Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL)

塞拉利昂新发病​​毒感染研究伙伴关系 (PREVSL)

• 批准号: 10375501
• 负责人: DONALD SAMUEL GRANT
• 金额: $ 19.32万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-22 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375501
• 关键词: Address; African; Allied Health Sciences; Clinical Management; Clinical Trials; Collaborations; Conduct Clinical Trials; Country; Disease Outbreaks; Ebola; Epidemic; Ethics; Future; Government; Grant; Guinea; Health Professional; Health Services; Health system; Hospitals; Infectious Diseases Research; Infrastructure; Investments; Knowledge; Lassa Fever; Liberia; Medicine; Mentors; Methodology; Patients; Public Health; Recording of previous events; Research; Research Project Grants; Research Training; Sierra Leone; System; Training; Training Programs; Universities; Vaccine Clinical Trial; Viral Hemorrhagic Fevers; Virus; Virus Diseases; clinical investigation; college; health science research; implementation science; improved; innovation; medical schools; response; skills; transmission process

Project Summary/ Abstract: The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have just completed a Planning Grant for Emerging Epidemic Virus Research Training for West African Countries with Widespread Transmission of Ebola- Guinea, Liberia, and Sierra Leone (D71TW010411), that has allowed us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Combining this with our extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades managing institutional research, training, and capacity-building grants; we propose here our comprehensive research training plan in response to PAR-18-840-Global Infectious Disease Research Training. We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone (USL), College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aims are to 1) Enhance research capacity at KGH and COMAHS for the conduct of scientifically valid and ethically acceptable clinical trials, with a focus on Ebola, Lassa, and other VHF; 2) Strengthen and expand the KGH and COMAHS research pool with a focus on Implementation Science research for the clinical management of patients with VHF; and 3) Nurture innovative mentored research by PREVSL trainees/alumni to address the clinical management of VHF. Our comprehensive training program will consist of a combination of (1) long-term Masters training in clinical investigation with a focus on vaccine clinical trial capacity; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research through in-country short courses and Masters training in Public Health; and (4) sustainable capacity building at KGH and COMAHS for the management and administration of future research grant opportunities.

项目概要/摘要：近期埃博拉疫情暴露了塞拉利昂卫生系统的脆弱性 并强调迄今为止支持运作良好的系统所需的投资不足 能够应对如此大规模的疾病暴发，改善优质卫生服务的提供。 对于拉沙热（LF）等地方性病毒性出血热（VHF）患者，同时加强 在塞拉利昂埃博拉等未来 VHF 流行病爆发期间进行临床试验的能力必须增强 其合格的卫生专业人员库具有科学实施的方法技能和 进行临床试验。 我们刚刚完成了西非新发流行病毒研究培训规划拨款 埃博拉病毒广泛传播的国家——几内亚、利比里亚和塞拉利昂 (D71TW010411)， 使我们能够评估国内合作伙伴组织的现有研究能力，同时完善我们的研究能力 将此与我们广泛的知识相结合，找出解决这一能力差距的最佳方法的策略。 在塞拉利昂进行 VHF 研究以及管理近二十年的机构的历史； 研究、培训和能力建设补助金；我们在此提出全面的研究培训计划 响应 PAR-18-840-全球传染病研究培训。 我们寻求大幅提高塞拉利昂校长的科学实施研究能力 塞拉利昂大学医学院 (USL) 医学与联合健康科学学院 （COMAHS）以及凯内马政府医院（KGH）的临床试验基础设施 拟议的塞拉利昂新发病​​毒感染研究伙伴关系（PREVSL）[宣布 “上一页锡尔”]。 我们的具体目标是 1) 增强 KGH 和 COMAHS 的研究能力，以进行科学的研究 有效且道德上可接受的临床试验，重点关注埃博拉、拉沙和其他甚高频 (VHF) 2) 加强和 扩大 KGH 和 COMAHS 研究库，重点关注临床的实施科学研究 VHF 患者的管理；以及 3) 培育 PREVSL 学员/校友的创新指导研究 为了解决 VHF 的临床管理问题，我们的综合培训计划将包括以下内容： (1) 临床研究方面的长期硕士培训，重点是疫苗临床试验能力；(2) 短期临床研究培训； 中期临床试验管理培训，加强南南合作并建立区域 (3) 卫生服务实施科学研究的短期和长期能力建设 公共卫生领域的国内短期课程和硕士培训；以及 (4) KGH 的可持续能力建设 COMAHS 负责未来研究资助机会的管理和管理。