National Mesothelioma Virtual Bank for Translational Research

国家间皮瘤转化研究虚拟银行

• 批准号: 7684024
• 负责人: MICHAEL JOHN BECICH
• 金额: $ 100万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684024
• 关键词: National; Mesothelioma; Virtual; Bank; Translational

DESCRIPTION (provided by applicant): The National Mesothelioma Virtual Bank (NMVB) for Translational Research has created and maintains a national virtual patient registry and research resource bank. To date the NMVB has made available over 400 unique cases to share with the research community. NMVB now proposes to expand their innovative resources through a cooperative working group that broadly shares their mesothelioma research tools. The NMVB database is used for clinical and outcomes data collection related to each research resource (serum, plasma, tissue, pleural effusions, tissue microarrays, whole slide images, proteomic/genomic data and other resources - see specific aim 1). Each NMVB partner will be responsible for the data entry and updates into the registry for each of their research resources on a web based database developed in Pittsburgh which has its foundation in tools from the NCI Cancer Biomedical Informatics Grid (caBIG) effort. The registry has been established and managed by the University of Pittsburgh team in collaboration with New York University, the University of Pennsylvania and the Meso Foundation via a CDC NIOSH cooperative agreement. We intend to significantly expand the network to include the National Functional Genomics Center and the Cooperative Human Tissue Network, as well as other organizations who are interested in sharing their research resources. In addition to actively publicizing the availability of this resource to prospective users in the research community, the Meso Foundation will collaborate with the NMVB to develop a virtual patient registry (see specific aim 2) that will allow researchers to access the patients affected by mesothelioma for clinical and translational research studies. Meso Foundation is well positioned to do this and can capitalize on its deep linkages to the patient advocacy community to create a dialogue with this deeply vested population. Marketing, outreach and evaluation of the NMVB's impact on translational research will be accomplished by partnering with the Meso Foundation (see specific aim 3). In summary, we intend to continue to expand our network to at least 1200 cases for translational research as well as develop a unique patient registry for recruiting those afflicted with mesothelioma. This expansion of the NMVB will provide unique and innovative tools to aid in the prevention, early detection and treatment of this uniformly fatal disease.

描述（由申请人提供）：用于转化研究的国家间皮瘤虚拟银行 (NMVB) 创建并维护了一个国家虚拟患者登记和研究资源库。迄今为止，NMVB 已提供 400 多个独特案例与研究界分享。 NMVB 现在提议通过一个广泛共享其间皮瘤研究工具的合作工作组来扩大其创新资源。 NMVB 数据库用于收集与每个研究资源（血清、血浆、组织、胸腔积液、组织微阵列、全玻片图像、蛋白质组/基因组数据和其他资源 - 参见具体目标 1）相关的临床和结果数据。每个 NMVB 合作伙伴将负责在匹兹堡开发的基于网络的数据库中输入和更新其每项研究资源的数据，该数据库以 NCI 癌症生物医学信息网格 (caBIG) 工作的工具为基础。该注册表由匹兹堡大学团队通过 CDC NIOSH 合作协议与纽约大学、宾夕法尼亚大学和 Meso 基金会合作建立和管理。我们打算大幅扩展该网络，以包括国家功能基因组学中心和人体组织合作网络，以及有兴趣共享其研究资源的其他组织。除了积极向研究界的潜在用户宣传该资源的可用性外，Meso 基金会还将与 NMVB 合作开发一个虚拟患者登记处（参见具体目标 2），使研究人员能够接触到受间皮瘤影响的患者，以了解他们的情况。临床和转化研究。 Meso 基金会完全有能力做到这一点，并且可以利用其与患者倡导社区的深厚联系，与这些既得利益群体建立对话。 NMVB 对转化研究影响的营销、推广和评估将通过与 Meso 基金会合作来完成（参见具体目标 3）。总之，我们打算继续将我们的网络扩大到至少 1200 例转化研究病例，并开发一个独特的患者登记库来招募患有间皮瘤的患者。 NMVB 的扩展将提供独特和创新的工具，以帮助预防、早期发现和治疗这种致命的疾病。