Signaling and Therapeutics in Cell Death and Survival

细胞死亡和存活的信号传导和治疗

• 批准号: 8005302
• 负责人: ZAHRA ZAKERI
• 金额: $ 1.7万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005302
• 关键词: Address; Aging; Antiviral Agents; Apoptosis; Apoptotic; Area; Autophagocytosis; Cardiology; Cardiovascular Diseases; Cell Death; Cells; Chemicals; Chile; Collaborations; Commit; Country; Developed Countries; Developing Countries; Disease; Drug Industry; Educational workshop; Funding; Future; Home environment; Immunity; Immunology; International; Knowledge; Lead; Malignant Neoplasms; Mentors; Minority; Mitochondria; Necrosis; Neurodegenerative Disorders; Neurologic; Neurology; Pathway interactions; Plants; Published Comment; Request for Applications; Research; Research Personnel; Resort; Schedule; Science; Scientist; Senior Scientist; Signal Transduction; South America; South American; Students; Therapeutic; Time; Translational Research; Translations; Woman; Work; anticancer research; cancer cell; improved; insight; interest; meetings; public health relevance; rapid growth; research and development; symposium; trend

DESCRIPTION (provided by applicant): This application requests funds to support the International Conference on Cell Death, to be held at the hotel Marbella resort Maitencillo, Chile http://www.marbella.cl/ing/home.php, January 7-10, 2011. The title of the conference will be "Signaling and Therapeutics in Cell Death and Survival", but we will also include sessions addressing cell death in the most important diseases in developed countries. The meeting will focus on primary mechanisms of inducing and avoiding cell death (apoptosis, autophagy, and necrosis). Most of the speakers, including many of the most prominent theoreticians of cancer research will address the topic from the viewpoint of understanding malignancy. This meeting traditionally has been held in various countries to encourage more scientific exchanges than are possible in the US; the meetings have been well received by both participating US scientists and local scientists and students. We chose Chile to capture the rapid growth of science and pharmaceutical industries in South America and to encourage the translation of the mechanisms of cell death into therapies. Many unique species of South American plants potentially harbor antiviral and anticancer chemicals. Chile has embarked on a campaign to improve its intellectual and technical standing In comparison with other developing countries Chile spends proportionately more on R&D than other South American countries, including 30% women researchers but it is more economical and efficient for Western scientists to go to South America to interact with scientists in their home terrain. This meeting will encourage future collaborative work and exchanges in this research area. We will discuss the means by which the decision of a cell to die is modulated and triggered, how cells commit to autophagic, apoptotic or necrotic pathways and what decides the choice. These topics are of interest to aging, immunology, neurology, cardiology and specifically cancer. Our Women Mentoring Workshop has been very successful and popular with our attendees. Dr Eileen White will be the keynote speaker and will lead a panel discussion with an international cast. The full meeting will include sessions on alternative pathways to cell death; on cancer, immunity, aging and cell death; on neurological and cardiovascular diseases and cell death; mitochondria and cell death; and special talks of new forms of cell death. Talks by junior and senior scientists will be interspersed and will include a high percentage of women and minority speakers (41%) and chairs (67%). The schedule allows ample time for formal and informal discussions and socializing. An important aspect of our meetings has been a wrap-up talk, which summarizes the major new findings, traces emerging trends, and provides guidance for future trends. The wrap-up will be given by Mauro Piacentini, a prominent researcher in the area of cancer and cell death and who is exceptional at this task. PUBLIC HEALTH RELEVANCE: This meeting brings together experts from around the world to discuss the basic and translational science of cell death-apoptosis, autophagy, and other mechanisms-as it relates to cancer, aging, and neurodegenerative disease. In addition to the knowledge and insight gained, this meeting should stimulate exchanges and international collaboration, which themselves should widen the horizons for new discovery.

描述（由申请人提供）：本申请要求资金支持国际牢房死亡会议，将在智利Marbella Resort Maitencillo举行，智利http://www.marbella.cl/ing/home/home.php，1月7日2011年10月10日。会议的标题将是“细胞死亡和生存中的信号和治疗学”，但我们还将包括针对发达国家最重要疾病的细胞死亡的会议。会议将集中于诱导和避免细胞死亡的主要机制（凋亡，自噬和坏死）。包括许多最杰出的癌症研究理论家在内的大多数演讲者将从理解恶性肿瘤的角度解决该主题。传统上，在各个国家举行了这次会议，以鼓励比美国更多的科学交流。会议都受到参与的美国科学家，本地科学家和学生的好评。我们选择智利来捕捉南美科学和制药行业的快速增长，并鼓励将细胞死亡机理转化为疗法。南美植物的许多独特物种可能含有抗病毒和抗癌化学物质。智利与其他发展中国家相比，智利（Chile）的智力和技术地位比其他南美国家（包括30％的女性研究人员）更加经济和有效，而西方科学家去南方科学家更经济和有效美国与他们家中的科学家互动。这次会议将鼓励未来的合作工作和在该研究领域进行交流。我们将讨论细胞对死亡的决定的调制和触发的方法，细胞如何致力于自噬，凋亡或坏死途径，以及什么决定了选择。这些主题对衰老，免疫学，神经病学，心脏病学，尤其是癌症感兴趣。我们的妇女指导研讨会非常成功，并且在我们的与会者中受欢迎。艾琳·怀特（Eileen White）博士将成为主题演讲者，并将与国际演员一起进行小组讨论。完整的会议将包括有关细胞死亡替代途径的会议；关于癌症，免疫，衰老和细胞死亡；关于神经和心血管疾病以及细胞死亡；线粒体和细胞死亡；以及有关细胞死亡的新形式的特别谈判。初级和高级科学家的会谈将散布，并将包括很高比例的妇女和少数派演讲者（41％）和椅子（67％）。时间表为正式和非正式的讨论和社交活动提供了充足的时间。我们会议的一个重要方面是总结谈话，总结了主要的新发现，痕迹新兴趋势，并为未来的趋势提供指导。总结将由癌症和细胞死亡领域的著名研究人员毛罗·皮亚森蒂尼（Mauro Piacentini）进行，并且在这项任务方面表现出色。 公共卫生相关性：这次会议汇集了来自世界各地的专家，讨论细胞死亡 - 凋亡，自噬和其他机制的基本和转化科学 - 与癌症，衰老和神经退行性疾病有关。除了获得的知识和洞察力之外，这次会议还应刺激交流和国际合作，这本身应该扩大了新发现的视野。