Biology and Pathobiology of Kr??ppel-Like Factors (KLFs)

Kr??ppel 样因子 (KLF) 的生物学和病理学

• 批准号: 8004659
• 负责人: Vincent W Yang
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004659
• 关键词: Address; Award; Basic Science; Bioinformatics; Biology; Biophysics; Cardiology; Cardiovascular system; Cellular biology; Clinical Sciences; Collaborations; Development; Developmental Biology; Diabetes Mellitus; Differentiation and Growth; Digestive System Disorders; Discipline; Disease; Endocrinology; Erythroid; Family; Family member; Fostering; Functional disorder; Funding; Gastroenterology; Genetic; Goals; Hematology; Hepatology; Immune system; Inflammatory; International; Lead; Malignant Neoplasms; Molecular Biology; Obesity; Oral; Organ; Participant; Physiological; Physiological Processes; Physiology; Pluripotent Stem Cells; Process; Request for Applications; Research; Research Personnel; Role; Schedule; Signal Transduction; Somatic Cell; System; Therapeutic; Time; Travel; Zinc Fingers; abstracting; base; body system; design; embryonic stem cell; erythroid Kruppel-like factor; human disease; innovation; interest; meetings; member; oncology; planetary Atmosphere; pluripotency; posters; programs; public health relevance; respiratory; stem cell biology; symposium; therapeutic development; transcription factor

DESCRIPTION (provided by applicant): This application requests funding in partial support of a FASEB Summer Research Conference (SRC) entitled Biology and Pathobiology of Kruppel-Like Factors (KLFs). The 5-day conference is the first international meeting on this topic that will be held in the U. S. Kruppel-like factors are a family of zinc finger-containing transcription factors that represents a rapidly advancing field. Since the identification of the first member of this family, Erythroid Kr|ppel-Like Factor (EKLF or KLF1), some 16 years ago, an additional 21 members have been identified. Studies have indicated that KLFs exert important functions in diverse physiological processes involving the cardiovascular, digestive, respiratory, hematological and immune systems and in pathological states such as cancer, obesity, diabetes, and inflammatory conditions, among others. Recent studies have also implicated KLFs in the reprogramming of somatic cells to inducible pluripotent stem (iPS) cells and in maintaining the pluripotency of embryonic stem cells. The proposed symposium is designed to bring together a group of international leaders in the field of KLF research with the goal of stimulating discussion and fostering collaboration. The potential for therapeutic development in cardiovascular, cancer, diabetes, and inflammatory diseases based on KLF biology is a distinct possibility that may result from the meeting. The SPECIFIC OBJECTIVES of the meeting are: a. To provide a scientific program at the forefront of KLF research that is organized around the themes of physiological functions and organ-based pathophysiology of diseases. b. To provide a venue for meaningful interchanges among investigators in the KLF field with which to foster interactions and potential collaborations in both basic and clinical sciences. c. To provide a scientific platform with which to encourage active participation of young investigators and trainees. d. To provide an educational forum to participants. At the end of conference, we will generate a summary of the conference talks and envision that the conference will stimulate robust discussion and exciting new ideas with which to advance the field. We also anticipate to continue the conference platform and establish a biannual conference schedule on similar topics.

描述（由申请人提供）：本申请要求提供资金，以部分支持FaseB夏季研究会议（SRC），名为Kruppel样因素（KLFS）的生物学和病理学。为期5天的会议是该主题的第一次国际会议，该会议将在美国克鲁诗般的因素上举行，这是一个含锌指的转录因素的家族，代表了一个迅速前进的领域。自从大约16年前，自鉴定该家族的第一个成员（EKLF或KLF1）鉴定出红细胞KR | PPEL样因子（EKLF或KLF1），因此已经确定了21个成员。研究表明，KLFS在涉及心血管，消化，呼吸道，血液学和免疫系统的多种生理过程中发挥重要作用，以及在癌症，肥胖，糖尿病和炎症状况等病理状态等。最近的研究还暗示了KLF在体细胞重编程中，以诱导多能茎（IPS）细胞以及维持胚胎干细胞的多能性。拟议的研讨会旨在将KLF研究领域的一群国际领导人汇集在一起​​，以刺激讨论和促进协作。基于KLF生物学的心血管，癌症，糖尿病和炎症性疾病的治疗发展的潜力可能是会议可能导致的。 会议的具体目标是： 一个。在KLF研究的最前沿提供科学计划，该计划围绕生理功能的主题和基于器官的疾病病理生理。 b。为KLF领域的研究人员之间的有意义的互换提供了一个场所，以促进基础科学和临床科学的潜在协作。 c。提供一个科学平台，以鼓励年轻的研究人员和学员积极参与。 d。为参与者提供一个教育论坛。 在会议结束时，我们将摘要会议对话，并设想会议将刺激强大的讨论和激动人心的新想法，以推进该领域。我们还预计将继续会议平台，并建立对类似主题的双年度会议时间表。