Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources

灵活的混合云基础设施，可无缝管理 HuBMAP 资源

• 批准号: 10017372
• 负责人: Philip D. Blood
• 金额: $ 50万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2022-06-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017372
• 关键词: 3-Dimensional; Architecture; Atlases; Award; BRAIN initiative; Blood; Brain imaging; Budgets; Cancer Research Network; Cells; Censuses; Centers for Disease Control and Prevention (U.S.); Chicago; Cloud Computing; Collection; Complex; Computer software; Data; Data Science; Data Set; Deposition; Ensure; FAIR principles; FaceBase; Goals; Grant; Health Technology; Human; Human body; Hybrids; Image; Imagery; Infrastructure; Institutes; Lead; Leadership; Licensing; Maps; National Heart, Lung, and Blood Institute; National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; Output; Participant; Philosophy; Process; Recording of previous events; Reproducibility; Research; Resources; Role; Running; Scientist; Security; Services; Site; Site Visit; Solid; Structure; Supercomputing; System; Technology; Time; Tissues; United States National Institutes of Health; Universities; Vision; Work; base; collaboratory; computing resources; cost; cyber infrastructure; data management; data resource; data sharing; design; experience; flexibility; image archival system; imaging scientist; open data; peer networks; programs; social; software development; tool; tumor; usability; user centered design; virtual

To provide for the Infrastructure Component (IC) of the HuBMAP HIVE, Pittsburgh Supercomputing Center (PSC) and the University of Pittsburgh (Pitt) will create a flexible and scalable hybrid cloud infrastructure in close coordination with the HIVE Collaboratory, the HuBMAP Consortium, and stakeholders world wide. This proposed IC will seamlessly connect HuBMAP with storage and co-located compute resources for depositing, accessing, querying, searching, analyzing, and visualizing both raw and processed HuBMAP data. Data and tools incorporated into the IC will be findable, accessible, interoperable, reusable (FAIR), and put together in reproducible, shareable workflows that can be run locally and on all major public clouds. The IC services will be flexible and extensible to incorporate new data, tools, technologies, security needs, federated identity and user roles via modular architecture of APIs and containers. These features enable tools to be both rapidly deployed and modifiable, defined as distinct functions with defined inputs and outputs, enabling solidly constructed repeatable pipelines. The IC will provide the open data platform for study of tissue organization and function through 3D biomolecular tissue maps in the spatial framework of the human body envisioned by HuBMAP. Our vision for the HuBMAP infrastructure is flexible, efficient delivery on HuBMAP’s goals, on sustainable platforms, by engaged and experienced leadership. We see the infrastructure component in a key service role to other HIVE components, TMCs, NIH program, and interacting with other atlas projects. Our design is based upon existing substantial persistent infrastructure supported by many projects with a 30-year history. At PSC, HuBMAP will be sustained for decades at reasonable cost and/or integrate with other programs. In addition to leadership and grounded technology expertise, we are proposing full-time project management and imaging and data science expertise within our team. These capabilities will allow the infrastructure component staff to engage as “ever-present” participants in any aspects of the discussions of the integrated collaboratory conceived by the HuBMAP program (e.g. HIVE, TMCs, NIH staff). The structure of the HIVE enables the infrastructure component to focus on delivery and the engagement required for delivery.

为匹兹堡超级计算中心 HuBMAP HIVE 提供基础设施组件 (IC) （PSC）和匹兹堡大学（Pitt）将紧密合作创建灵活且可扩展的混合云基础设施 与 HIVE 合作实验室、HuBMAP 联盟和世界各地的利益相关者进行协调。 IC 将 HuBMAP 与存储和共置计算资源无缝连接，用于存储、访问、 查询、搜索、分析和可视化原始和处理后的 HuBMAP 数据和工具。 集成到 IC 中的将是可查找、可访问、可互操作、可重用（公平）的，并放在一起 可在本地和所有主要公共云上运行的可复制、可共享的工作流程。 灵活且可扩展，可合并新数据、工具、技术、安全需求、联合身份和用户 这些功能使工具能够快速部署。 并且可修改，定义为具有定义的输入和输出的不同功能，从而能够牢固构建 可重复的管道将为组织组织和功能的研究提供开放数据平台。 通过 HuBMAP 设想的人体空间框架中的 3D 生物分子组织图。 我们对 HuBMAP 基础设施的愿景是灵活、高效地实现 HuBMAP 的目标以及可持续发展 我们认为基础设施组件发挥着关键的服务作用。 我们的设计基于其他 HIVE 组件、TMC、NIH 计划以及与其他 Atlas 项目的交互。 存在于 PSC 拥有 30 年历史的许多项目支持的大量持久基础设施之上。 HuBMAP 将以合理的成本维持数十年和/或与其他项目整合。 领导力和扎实的技术专业知识，我们建议全职项目管理和成像以及 我们团队中的数据科学专业知识将使基础设施部门的员工能够参与进来。 作为“永远存在”的参与者参与由 HuBMAP 计划（例如 HIVE、TMC、NIH 工作人员） HIVE 的结构支持基础设施组件。 专注于交付和交付所需的参与。