Multilevel Determinants of Breast Cancer: Translating Research into Interventions

乳腺癌的多层次决定因素：将研究转化为干预措施

基本信息

批准号：
8110858
负责人：
Parisa Tehranifar
金额：
$ 13.07万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8110858
关键词：
Address Adult African American Age Behavioral Biological Biological Factors Biological Markers Blood Glucose Body Weight decreased Breast Breast Cancer Prevention Breast Cancer Risk Factor Cancer Burden Cancer Control Cancer Prevention Intervention Censuses Central obesity Characteristics Clinical Collaborations Collection Communities Community Participation Community Surveys Computer Assisted Data Development Diet Disadvantaged Dyslipidemias Enrollment Environment Epidemiology Failure Female Focus Groups Funding Future Glucose Goals High Density Lipoprotein Cholesterol High Prevalence Hispanics Hypertension Individual Internet Intervention Intervention Studies Interview Investments K-Series Research Career Programs Knowledge Lead Link Mammary Gland Parenchyma Mammography Measures Mediating Medical Mentors Mentorship Metabolic Metabolic Diseases Metabolic syndrome Methods Minority Minority Groups Modeling National Cancer Institute Neighborhoods Nested Case-Control Study New York City Obesity Outcome Pathology Pathology Report Pathway interactions Physical activity Population Study Prevention Process Race Records Recruitment Activity Research Research Activity Research Personnel Research Training Resources Risk Risk Behaviors Risk Factors Risk Reduction Shapes Social Conditions Social Environment Social Interaction Social Network Social support Socioeconomic Status Statistical Methods Structure System Testing Time Tissues Training Translating Translational Research Triglycerides Woman anticancer research base blood lipid breast cancer diagnosis breast density cancer diagnosis cancer epidemiology cancer health disparity cancer prevention cancer risk cohort community setting contextual factors effective intervention experience follow-up low socioeconomic status malignant breast neoplasm member mortality population based pressure programs prospective public health relevance research and development skills social social integration social science research socioeconomics success therapy development

项目摘要

DESCRIPTION (provided by applicant): Eliminating cancer health disparities remains a high priority of the National Cancer Institute, and one of the most promising avenues for reducing the burden of cancer. Our nation's investment in cancer research has contributed to many breakthroughs in our knowledge of biomedical and behavioral risk factors. However, to effectively intervene on these risk factors, we must also understand the social contexts within which individual risks are developed and lead to persistent cancer health disparities. My goal in seeking this career development award is to become an independent researcher in the field of cancer health disparities, with a focus on multilevel research and intervention in racial/ethnic minority and socioeconomically disadvantaged communities. To leverage my existing training in social science research and cancer epidemiology, I propose additional training in applied intermediate marker and biomarker research, cancer prevention and control, community-engaged intervention research, and advanced statistical methods. An experienced interdisciplinary team of mentors will provide the necessary and complementary expertise and mentorship. My proposed research will examine the associations of social network characteristics (social integration, social support) and the metabolic syndrome (clustering of high blood glucose level, dyslipidemia, high blood pressure, abdominal obesity) with breast cancer risk and with mammographic breast density, a strong biomarker of breast cancer risk. I will investigate these aims in two separate study populations of Hispanic, African American, and White women, recruited from a socioeconomically disadvantaged community in New York City. I will build on extensive interview, clinical and biomarker data already available for these studies by obtaining the following data: neighborhood social environment (from U.S. Census data and previously constructed built environment data), breast density (measured from routine mammograms using validated computer-assisted methods) and breast cancer diagnosis (through review of medical and pathology records). Based on these results and in partnership with community representatives, I will conduct formative qualitative and quantitative research to guide the development of multilevel intervention strategies for breast cancer risk reduction. Together, these research activities will increase my understanding of the social environment characteristics, mediating behavioral factors, and biological pathways associated with breast cancer risk and increase my skills in community-engaged research and intervention development. Ultimately, this program of research will be applied to prevention of breast cancer risk through community-based interventions in low socioeconomic, racial/ethnic minority communities.

描述（由申请人提供）：消除癌症健康差异仍然是国家癌症研究所的高度优先事项，也是减轻癌症负担最有希望的途径之一。我们国家对癌症研究的投资促进了我们在生物医学和行为风险因素知识方面的许多突破。然而，为了有效干预这些风险因素，我们还必须了解个体风险产生并导致持续的癌症健康差异的社会背景。我寻求这一职业发展奖的目标是成为癌症健康差异领域的独立研究员，重点是对少数种族/族裔和社会经济弱势群体的多层次研究和干预。为了利用我在社会科学研究和癌症流行病学方面现有的培训，我建议在应用中间标记和生物标记研究、癌症预防和控制、社区参与干预研究和高级统计方法方面进行额外培训。经验丰富的跨学科导师团队将提供必要且互补的专业知识和指导。我提出的研究将探讨社交网络特征（社会融合、社会支持）和代谢综合征（高血糖水平、血脂异常、高血压、腹部肥胖）与乳腺癌风险和乳房 X 光检查乳腺密度之间的关系，乳腺癌风险的强生物标志物。我将在两个独立的研究人群中调查这些目标，其中包括西班牙裔、非裔美国人和白人女性，这些女性是从纽约市的一个社会经济弱势社区招募的。我将通过获取以下数据，以这些研究已有的广泛访谈、临床和生物标志物数据为基础：邻里社会环境（来自美国人口普查数据和之前构建的建筑环境数据）、乳腺密度（使用经过验证的计算机辅助从常规乳房 X 光检查中测量）方法）和乳腺癌诊断（通过检查医疗和病理记录）。根据这些结果，并与社区代表合作，我将进行形成性定性和定量研究，以指导制定降低乳腺癌风险的多层次干预策略。总之，这些研究活动将增加我对与乳腺癌风险相关的社会环境特征、中介行为因素和生物学途径的理解，并提高我在社区参与研究和干预开发方面的技能。最终，该研究计划将通过对社会经济水平较低、种族/族裔少数群体进行社区干预，应用于预防乳腺癌风险。