Childhood Cancer Survivor Study

儿童癌症幸存者研究

• 批准号: 7664971
• 负责人: LESLIE L ROBISON
• 金额: $ 189.37万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-20 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664971
• 关键词: Address; Adolescent; Advertising; Age; Behavioral; Biological; Blood specimen; Cancer Control; Cancer Survivor; Cardiovascular system; Cells; Child; Childhood; Childhood Cancer Survivor Study; Clinical; Cohort Studies; Collaborations; DNA; Data; Data Set; Diagnosis; Discipline; Disease; Early Diagnosis; Endocrine; Enrollment; Exposure to; Foundations; Functional disorder; Funding; Future; Genetic Predisposition to Disease; Genomics; Guidelines; Health Status; International; Investigation; Late Effects; Life; Link; Long-Term Survivors; Lung; Malignant Childhood Neoplasm; Malignant Neoplasms; Marketing; Minority Groups; Morbidity - disease rate; Nature; New Agents; Outcome; Participant; Peer Review; Persons; Population; Population Study; Prevention; Procedures; Publications; Quality of life; Radiation; Recruitment Activity; Relative (related person); Research; Research Personnel; Resources; Risk; Sampling; Second Primary Neoplasms; Siblings; Societies; Source; Specimen; Subgroup; Survival Rate; Survivors; Susceptibility Gene; Testing; Therapeutic; Therapeutic Intervention; Treatment Protocols; United States National Institutes of Health; arthropathies; bone; cancer diagnosis; chemotherapy; childhood cancer survivor; cohort; design; follow-up; gene therapy; health related quality of life; high risk; improved; innovation; insight; lymphoblastoid cell line; meetings; mortality; organizational structure; outcome forecast; peripheral blood; population health; programs; psychosocial; success; tumor; Address; Adolescent; Advertising; Age; Behavioral; Biological; Blood specimen; Cancer Control; Cancer Survivor; Cardiovascular system; Cells; Child; Childhood; Childhood Cancer Survivor Study; Clinical; Cohort Studies; Collaborations; DNA; Data; Data Set; Diagnosis; Discipline; Disease; Early Diagnosis; Endocrine; Enrollment; Exposure to; Foundations; Functional disorder; Funding; Future; Genetic Predisposition to Disease; Genomics; Guidelines; Health Status; International; Investigation; Late Effects; Life; Link; Long-Term Survivors; Lung; Malignant Childhood Neoplasm; Malignant Neoplasms; Marketing; Minority Groups; Morbidity - disease rate; Nature; New Agents; Outcome; Participant; Peer Review; Persons; Population; Population Study; Prevention; Procedures; Publications; Quality of life; Radiation; Recruitment Activity; Relative (related person); Research; Research Personnel; Resources; Risk; Sampling; Second Primary Neoplasms; Siblings; Societies; Source; Specimen; Subgroup; Survival Rate; Survivors; Susceptibility Gene; Testing; Therapeutic; Therapeutic Intervention; Treatment Protocols; United States National Institutes of Health; arthropathies; bone; cancer diagnosis; chemotherapy; childhood cancer survivor; cohort; design; follow-up; gene therapy; health related quality of life; high risk; improved; innovation; insight; lymphoblastoid cell line; meetings; mortality; organizational structure; outcome forecast; peripheral blood; population health; programs; psychosocial; success; tumor

DESCRIPTION (provided by applicant): Survival rates for many of the childhood and adolescent cancers have improved at a remarkable pace over the past 35 years. With this success has come the need and responsibility to consider the long-term morbidity and mortality associated with the treatments responsible for the increases in survival, the resource represented by the Childhood Cancer Survivor Study (CCSS) is the result of a multi-institutional collaboration and represents the single most comprehensive body of information ever assembled on the health status of long-term survivors. CCSS has successfully established and followed 14,370 five-year survivors of childhood and adolescent cancer diagnosed between 1970-1986 and a sample of 3,737 sibling controls. CCSS participants, derived through 26 participating clinical centers, have been characterized relative to cancer diagnosis, therapy received and health and quality of life-related outcomes encompassing over 248,000 person-years of follow-up. CCSS has established an effective organizational structure to direct the scientific and administrative functions of this unique resource. The CCSS resource has been utilized by investigators from a broad range of disciplines, including inquiries from 82 investigators new to CCSS, with 56 subsequently becoming involved in research initiatives. As a resource, CCSS produced 41 peer-reviewed publications during current funding period and has been the source of 14 investigator-initiated projects with independent funding in excess of $9,000,000 from NIH (n=6) and non-governmental agencies/foundations (n=8). The objectives of this competitive renewal are to: (1.) maintain the strong and productive resource of the CCSS through continued follow-up of the initial population, diagnosed between 1970-86; (2.) enhance the CCSS resource by recruiting 14,800 5-year survivors diagnosed between 1987-99 and 4000 sibling controls; and, (3.) promote and facilitate the use of the CCSS resource including the study participants, as well as data and biological samples previously collected for investigator-initiated studies that address important questions relating to childhood cancer survivors. Within the framework of defined guidelines and procedures, aggressive new initiatives will be undertaken to increase access/utilization of CCSS as a resource by (a) markedly increasing visibility through publications, presentations at national/international meetings, links with websites, direct marketing, and establishment of liaisons with professional societies; and (b) implementing an innovative strategy of establishing a comprehensive public-use data set. CCSS provides a dynamic framework and resource to investigate current and future questions among childhood cancer survivors.

描述（由申请人提供）：在过去的35年中，许多童年和青少年癌症的生存率都以显着的速度提高。随着这一成功，需要和责任考虑与负责增加生存的治疗相关的长期发病率和死亡率，儿童癌症幸存者研究（CCSS）代表的资源是多机构合作的结果，代表了有史以来最全面的信息体系，这些信息是有史以来最全面的信息体系。 CCSS已成功建立，并在1970 - 1986年间被诊断出的儿童和青少年癌症的14,370名五年幸存者和3,737个同胞对照样本中诊断出来。 CCSS参与者通过26个参与临床中心得出，相对于癌症诊断，接受的治疗以及与生活相关的结局的健康和质量，包括超过248,000人的随访。 CCSS建立了一种有效的组织结构，以指导这种独特资源的科学和行政功能。 CCSS资源已被广泛学科的调查人员利用，包括来自CCSS的82名调查人员的询问，随后有56名参与了研究计划。作为一种资源，CCSS在当前的资金期间生产了41个经过同行评审的出版物，并且已成为14个调查员发起的项目的来源，独立资金超过了NIH（n = 6）和非政府机构/基金会（n = 8）。这种竞争性更新的目标是：（1。）通过持续对1970 - 86年间诊断的初始人口进行随访，以保持CCSS的强大和生产力； （2.）通过招募1987 - 99年至4000个同胞控制的14,800名5年幸存者来增强CCSS资源； （3。）促进和促进CCSS资源的使用，包括研究参与者，以及先前收集的数据和生物样品，用于研究人员发起的研究，这些研究解决了与儿童癌症幸存者有关的重要问题。在定义的准则和程序的框架内，将采取积极的新举措，以通过（a）通过出版物，在国家/国际会议上的出版物，与网站联系，直接营销和与专业社会建立LIAISON的网站联系，通过（a）明显提高CCSS作为资源的访问/利用； （b）实施建立全面的公共用途数据集的创新策略。 CCSS提供了一个动态的框架和资源，以调查儿童癌症幸存者的当前和未来问题。