Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging

用于体内放射自显影成像的超高分辨率脑 PET 扫描仪

基本信息

批准号：
9791189
负责人：
Georges El Fakhri
金额：
$ 79.12万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9791189
关键词：
Adult Afferent Pathways Altropane Alzheimer&apos s Disease Area Autoradiography Basal Ganglia Benchmarking Brain Brain Diseases Brain imaging Calibration Catecholamines Cell Nucleus Clinical Clinical Research Cognitive Crystallization Custom Data Deposition Detection Devices Disease Progression Dopamine Ensure Event Human Image Imagery Investigation Kinetics Methods Motion Neurons Neurosciences Neurotransmitters Optics Parkinson Disease Participant Patients Performance Physiological Positioning Attribute Positron Positron-Emission Tomography Recovery Research Resolution Source Structure Substantia nigra structure Symptoms System Technology Testing Tissues Ventral Tegmental Area aged attenuation base design detector dopamine transporter entorhinal cortex experimental study healthy aging healthy volunteer high resolution imaging human imaging human subject improved in vivo lens member monitoring device neuroimaging next generation parametric imaging radiotracer reconstruction research study response simulation tau Proteins tau aggregation tomography ultra high resolution young adult

项目摘要

We propose to design, build, and evaluate the Scanner Approaching in Vivo Autoradiographic Neuro Tomography (SAVANT), a next generation PET scanner for ultra-high resolution imaging of the human brain using hardware advances developed by members of our collaborative team to achieve unprecedented spatial resolution and count rate capabilities. The system will have a volumetric resolution close to 1 mm3 (isotropic spatial resolution close to 1 mm), which is approximately 27 fold better than the best dedicated brain PET scanners and 125 fold better than general purpose PET scanners. Such an improvement will allow visualization and quantification of in vivo physiological events as never before possible, such as deposition of tau neurofibrillary tangles in the entorhinal cortex in the prodromal stages of Alzheimer's disease and dopamine transporter concentration in the substantia nigra and ventral tegmental area. This will allow the detection and quantitation of brain disease at a much earlier stage, decades before onset of clinical symptoms, and permit the study of key structures in neurotransmitter systems that currently cannot be imaged accurately with PET. The proposed high resolution PET scanner will be validated in phantom studies and performance evaluated in healthy volunteers.

我们建议设计、构建和评估体内接近扫描仪放射自显影神经断层扫描 (SAVANT)，下一代 PET 扫描仪利用硬件进步对人脑进行超高分辨率成像由我们的协作团队成员开发，以实现前所未有的空间分辨率和计数率能力。系统将具有体积分辨率接近 1 mm3（各向同性空间分辨率接近 1 mm），大约为比最好的专用脑 PET 扫描仪好 27 倍，比最好的专用脑部 PET 扫描仪好 125 倍通用 PET 扫描仪。这样的改进将允许可视化和前所未有地量化体内生理事件，例如前驱期 tau 神经原纤维缠结在内嗅皮层沉积阿尔茨海默病的阶段和多巴胺转运蛋白浓度黑质和腹侧被盖区。这将允许检测和在临床发病前数十年的早期阶段对脑部疾病进行定量症状，并允许研究神经递质系统的关键结构目前 PET 无法准确成像。拟议的高分辨率 PET 扫描仪将在模型研究中得到验证，并在健康中评估性能志愿者。