Molecular Physiology Core Applied to Acute Lung Injury

分子生理学核心应用于急性肺损伤

基本信息

批准号：
7936177
负责人：
MARK W GERACI
金额：
$ 51.4万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7936177
关键词：
Acute Lung Injury Address Adult Respiratory Distress Syndrome Alveolar Anesthesiology Animal Model Animals Apoptosis Area Arts Asthma Biological Models Biometry Capillary Endothelial Cell Cardiology Cardiovascular system Cell Culture Techniques Childhood Chronic Obstructive Airway Disease Clinical Clinical Data Clinical Research Clinical Trials Colorado Comprehensive Cancer Center Confocal Microscopy Core Facility Critical Care Development Elements Faculty Fibrosis Focus Groups Funding Genetic Genomics Grant Health Healthcare Histology Hospitals Hypertension Image Image Analysis Immunity Inflammation Injury Institution Interstitial Lung Diseases Investigation Joints Laboratories Lead Liver diseases Lung Lung Transplantation Lung diseases Malignant neoplasm of lung Medicine Mentorship Methodology Mission Molecular Molecular Biology National Heart, Lung, and Blood Institute Occupational Medicine Outcome Oxidative Stress Participant Pathologist Pathology Patients Pediatrics Physiological Physiology Process Productivity Program Research Project Grants Pulmonary Circulation Pulmonary Fibrosis Pulmonary Hypertension Pulmonology Recruitment Activity Research Research Infrastructure Research Personnel Research Training Resources Sampling Sarcoidosis Science Smoking Stem cells Structure Structure of parenchyma of lung System Training Translational Research Translations Universities Ventilator base career development cigarette smoke-induced clinical epidemiology digital imaging follower of religion Jewish gastrointestinal image processing interdisciplinary approach interest lung injury medical schools member morphometry programs ranpirnase repaired square foot tool

项目摘要

DESCRIPTION (provided by applicant): This P30 application seeks to provide resources to recruit Dr. Eric Schmidt to lead the Molecular Physiology and Imaging Core (MPIC) in the Division of Pulmonary Sciences and Critical Care Medicine. The Division is based at the University of CO Denver and encompasses the University's affiliate faculty (at National Jewish Health, Denver Health and Hospital System, and the Denver VA Hospital). The research expertise encompasses acute lung injury (ALI), pulmonary hypertension, lung cancer, COPD, occupational medicine, interstitial lung diseases and asthma, among others. The Division is an integral participant of the NIH-funded CO Clinical and Translational Sciences, University of CO Comprehensive Cancer Center, and Program Project Grant in the Cardiovascular Pulmonary Research (CVP) Lab. The Division has membership in every NHLBI Lung Division Clinical Network, including the ARDSnet, COPDnet, IPFnet, and the Asthma Clinical Research Network (ACRN). The Division has gathered substantial institutional resources to implement the Program in Translational Lung Research, which will support the MPIC. The MPIC will be built with a focus on ALI, in its protean manifestations. This emphasis is based on the overall relevance of ALI and the breadth of pathogenetic mechanisms, which ultimately are part of several lung disease processes. The expertise of the MPIC will also extend to studies in pulmonary hypertension, interstitial lung disease, and cigarette smoke induced lung injury. The choice to recruit Dr. Schmidt to establish this Core was based on a selective process of recruitment, professional development, career support, and long-term retention plans. With the direct support of the PI, Dr. Mark Geraci, and Drs. Ivor Douglas and Rubin Tuder, Dr. Schmidt will coordinate the interaction across affiliated programs & the Division & Departments within the medical school (Medicine, Anesthesiology and Pediatrics), the Colorado CTSI, and programmatic initiatives involving the CVP, and the imaging core at the Department of Medicine. A research committee, which will include several established NIH-funded investigators in lung diseases, will assist Dr. Schmidt with the administration of the Core. A plan to assess the Core, scientific productivity, and Dr. Schmidt's career development & mentorship are in place. This proposal targets the integrated physiological and imaging study of acute lung injury, which compromises 190,000 patients per year. The proposed MPIC provides a central experimental element for the successful translation from/to clinical data and relevant model systems, as it synergizes with a range of other methodologies, which in isolation cannot address the complexity of pulmonary diseases, including acute lung injury.

描述（由申请人提供）：该P30申请旨在提供资源来招募Eric Schmidt博士，以领导肺科学和重症监护医学分区的分子生理和成像核心（MPIC）。该部门位于丹佛市公司，涵盖该大学的会员教师（在国家犹太人健康，丹佛健康和医院系统以及丹佛VA医院）。研究专业知识包括急性肺损伤（ALI），肺高血压，肺癌，COPD，职业医学，间质肺部疾病和哮喘等。该部门是NIH资助的CO临床和转化科学，CO综合癌症中心和心血管肺部研究（CVP）实验室中计划项目赠款的组成部分。该部门具有每个NHLBI肺部临床网络的成员资格，包括Ardsnet，Copdnet，Ipfnet和哮喘临床研究网络（ACRN）。该部门已收集了大量的机构资源，以在转化肺部研究中实施该计划，该计划将支持MPIC。 MPIC将以其蛋白质表现为重点。这种重点是基于Ali的整体相关性和致病机制的广度，最终是几种肺部疾病过程的一部分。 MPIC的专业知识还将扩展到肺高血压，间质性肺病和香烟烟雾诱发肺损伤的研究。招募施密特博士建立此核心的选择是基于选择性的招聘，专业发展，职业支持和长期保留计划的选择。在PI的直接支持下，Mark Geraci博士和Drs。施密特博士的艾弗·道格拉斯（Ivor Douglas）和鲁宾·厄（Rubin Tuder）将协调医学院附属计划以及分部与部门的相互作用（医学，麻醉学和儿科），科罗拉多州CTSI以及涉及CVP的程序化计划，以及医学院的成像核心。一个研究委员会将包括几名已建立的NIH资助的肺部疾病研究人员，将协助施密特博士进行核心管理。评估核心，科学生产力和施密特博士的职业发展与指导计划的计划已经到位。该建议针对急性肺损伤的综合生理和成像研究，每年损害190,000名患者。提出的MPIC为从/到临床数据和相关模型系统的成功翻译提供了一个中心实验元素，因为它与一系列其他方法协同作用，这些方法无法隔离地解决包括急性肺损伤在内的肺部疾病的复杂性。