Emotional dysfunction and childhood behavioral disturbance

情绪功能障碍和儿童行为障碍

• 批准号: 7594588
• 负责人: James Blair
• 金额: $ 117.89万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594588
• 关键词: Amygdaloid structure; Anterior; Anxiety; Attention deficit hyperactivity disorder; Behavioral; Child; Childhood; Conduct Disorder; Disease; Emotional; Empathy; Functional disorder; Goals; Hyperactive behavior; Impairment; Link; Neurocognitive; Performance; Prefrontal Cortex; Process; Protocols documentation; Punishment; Research; Rewards; Stimulus; System; Testing; callous unemotional trait; neuroimaging; relating to nervous system; response; trait

The goal of this protocol is to investigate the neurocognitive underpinnings of the emotional dysfunction linked to childhood behavioral disturbance; in particular, extreme conduct disorder but also attention deficit and hyperactivity disorder (ADHD). The functional hypotheses that we are testing with both neurocognitive and neuroimaging paradigms are that: (1) extreme conduct disorder, but not ADHD, is associated with dysfunction in the formation and operational use of, stimulus-punishment and to a lesser extent stimulus-reward association information; and (2) that ADHD, but not extreme conduct disorder, is associated with impairment in executive systems related to the representation and execution of task demands. At the anatomical level, we anticipate reduced activation of emotional related systems in children with extreme conduct disorder during response selection and emotional impact tasks (in particular, reduced activation of the amygdala, regions of orbitofrontal cortex and anterior cingulate). We anticipate that the neural response of children with ADHD during these tasks will be less anomalous. We anticipate that the neural response of children with ADHD during the performance of response control tasks to be anomalous (with considerable greater recruitment of anterior and posterior compensatory systems).

该协议的目标是调查与儿童行为障碍相关的情绪功能障碍的神经认知基础；特别是极端行为障碍，还有注意力缺陷和多动障碍（ADHD）。 我们正在用神经认知和神经影像范式测试的功能假设是：（1）极端品行障碍（但不是 ADHD）与刺激-惩罚以及较小程度上的刺激-奖励的形成和操作使用功能障碍相关。协会信息； (2) ADHD（而非极端行为障碍）与执行系统的损伤有关，而执行系统与任务要求的表达和执行有关。 在解剖学层面上，我们预计患有极端行为障碍的儿童在反应选择和情绪影响任务期间情绪相关系统的激活会减少（特别是杏仁核、眶额皮层和前扣带皮层区域的激活减少）。 我们预计患有多动症的儿童在执行这些任务时的神经反应将不会那么异常。 我们预计，患有多动症的儿童在执行反应控制任务期间的神经反应是异常的（前代偿系统和后代偿系统的募集量相当大）。