NCI X-ray free electron laser (XFEL) initiative

NCI X 射线自由电子激光 (XFEL) 倡议

• 批准号: 10014757
• 负责人: Yun Xing m wang
• 金额: $ 84.7万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10014757
• 关键词: Arrestins; Award; Biological; Crystallization; Data; Drug Targeting; Event; Future; G-Protein-Coupled Receptors; Granulovirus; Human; Image; Imagery; Lasers; Ligand Binding; Light; Manuscripts; Membrane Proteins; Molecular; Monitor; Organism; Paper; Peer Review; Phase Transition; Physiologic pulse; Process; Proteins; Publications; Reaction; Research Personnel; Resolution; Rhodopsin; Roentgen Rays; Science; Source; Structure; Synchrotrons; Temperature; The Sun; Time; Universities; Virion; Visual; crystallinity; molecular imaging; movie; nanocrystal; serial imaging; single molecule; x-ray free-electron laser

We have been mostly focusing on the analysis of the XFEL data that was collected in the past and made several fundamental discoveries. one of the most important results is the discovery of the mechanism of lattice phase transition triggered by ligand binding in a crystalline state. This mechanism is fundamental to the visualization of molecular movies. The results are being written in a manuscript. The XFEL beam at LCLS has been shut down for an upgrade for 2019 and will return to be operational in the middle of 2020.

我们主要关注对过去收集的 XFEL 数据的分析，并取得了一些基本发现。最重要的成果之一是发现了晶态配体结合引发的晶格相变机制。这种机制是分子电影可视化的基础。结果正在写成手稿。 LCLS 的 XFEL 光束已于 2019 年关闭进行升级，并将于 2020 年中期恢复运行。