scientific Advances and Accomplishments; Seizures; Staging; Stem cells; Synapses; Time; Work; base; college; inhibitory neuron; insight; neural circuit; neuroinflammation; novel; novel therapeutics; public health relevance; symposium; translational study

DESCRIPTION (provided by applicant): We are requesting NINDS support for a Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization to be held August 8-13, 2010 at Colby College in Maine. The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks in order to develop more effective and less toxic treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, electrophysiologists, and computational neuroscientists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and set the stage for future discoveries. The theme of the current conference is Neural Circuits and Epilepsy, and topics to be covered include: Microcircuit Dynamics: Emergence of synchrony; Inhibitory neurons: failure to deliver; Neuroinflammation and Epilepsy; Circuit Homeostasis: Analytical and Experimental approaches in Epilepsy; Epigenetics, gene regulation and microRNAs in Epilepsy; Circuit development and function: basis for epileptic networks; Stem Cells and Epilepsy; Epileptogenesis: occult and overt mechanisms; and Epileptic ion channels and synaptic proteins. Our goals are to disseminate the latest scientific advances, foster productive new insights and collaborations, and set the stage for new translational studies that will bring the newest discoveries to the bedside in the shortest possible time. PUBLIC HEALTH RELEVANCE: Epilepsy is a chronic condition that affects 50 million people worldwide. Development of novel therapeutic strategies to better treat and potentially cure this devastating condition requires scientific advances to better understand the molecular and cellular mechanisms responsible for epilepsy. This conference will bring together experts from all over the world in an intensive, immersive environment to present and discuss novel findings, facilitating dissemination of knowledge and spawning collaborations. This should significantly advance research directed towards better treatment of epilepsy.

描述（由申请人提供）：我们要求NINDS支持戈登的癫痫机制和神经元同步研究会议，将于2010年8月8日至13日在缅因州的科尔比学院举行。癫痫发作研究的主要目的是确定神经元网络中同步电气放电的机制，以开发出更有效，更少的毒性治疗方法和癫痫病的治疗方法。癫痫研究的独特，智力上具有挑战性的方面源于以下事实：它几乎涵盖了从基因和离子渠道到电路和行为的几乎所有主要级别的生物组织。这次戈登会议的主要目的是将遗传学家，分子生物学家，发育神经科学家，神经解剖学家，电生理学家以及计算神经科学家直接或间接地与癫痫发作相关的基本机制，以综合当前发现并为未来的发现建立舞台。当前会议的主题是神经回路和癫痫，涵盖的主题包括：微电路动力学：同步的出现；抑制性神经元：未交付；神经炎症和癫痫；电路稳态：癫痫的分析和实验方法；癫痫中的表观遗传学，基因调节和microRNA；电路开发和功能：癫痫网络的基础；干细胞和癫痫；癫痫发生：神秘和明显的机制；和癫痫离子通道和突触蛋白。我们的目标是传播最新的科学进步，促进生产力的新见解和合作，并为新的翻译研究奠定了基础，这些研究将在最短的时间内将最新的发现带到床边。 公共卫生相关性：癫痫是一种慢性病，影响了全球5000万人。开发新的治疗策略以更好地治疗和潜在地治疗这种毁灭性的状况需要科学进步，以更好地理解负责癫痫的分子和细胞机制。这次会议将在密集，身临其境的环境中汇集来自世界各地的专家，以呈现和讨论新颖的发现，从而促进知识和产卵合作的传播。这应该大大提高针对更好地治疗癫痫的研究。