Pathology of the Inner Ear: Mechanisms and Treatment

内耳病理学：机制和治疗

• 批准号: 8006310
• 负责人: RICHARD A ALTSCHULER
• 金额: $ 1.86万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006310
• 关键词: Animal Experiments; Area; Arts; Auditory; Awareness; Basic Science; Clinic; Clinical; Clinical Trials; Cochlear Implants; Collaborations; Communities; Consensus; Development; Discipline; Fertilization; Future; Goals; Hearing; Labyrinth; Molecular; Molecular Medicine; Noise-Induced Hearing Loss; Pathology; Pharmaceutical Preparations; Prevention; Preventive Intervention; Publications; Rehabilitation therapy; Research; Research Personnel; Students; Time; Translational Research; Translations; base; career; commercial application; effective intervention; inner ear diseases; meetings; multidisciplinary; novel; posters; public health relevance; symposium

DESCRIPTION (provided by applicant): In the last decade we have witnessed exciting advances in the prevention and rehabilitation of otopathologies. An increased understanding of underlying mechanisms is rapidly leading to the development of novel and effective interventions. For the first time, clinical trials on the prevention of drug- and noise-induced hearing loss have either been recently concluded or are under way. The most effective current rehabilitation, cochlear prostheses, has matured and is expanding to new horizons, while alternate treatment paradigms, involving molecular medicine, begin to show promise in animal experiments. It is therefore timely to have a meeting bringing together basic, translational and clinical researchers as well as clinicians to critically review these developments and look to the future. We propose a two day meeting with platform presentations, posters and time for formal and informal discussions to: 1) Provide an understanding of molecular mechanisms underlying widespread and unresolved otopathologies; 2) analyze these mechanisms for common themes as well as differences; 3) explore how an understanding of basic principles can be used to develop targeted treatments; 4) familiarize researchers and clinicians with each others' goals and problems, 5) discuss opportunities to accelerate the translation of basic research to the clinic and 6) create awareness in students, residents and trainees about inner ear disorders and the state of the art of research and clinical endeavors to establish a basis for future careers and collaborations. A primary objective of this conference is to increase the dialogue and cross-fertilization across disciplines and pathologies. The speakers, therefore, represent and will present basic research, translational research and clinical considerations. Furthermore, in addition to a multidisciplinary presentation of recent and relevant results, a purpose of the meeting will be to encourage discussions with the wider auditory, vestibular and clinical community, for which the poster sessions will be an appropriate vehicle. Together with a later publication of reviews and articles by speakers and selected poster presenters in a special issue of Hearing Research, the conference will identify areas of consensus and disagreement, generate new ideas and areas for future development, provide opportunity for cooperation and stimulate translation of research results to clinical and even potential commercial application. PUBLIC HEALTH RELEVANCE: Recent developments in our understanding of the mechanisms underlying some of the most common inner ear pathologies, their prevention and their treatment have made it timely to have a meeting bringing together basic, translational and clinical researchers as well as clinicians to critically review these developments and look to the future. We propose a two day meeting to provide an understanding of molecular mechanisms, to analyze mechanisms for common themes across different inner ear pathologies as well as differences and to examine developments in targeted interventions for prevention and treatment across inner ear disorders.

描述（由申请人提供）：在过去的十年中，我们见证了耳病理学的预防和康复方面令人兴奋的进展。对潜在机制的加深了解正在迅速导致新颖且有效的干预措施的发展。预防药物和噪音引起的听力损失的临床试验最近已经完成或正在进行中，这还是第一次。目前最有效的康复方法——人工耳蜗，已经成熟并正在扩展到新的领域，而涉及分子医学的替代治疗模式开始在动物实验中显示出希望。因此，现在是时候召开一次会议，将基础研究人员、转化研究人员和临床研究人员以及临床医生聚集在一起，批判性地审查这些进展并展望未来。 我们建议举行为期两天的会议，包括平台演示、海报以及正式和非正式讨论的时间，以： 1) 提供对广泛且未解决的耳病理学背后的分子机制的理解； 2）分析这些机制的共同点和差异； 3）探索如何利用对基本原理的理解来开发有针对性的治疗方法； 4) 让研究人员和临床医生熟悉彼此的目标和问题，5) 讨论加速基础研究转化为临床的机会，6) 提高学生、住院医生和受训人员对内耳疾病和最新技术水平的认识研究和临床努力为未来的职业和合作奠定基础。 本次会议的主要目标是加强跨学科和病理学的对话和交叉交流。因此，演讲者代表并将介绍基础研究、转化研究和临床考虑。此外，除了对最近的相关结果进行多学科介绍外，会议的目的还在于鼓励与更广泛的听觉、前庭和临床界进行讨论，海报会议将是一个适当的载体。会议将与随后在《听力研究》特刊上发表演讲者和选定的海报展示者的评论和文章一起，确定共识和分歧领域，为未来发展产生新的想法和领域，提供合作机会并促进翻译研究成果应用于临床甚至潜在的商业应用。 公共卫生相关性：我们对一些最常见内耳病理的机制、其预防和治疗的理解的最新进展，使得我们及时召开一次会议，将基础、转化和临床研究人员以及临床医生聚集在一起，进行严格审查这些发展并展望未来。我们建议召开为期两天的会议，以了解分子机制，分析不同内耳病理的共同主题和差异的机制，并检查预防和治疗内耳疾病的针对性干预措施的进展。