Exposure to Mixtures of Emerging Contaminants in the Environment - Are Communities in Uganda at Health Risk?- A Case Study of Mbarara City.

接触环境中新兴污染物的混合物 - 乌干达的社区面临健康风险吗？ - 姆巴拉拉市的案例研究。

• 批准号: 10732272
• 负责人: Grace Birungi
• 金额: $ 10.81万
• 依托单位: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-27 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10732272
• 关键词: Adverse effects; Affect; Africa; African; Americas; Animals; Aromatic Polycyclic Hydrocarbons; Arsenic; Asia; Biological; Biological Markers; Biological Process; Cardiovascular Diseases; Case Study; Cessation of life; Chemicals; Chromatography; Chronic; Cities; Communities; Control Groups; Country; Data; Data Analyses; Developed Countries; Development; Development Plans; Diagnosis; Disease; Doctor of Philosophy; Ecosystem; Environment; Environmental Health; Europe; Exposure to; Fluorides; Goals; Grant; Health; Health Priorities; Heavy Metals; Histologic; Histopathology; Human; Human Resources; Industrialization; Intervention; Knowledge; Leadership; Link; Malignant Neoplasms; Mammals; Manuscripts; Mentors; Mentorship; Metabolic; Metabolism; Methods; Monitor; Morbidity - disease rate; Municipalities; Mus; National Institute of Environmental Health Sciences; Nitrates; Organ; Pathway interactions; Persons; Pesticides; Plants; Pollution; Prognosis; Public Health; Publications; Recommendation; Reporting; Research; Research Methodology; Research Personnel; Risk; Risk Assessment; Risk Estimate; Science; Secure; Serum; Source; Statistical Data Interpretation; Structure; Surface; System; Techniques; Technology; Testing; Training; Uganda; Universities; Water; Water Stress; Work; Writing; albino mouse; anthropogenesis; biomarker validation; candidate identification; career; career development; disorder prevention; disorder risk; drinking water; environmental toxicology; ground water; high risk; insight; low and middle-income countries; metabolic profile; metabolome; metabolomics; mortality risk; pollutant; prevent; responsible research conduct; skills; wastewater epidemiology

Project Summary/Abstract: River Rwizi the main source of water for Mbarara City and surroundings is threatened by anthropogenic pollution. Preliminary studies detected pesticides, polycyclic aromatic hydrocarbons and heavy metals at concentrations higher than WHO drinking water recommendations, exposing over 91,964 City residents to pollutants. Pollutant exposure is linked to Non-Communicable Diseases (NCDS) and emerging pollutants (EPs) pose new threats to human health. No study has fully characterized EPs in River Rwizi or wastewater treatment plants (WWTPs) in its catchment yet EPs and wastewater have an inextricable link. It is hypothesized that the changing anthropogenic activities in Mbarara City have increased the concentrations of EPs in River Rwizi, exposing residents to higher risks of NCDs through perturbations of the metabolome. This study will inform intervention strategies to reduce environmentally induced diseases in LMICs contributing to NIEHS goals and Uganda’s health priorities of disease prevention, mitigation and control. Candidate: I have skills in research methodology, data analysis, scientific presentation, and manuscript writing accrued during my BS, MSc and PhD training and research works that resulted in 23 publications so far. This K43 grant will secure me training and mentorship in: advanced research methodology, management of large data, research administration, responsible conduct of research, and grant writing. This proposed career development plan will build on my previous training to facilitate me to become an independent investigator through five training goals: 1) execution of advanced qualitative and quantitative 1H-NMR and LC-MS metabolomics; 2) advanced statistical analyses; 3) interpretation of metabolomics data in the context of biological processes; 4) strengthening leadership and professional skills; and 5) application of histopathology to chronic exposure studies. Mentors and Environment: This plan will benefit from physical and human resources available through Mbarara University of Science and Technology [through Dr. Tusubira and Prof. Alele (Biochemist and Toxicologist)], the Universities of San Diego and Makerere [Profs. Bolender and Ntale, Chemists]. Research: I will (i) Identify and quantify EPs in River Rwizi and in WWTPs in its catchment using chromatographic techniques and Wastewater Epidemiology approach. (ii) The effect of exposure to EPs will be studied by metabolomics and histopathology approaches. My short-term goal is to identify candidate metabolites associated with exposure to EPs while my long term goal is to develop a career in Environmental toxicology. Towards the end of this support I will apply for an R01.

项目摘要/摘要：鲁维兹河是姆巴拉拉市和姆巴拉拉市的主要水源 初步研究发现，环境受到人为污染的威胁。 多环芳烃和重金属的浓度高于世界卫生组织饮用的浓度 用水建议，使超过 91,964 名城市居民暴露在污染物之下。 与非传染性疾病 (NCDS) 和新兴污染物 (EP) 相关 尚无研究全面描述鲁维济河或废水中的 EPs 所面临的威胁。 污水处理厂（WWTP）位于其流域内，但环保局和废水有着密不可分的联系。 据了解，姆巴拉拉市不断变化的人类活动增加了 鲁维济河中的 EP 浓度较高，使居民面临更高的非传染性疾病风险 这项研究将为减少代谢组的干扰提供干预策略。 中低收入国家环境诱发的疾病有助于 NIEHS 目标和乌干达的健康 疾病预防、缓解和控制的优先事项：我有研究技能。 我在我期间积累的方法论、数据分析、科学演示和手稿写作 学士、硕士和博士的培训和研究工作迄今已发表 23 篇出版物。 赠款将为我提供以下方面的培训和指导：高级研究方法、管理 大数据、研究管理、负责任的研究行为和资助写作。 拟议的职业发展计划将以我之前的培训为基础，以帮助我 通过五个培训目标成为一名独立调查员：1）执行高级任务 定性和定量 1H-NMR 和 LC-MS 代谢组学 2) 高级统计； 分析；3) 生物过程中的代谢组学数据的解释；4) 加强领导力和专业技能；5）组织病理学在慢性病中的应用 接触研究和环境：该计划将受益于身体和人类。 姆巴拉拉科技大学提供的资源[通过 Dr. Tusubira 和 Alele 教授（生物化学家和毒理学家）]，圣地亚哥大学和 Makerere [Bolender 和 Ntale 教授，化学家]：我将 (i) 识别和量化 EP。 鲁维济河及其流域污水处理厂使用色谱技术和废水 (ii) 将通过代谢组学和方法研究接触 EP 的影响。 我的短期目标是确定相关的候选代谢物。 接触 EP，而我的长期目标是在环境领域发展职业生涯 在本次支持结束时，我将申请 R01。