Mechanisms controlling the expression of a rhythmic behavior

控制节律行为表达的机制

• 批准号: 8002391
• 负责人: Olivia J Mullins
• 金额: $ 2.84万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8002391
• 关键词: Accounting; Area; Behavior; Behavioral; Brain; Breathing; Cells; Code; Complex; Computer Simulation; Data; Electrodes; Electrophysiology (science); Foundations; Ganglia; Knowledge; Learning; Leeches; Locomotion; Maintenance; Memory; Modeling; Myxoid cyst; Nervous system structure; Neurons; Production; Property; Prosthesis; Public Health; Publishing; Research; Spinal Cord; Swimming; System; Testing; Work; base; design; injured; novel; programs; public health relevance; therapy design

DESCRIPTION (provided by applicant): Rhythmic behavior production is essential for activities such as locomotion and breathing. A disruption to these systems can cause difficulties in executing even simple tasks. For this reason, extensive research has focused on the mechanisms behind rhythmic behaviors. Areas such as behavior-initiation and oscillation production are well understood in several species. However, there is a paucity of information regarding control of rhythmic behavior duration. How are nervous systems able to maintain the high level of excitation necessary to generate a sustained behavior? This proposal examines the maintenance of rhythmic swimming in the medicinal leech by testing the novel Swim-Maintenance Model. This model, based on preliminary and published data, proposes that multiple levels of control work in concert to sustain swimming. A novel cell, "OM", has been identified in a caudal midbody ganglion whose sustained excitation prolongs swimming indefinitely. In the caudal brain, several cells have been identified whose inhibition appears to be necessary for prolonged swimming, and whose excitation contributes to swim-termination. Sharp-electrode electrophysiology will be employed to classify the functional, cellular and circuit properties of these novel swim-control neurons. Our detailed knowledge of the cell-to-cell connections in leech swim-networks makes it an excellent system for computer modeling. Experimentally obtained data will be entered into the Neurodynamix II program to test if the Swim- Maintenance Model can, indeed, account for swim-maintenance. Completion of the proposed research will increase our understanding of how nervous systems sustain rhythmic behavior, forming a foundation for research on behavior maintenance in more complex species. Additionally, this proposal will fill an important gap in an otherwise well-characterized leech swim-system that can be used to study other areas such as spike coding, learning and memory, behavioral choice and in designing neuro-prosthetic devices. PUBLIC HEALTH RELEVANCE: Completion of this proposal will elucidate mechanisms that sustain rhythmic behavior, an area that is poorly understood. This information can be applied in designing therapies to treat injured rhythmic systems such as the spinal cord.

描述（由申请人提供）：节奏行为的产生对于诸如运动和呼吸等活动至关重要。这些系统的中断可能会在执行简单任务时造成困难。因此，广泛的研究集中在节奏行为背后的机制上。在几种物种中，对行为引入和振荡产生等领域有充分的​​了解。但是，关于控制节奏行为持续时间的信息很少。神经系统如何能够维持产生持续行为所需的高水平的激发？该提案通过测试新型游泳维护模型来研究药物中的节奏游泳。该模型基于初步和已发布的数据，提出了多个级别的控制工作，以维持游泳。在尾部中间神经节中已经确定了一个新颖的细胞“ OM”，其持续的激发无限期地延长了游泳。在尾骨中，已经鉴定出了几个细胞，它们的抑制作用似乎是长时间游泳所必需的，其激发会导致游泳终止。将采用尖锐电极电生理学来对这些新型游泳神经元的功能，细胞和电路特性进行分类。我们对水ech游泳网络中细胞对电池连接的详细了解使其成为计算机建模的绝佳系统。实验获得的数据将输入到Neurodynamix II计划中，以测试游泳维护模型是否确实可以说明游泳维护。拟议研究的完成将增加我们对神经系统如何维持节奏行为的理解，为更复杂物种的行为维持研究构成基础。此外，该提案将填补原本良好的水ech游泳系统中的重要差距，该差距可用于研究其他领域，例如尖峰编码，学习和记忆，行为选择以及设计神经原理设备。 公共卫生相关性：该提案的完成将阐明维持节奏行为的机制，该领域的理解不足。这些信息可以应用于设计疗法以治疗受伤的节奏系统（例如脊髓）。