Developing an in vivo infectious disease training program at the University of Cape Town

开普敦大学开发体内传染病培训项目

• 批准号: 10731772
• 负责人: William Horsnell
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF CAPE TOWN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-20 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731772
• 关键词: Acceleration; Africa South of the Sahara; Animal Model; Antimicrobial Resistance; Bacterial Infections; Biology; California; Clinical Research; Communicable Diseases; Complement; Development; Disease; Disease model; Ethics; Exclusion; Grant; Home; Human; Immunity; Infection; Infectious Diseases Research; International; Klebsiella pneumoniae; Mus; Mycobacterium tuberculosis; Pathogenesis; Primates; Process; Public Health; Reagent; Research; Research Personnel; Research Training; Resources; Salmonella enterica; South Africa; Streptococcus pneumoniae; Training; Training Programs; Universities; Vaccines; Veterinary Schools; Virulence; Work; animal facility; biological research; in vivo; infectious disease model; mortality; pathogen; pathogenic bacteria; pre-doctoral; prevent; programs; symposium

PROJECT SUMMARY This application seeks to plan and develop a research training program at the University of Cape town (UCT) that will focus on understanding basic mechanisms underlying bacterial disease in sub-Saharan Africa (SSA). Bacterial infectious diseases (excluding mTB) are a huge public health problem in SSA as infections caused by bacterial pathogens, such as Salmonella enterica and Streptococcus pneumonia, are major causes of mortality. The impact of these pathogens is compounded by widespread antimicrobial resistance (AMR), vaccines against these pathogens developed outside of SSA being less effective at preventing serious illness and increasing pathogen virulence. Combined these limit treatment options of these recognized pathogens and promote emergence of new bacterial causes of mortality (e.g. Klebsiella pneumonia). While microbiological and clinical research groups in South Africa contribute significantly to global understanding of these diseases, these groups do not significantly complement this work with complementary mechanistic in vivo studies. Thus, an urgent need exists to develop advanced regional training in undertaking such in vivo research into bacterial pathogenesis and host immunity. The objective of our proposed training program is to fill this gap by leveraging existing strengths and unique resources both at UCT and at our overseas partners at the University of California Davis (UCD) to develop a research training program. UCT is home to a world class animal facility that is underutilized by researchers studying non-mTB bacterial infections. UCD has unique resources that support animal modelling including the #1 ranked Veterinary School globally, the California National Primate Research Center, the internationally renowned Mouse Biology Program, and a T32 supported predoctoral program focussed on Animal models of Infectious Diseases. Thus unique expertise exists at UCD that will be invaluable in supporting the UCT program. We propose a 2-year planning process that will develop an advanced training platform in in vivo studies of non-mTB bacterial infection in SSA which we will submit as a competitive proposal for a D43 Global Infectious Disease Research Training program. Project leaders at UCT and UCD have already identified existing overlapping research strengths that will benefit from in vivo disease modelling at UCT. D71 supported symposia and researcher exchanges between UCT and UCD will support the key interactions enabling realization of a competitive and deliverable D43 program. The planning of this program will also require implementation of ethically approved SOPs, acquisition of permits to allow transfer of state-of-the-art research reagents to UCT, as well as development of a new research training program for junior investigators and fellows. The final submission of a competitive D43 program grant will present a program that will enable high impact mechanistic bacterial infection biology studies at UCT. The research that emanates from this will accelerate regional and global control of devastating human bacterial infectious diseases.

项目概要 该申请旨在规划和开发开普敦大学 (UCT) 的研究培训项目 重点是了解撒哈拉以南非洲（SSA）细菌性疾病的基本机制。 细菌传染病（不包括转移性结核病）是撒哈拉以南非洲地区一个巨大的公共卫生问题，因为感染引起的 细菌病原体，如肠沙门氏菌和肺炎链球菌，是导致 死亡。广泛的抗菌素耐药性 (AMR) 加剧了这些病原体的影响， 在 SSA 之外开发的针对这些病原体的疫苗在预防严重疾病方面效果较差 并增加病原体的毒力。结合这些限制了这些公认病原体的治疗选择 并促进新的细菌性死亡原因的出现（例如肺炎克雷伯菌）。尽管 南非的微生物和临床研究小组为全球理解做出了重大贡献 在这些疾病中，这些群体并没有通过补充机制来显着补充这项工作 体内研究。因此，迫切需要开展先进的区域培训来开展此类体内培训。 研究细菌发病机制和宿主免疫。我们提议的培训计划的目标是 利用 UCT 和海外合作伙伴的现有优势和独特资源来填补这一空白 在加州大学戴维斯分校 (UCD) 开发研究培训计划。 UCT 是一个世界的家园 研究非结核分枝杆菌细菌感染的研究人员未充分利用此类动物设施。都柏林大学有 支持动物建模的独特资源，包括全球排名第一的兽医学校、 加州国家灵长类动物研究中心、国际知名的小鼠生物学项目以及 T32 支持专注于传染病动物模型的博士前项目。因而独一无二 UCD 拥有的专业知识对于支持 UCT 项目非常宝贵。我们提出2年规划 该过程将开发一个先进的培训平台，用于非结核分枝杆菌细菌感染的体内研究 我们将作为 D43 全球传染病研究培训的竞争性提案提交 SSA 程序。 UCT 和 UCD 的项目负责人已经确定了现有的重叠研究优势 这将受益于 UCT 的体内疾病建模。 D71支持研讨会和研究人员交流 UCT 和 UCD 之间将支持关键的互动，从而实现具有竞争力和可交付成果 D43 程序。该计划的规划还需要实施经道德批准的标准操作程序， 获得许可证以允许将最先进的研究试剂转移到 UCT 以及开发 针对初级研究人员和研究员的新研究培训计划。最终提交竞争性的 D43 计划拨款将提出一项能够实现高影响机制细菌感染生物学的计划 在UCT学习。由此产生的研究将加速区域和全球的控制 毁灭性的人类细菌传染病。