Enhancement of RNA Related Research at Case Western Reserve University

凯斯西储大学 RNA 相关研究的加强

• 批准号: 7944122
• 负责人: TIMOTHY W. NILSEN
• 金额: $ 39.25万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944122
• 关键词: Enhancement; RNA; Related; Research; Case; Enhancement; RNA; Related; Research; Case

DESCRIPTION (provided by applicant): The objective of this proposal is to recruit two tenure track Assistant Professor RNA biologists, one who specializes in bioinformatics and one who specializes in genomic approaches to the study of non-coding RNAs, to join and complement the faculty of the Center for RNA Molecular Biology at Case Western Reserve University School of Medicine. We believe that our current faculty are very strong in the areas of molecular biology and biochemistry. It is equally clear that we lack expertise in these two important and exciting areas. Regarding the first area, while we have access to two Solexa genome analyzers, we must seek outside collaborators to interpret the data. We desperately need a talented informatician who can maintain his/her own interests and also serve as an in house expert. We strongly believe that if we can recruit the appropriate individual, we will make a quantum leap forward in our research capability. Regarding the second area, it is abundantly clear that the next frontier in RNA research will be the analysis of the functions of non-coding RNAs- both small (e.g. mlRNAs, piRNAs) and large (e.g. Xist). We view large non-coding RNAs to be particularly interesting as the small RNA field is now heavily populated. We feel that if we can recruit the appropriate investigator, he/she will become a leader in the field of large non-coding RNAs and benefit greatly from the Center's expertise in molecular and biochemical approaches. Moreover, assuming the recruit takes a genome wide approach to this question he/she will undoubtedly synergize with the informatics recruit. The Dean of the Medical School has been highly supportive of RNA research at Case Western Reserve and has committed resources to support any recruited faculty for at least two years beyond the duration of this award if granted. In addition, she and the Director of Comprehensive Cancer Center have committed in excess of $500,000 for establishment of an RNA Core facility. We anticipate that the proposed two new investigators will immediately enhance our ability to conduct multidisciplinary research projects.

描述（由申请人提供）：该提案的目的是招募两名终身助理教授RNA生物学家，一位专门从事生物信息学的人，一位专门研究非编码RNA的基因组方法，以加入和补充医学案例西部储备大学的RNA分子生物学中心。我们认为，我们目前的教师在分子生物学和生物化学领域非常强大。同样清楚的是，我们在这两个重要而令人兴奋的领域缺乏专业知识。关于第一个领域，尽管我们可以访问两个Solexa基因组分析仪，但我们必须寻求外部合作者来解释数据。我们迫切需要一位才华横溢的知情人士，他们可以维持自己的利益并担任众议院专家。我们坚信，如果我们能招募适当的个人，我们将在我们的研究能力中向前迈进。关于第二个区域，很明显，RNA研究的下一个前沿将是对非编码RNAS-小（例如MLRNA，PIRNA）和大型（例如Xist）的功能的分析。我们认为大型非编码RNA特别有趣，因为现在人口稠密的小RNA场。我们认为，如果我们可以招募适当的调查员，他/她将成为大型非编码RNA领域的领导者，并从该中心在分子和生化方法方面的专业知识中受益匪浅。此外，假设新兵对这个问题采取了一种基因组的方法，他/她无疑将与Informatics Recruit协同作用。医学院的院长在Case Western Reserve上高度支持RNA研究，并承诺资源以支持任何被招募的教师至少两年以后的奖项，如果获得授予。此外，她和综合癌症中心主任已承诺建立RNA核心设施超过500,000美元。我们预计拟议的两名新研究人员将立即增强我们进行多学科研究项目的能力。