Visible Light Photocatalysis

可见光光催化

基本信息

批准号：
10380452
负责人：
TEHSHIK P YOON
金额：
$ 3.76万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2022-11-30
项目状态：
已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Photochemical synthesis represents an exciting frontier for drug discovery and for biomedical research. The ability of small, structurally complex organic molecules to interact with biomolecules and perturb their behavior is at the heart of modern molecular medicine and chemical biology. The discovery of new drugs and biological probes with new properties, therefore, relies critically upon the synthesis of new molecules with unprecedented structures. Photochemistry has long been an underdeveloped technique in chemical synthesis, in part because the irradiation of organic molecules with light results in the generation of highly reactive, high-energy species that can react indiscriminately and unproductively. We are investigating the ways in which addition of various reagents to photochemical reactions can control these photogenerated intermediates in diverse ways. In this proposal, we describe two Specific Aims to study how these reagents can result in powerful new bond forming methods. Aim 1. We are exploring the ability of chiral catalysts to control the stereochemistry of photochemical reactions. Aim 2. We are exploring the ability of copper oxidants to enable the installation of functional groups onto simple unfunctionalized organic scaffolds. These methods enable chemical transformations that cannot otherwise be accomplished using conventional, non-photochemical technologies. Thus, we expect that the results of our research will have significant impacts both in fundamental academic chemical research and on the ability of biomedical scientists to synthesize and discover the next generation of life-saving drugs.

项目概要/摘要光化学合成代表了药物发现和生物医学研究的一个令人兴奋的前沿领域。这结构复杂的小有机分子与生物分子相互作用并扰乱其生物分子的能力行为是现代分子医学和化学生物学的核心。新药的发现因此，具有新特性的生物探针关键依赖于新分子的合成具有前所未有的结构。光化学长期以来一直是化学领域中一项不发达的技术合成，部分原因是有机分子用光照射会产生高度反应性高能物质，可以不加区别地发生无效反应。我们正在研究如何在光化学反应中添加各种试剂来控制这些光生中间体以多种方式产生。在本提案中，我们描述了两个具体目标研究这些试剂如何产生强大的新成键方法。目标1.我们正在探索手性催化剂控制光化学立体化学的能力反应。目标 2. 我们正在探索铜氧化剂将官能团安装到简单的非功能化有机支架。这些方法能够实现使用其他方法无法完成的化学转化传统的非光化学技术。因此，我们期望我们的研究结果能够对基础学术化学研究和生物医学能力产生重大影响科学家们合成和发现下一代救命药物。