Established Investigator Award in Pediatric Cancer Epidemiology

设立儿童癌症流行病学研究者奖

• 批准号: 8082325
• 负责人: Julie Ann Ross
• 金额: $ 13.96万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8082325
• 关键词: Address; Adult; Animal Model; Attention; Award; Biochemistry; Biological Markers; Birth Weight; Blood; Canada; Cancer Etiology; Cancer Research Network; Case-Control Studies; Cessation of life; Child; Childhood; Childhood Leukemia; Children' s Oncology Group; Collaborations; Collection; Complement; DNA; Data; Data Set; Development; Discipline; Disease; Dysmyelopoietic Syndromes; Educational process of instructing; Epidemiologic Studies; Epidemiologist; Epidemiology; Etiology; Faculty; Folate; Funding; Future; Gene Expression; Genes; Genetic; Grant; Hematopoietic Neoplasms; Incidence; Individual; Infant; Insulin-Like Growth Factor I; Knowledge; Malignant Childhood Neoplasm; Malignant Neoplasms; Measures; Mentors; Methods; Methylation; Modeling; Molecular; Molecular Epidemiology; Mothers; Mus; Neonatal Screening; Newborn Infant; Newly Diagnosed; Pathogenesis; Patients; Postdoctoral Fellow; Questionnaires; Registries; Reporting; Research; Research Activity; Research Personnel; Resources; Risk; Risk Assessment; Sampling; Senior Scientist Award; Specimen; Spottings; Students; Supplementation; Testing; Time; Training; Umbilical Cord Blood; United States; United States National Institutes of Health; Validation; Vitamins; Work; age group; aged; anticancer research; cancer epidemiology; career; cohort; design; epidemiology study; fetal; graduate student; in utero; innovation; interest; leukemia; next generation; novel; population based; programs; research study; tumor

DESCRIPTION (provided by applicant): Dr. Ross is internationally recognized for her work in pediatric cancer epidemiology. She has successfully developed several ancillary cross-disciplinary studies to augment epidemiological studies of childhood cancer. Further, as a natural progression of her research in childhood leukemia, she initiated two population-based molecular epidemiology studies of adult hematopoietic malignancies, anticipating that knowledge gained may be informative for all age groups. A K05 award will provide Dr. Ross protected research time (20% FTE) to pursue an innovative transdisciplinary approach toward understanding the etiology of childhood cancers. She plans to involve collaborators from other disciplines to address key questions. The overall outline of proposed research: 1) Application of murine models to augment etiological studies of childhood cancer; 2) Exploration of new initiatives utilizing biospecimens for potential future integration into childhood cancer studies; and 3) Expansion of analyses within existing research studies, including infant leukemia and other childhood malignancies, the Children's Oncology Group Childhood Cancer Research Network, and a new statewide study of myelodysplastic syndrome. Dr. Ross' proposed mentoring activities include enriching and expanding (20% FTE) her already wide-ranging mentoring of students (undergraduate, graduate, and post-doctoral) and junior faculty. She is program director of an NIH-funded training grant (T32) dedicated to training the next generation of pediatric cancer epidemiologists. In addition to serving on several master's and dissertation committees, Dr. Ross has served as primary research mentor to 15 graduate students, 8 postdocs, and 7 junior faculty. Her proposed mentoring pool during the K05 award period will include: 1) T32 trainees; 2) junior faculty developing careers in pediatric cancer research; and 3) at least three additional junior colleagues involved in K05-supported research activities. A K05 award will support both more concentrated and in-depth mentoring of future pediatric cancer researchers, as well as focus and stimulate new transdisciplinary research initiatives. PUBLIC HEALTH RELEVANCE: Dr. Ross is internationally known for her research that seeks to understand why some children get cancer. She also mentors several junior colleagues and trainees in pediatric cancer epidemiology. To find new breakthroughs, she proposes to intensify her efforts to explore childhood cancer using new data from animal models, newborn dried blood spots, as well as from her own existing studies. She will continue her mentoring activities, with special attention to teaching a transdisciplinary approach.

描述（由申请人提供）：罗斯博士因其在儿科癌症流行病学方面的工作而受到国际认可。她成功地开发了一些辅助跨学科研究，以增强儿童癌症的流行病学研究。此外，作为她在童年白血病研究的自然发展，她对成人造血恶性肿瘤的两项基于人群的分子流行病学研究开始，预计获得的知识可能对所有年龄段的人群提供信息。 K05奖将为Ross博士保护的研究时间（20％FTE）提供创新的跨学科方法，以理解儿童癌症的病因。她计划让来自其他学科的合作者解决关键问题。拟议研究的总体大纲：1）应用鼠模型在增强儿童癌症的病因研究中的应用； 2）探索利用生物测量的新倡议，将来将来将来将来融入儿童癌症研究； 3）在现有研究中扩展分析，包括婴儿白血病和其他儿童恶性肿瘤，儿童肿瘤学组儿童癌症研究网络以及一项全州跨全州骨髓增生综合症的研究。罗斯博士的拟议指导活动包括丰富和扩展（20％FTE）她已经广泛地指导学生（本科，研究生和博士后）和初级教师。她是NIH资助的培训补助金（T32）的计划总监，该培训补助金致力于培训下一代儿科癌症流行病学家。除了在几个硕士和论文委员会任职外，罗斯博士还担任了15名研究生，8名Postdocs和7名初级教师的主要研究导师。她在K05奖项期间提议的指导池将包括：1）T32受训者； 2）初级教师在儿科癌症研究中发展职业； 3）至少有三个参与K05支持的研究活动的初级同事。 K05奖将支持对未来儿科癌症研究人员的更多集中和深入的指导，并专注和刺激新的跨学科研究计划。 公共卫生相关性：罗斯博士以她的研究而闻名，该研究旨在了解某些孩子为什么患癌症。她还指导了几名初级同事和儿科癌症流行病学的学员。为了找到新的突破，她建议使用动物模型，新生的干血点以及她自己现有研究的新数据来加强自己为探索儿童癌症的努力。她将继续进行指导活动，并特别注意教授跨学科方法。