Pilot Projects and Trans-Network Activities

试点项目和跨网络活动

基本信息

批准号：
10733397
负责人：
Moon Shao-Chuang Chen
金额：
$ 0.34万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733397
关键词：
Achievement Administrator Affect African American Asian Americans Basic Cancer Research California Cancer Model Cancer Patient Cells Collaborations Collection Comprehensive Cancer Center Conduct Clinical Trials Data Commons Decision Making Development Discipline Disparity Doctor of Philosophy Drug Combinations Ensure Evaluation Fostering Funding Goals Grant Health Disparities Research Human Resources International Latino Latino Population Lead Los Angeles Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Methods Minority Groups Monitor Moon Native Hawaiian Pacific Islander Pathology Pharmaceutical Preparations Phase Pilot Projects Preclinical Testing Procedures Reproducibility Research Research Personnel San Francisco Site Stomach Neoplasms System Technology Testing Texas Universities Validation Woman Xenograft procedure cancer health disparity chemotherapy community engagement design drug testing efficacy validation ethnic minority ethnic minority population experience innovative technologies malignant stomach neoplasm meetings minority patient novel novel therapeutics patient derived xenograft model people of color pre-clinical precision oncology preclinical study programs racial minority racial minority population repository symposium targeted treatment treatment response tumor

项目摘要

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Reduce Cancer Health Disparities PROJECT SUMMARY/ABSTRACT The goal of the Pilot Projects and Trans-Network Activities Core (PPTNAC) is to contribute to the achievement of the University of Californiaand UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) overall objectives of developing PDX trial strategies for preclinical testing of single agents and drug combinations. This D-PDTC focuses on the predominant racial/ethnic minority populations residing in California and Texas, namely, Latinos, African American [AAs] and Asian American/Native Hawaiian/Pacific Islander [AANHPIs]. The focus will be on gastric cancer which disproportionately affect Latinos and all populations of color, and lung cancer, which has a high burden in Latino and AANHPI women. Key personnel for this Core include the PPTNAC Lead Moon S. Chen, Jr., who has successfully led PPTNAC in our ongoing UCaMP PDX Development and Trial Center (PDTC), all Site PIs, Contact PI and Administrative Core Lead Luis Carvajal-Carmona, and UCaTS Grant Administrator. As such, PPTNAC investigators reflect multiple relevant disciplines that foster the evaluation of pilot studies and trans-network activities including cancer health disparities, pre-clinical studies, pathology, and basic cancer research. PPTNAC will also facilitate the interaction of UCaTS with NCI, PDXNet Data Commons and Coordinating Centers (PDCCC), other PDTCs, and non- PDXNet investigators through funded projects. Specifically, the PPTNAC Aims are to: (1) Facilitate Internal Pilot Projects; (2) Facilitate Cross-PDXNet Activities (Pilot Studies Development and Evaluation); and (3) Engage Non-Network Investigators; and (4) Share Innovative Technologies using PDXs (Collaboration with non-PDXNet investigators).

试点项目和跨网络活动核心加州大学和德克萨斯大学西南分校多样性患者来源的异种移植物 (PDX) 开发减少癌症健康差异的试验中心 (UCaTS) 项目概要/摘要试点项目和跨网络活动核心 (PPTNAC) 的目标是为实现这一目标做出贡献加州大学和德克萨斯大学西南分校多样性患者来源的异种移植物 (PDX) 开发和试验中心 (UCaTS) 开发用于单药临床前测试的 PDX 试验策略的总体目标和药物组合。该 D-PDTC 重点关注居住在以下地区的主要种族/族裔人口：加利福尼亚州和德克萨斯州，即拉丁裔、非裔美国人 [AA] 和亚裔美国人/夏威夷原住民/太平洋人岛民[AANHPI]。重点是胃癌，它对拉丁裔和所有人群的影响不成比例。有色人种和肺癌，这对拉丁裔和 AANHPI 女性来说是一个沉重的负担。关键人员该核心成员包括 PPTNAC 负责人 Moon S. Chen, Jr.，他在我们正在进行的项目中成功领导了 PPTNAC UCaMP PDX 开发和试验中心 (PDTC)、所有站点 PI、联系人 PI 和行政核心负责人 Luis 卡瓦哈尔-卡莫纳 (Carvajal-Carmona) 和 UCaTS 拨款管理员。因此，PPTNAC 调查人员反映了多个相关的促进试点研究和跨网络活动（包括癌症健康）评估的学科差异、临床前研究、病理学和基础癌症研究。 PPTNAC也将促进互动 UCaTS 与 NCI、PDXNet 数据共享和协调中心 (PDCCC)、其他 PDTC 和非 PDXNet 调查人员通过资助的项目。具体而言，PPTNAC 的目标是： (1) 促进内部试点项目； (2) 促进跨 PDXNet 活动（试点研究开发和评估）； (3) 参与非网络调查员； (4) 使用 PDX 分享创新技术（与非 PDXNet 合作）调查员）。