Predictions of Response to Treatment in Fungal Keratitis

真菌性角膜炎治疗反应的预测

• 批准号: 9334594
• 负责人: Jennifer Rose-Nussbaumer
• 金额: $ 23.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334594
• 关键词: Address; Adjuvant; Affect; Age; Antifungal Agents; Antimicrobial Effect; Aspergillus; Bacteria; Biological Preservation; Biometry; Blindness; Cataract; Characteristics; Climate; Clinical; Clinical Trials; Collagen; Cornea; Corneal Opacity; Corneal Ulcer; Data; Development; Development Plans; Disease; Dose; Enrollment; Epidemiology; Ethiopia; Etiology; Fellowship; Funding; Fusarium; Goals; Grant; HIV; In Vitro; Incidence; India; Infection; International; Keratitis; Keratoplasty; Learning; Literature; Los Angeles; Measures; Mentorship; Molds; Monocular Blindness; Mycoses; Nepal; Ophthalmologist; Ophthalmology; Oral; Organism; Outcome; Participant; Patients; Pattern; Perforation; Pharmaceutical Preparations; Placebos; Prediction of Response to Therapy; Predisposition; Principal Investigator; Prospective cohort study; Randomized Clinical Trials; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Resistance; Risk; SECTM1 gene; Site; Subgroup; Testing; Therapeutic; Time Study; Tissues; Trachoma; Training; Trauma; Ulcer; United States; Vision research; Visual Acuity; Voriconazole; Work; World Health Organization; career development; crosslink; design; educational atmosphere; experience; fungus; improved; in vivo; interest; meetings; multidisciplinary; practical application; predict clinical outcome; public health relevance; randomized trial; secondary analysis; treatment response; treatment trial; trial design

 DESCRIPTION (provided by applicant): Candidate. I am a cornea fellowship trained ophthalmologist who would like to gain additional experience in epidemiology, bio-statistical analysis and implementation of randomized controlled trials by pursuing a K23 grant. My long-term goal is to become an independent investigator with a focus on design of randomized controlled trials in cornea. I currently hold a K12 through UC Berkeley to study fungal corneal ulcer treatment in India and Nepal. In addition, I am researching corneal transplant outcomes in Ethiopia and am the Principal Investigator on the Corneal Preservation Time study at UCSF. My previous vision research in ophthalmology includes work with the World Health Organization on Trachoma, as well as investigating the ocular manifestations of HIV disease. Research Strategy. Fungal keratitis is a major cause of monocular blindness in the developing world. The best treatment of fungal keratitis has not been well characterized. The Mycotic Ulcer Treatment Trials (MUTT I and II) are two NEI-funded randomized trials designed by our group to determine the best available treatment of fungal keratitis. The goal of my K23 is to perform secondary analyses of the trial data to determine whether organism, in vitro antifungal activity and other presentation characteristics predict in vivo efficacy in the treatment of fungal corneal ulcers. Career Development Plan. I will gain applied experience by working on this research under the excellent mentorship of Tom Lietman MD, Nisha Acharya MD, Stephen Mcleod MD and Hobart Harris MD. UCSF/Proctor has multiple large clinical trials in different stages of development, recruitment and analysis. As I will also have the opportunity to get involved in these studies, Proctor provides the ideal learning environment for me. During the course of my training grant I will conduct a prospective cohort study looking at the efficacy of collagen cross-linking in the treatment of infectious keratitis. In addition, I will participate in the Training in Clinical Reserch (TICR) courses offered by the UCSF Department of Epidemiology and Biostatistics, as well as weekly meetings with the multi-disciplinary Proctor International Research Group where I will learn practical applications of clinical trial research.

 描述（由申请人提供）：我是一名接受过角膜专科培训的眼科医生，希望通过寻求 K23 资助来获得流行病学、生物统计分析和随机对照试验实施方面的额外经验。一位专注于角膜随机对照试验设计的独立研究者，我目前通过加州大学伯克利分校获得 K12 学位，研究印度和尼泊尔的真菌性角膜溃疡治疗。我是埃塞俄比亚大学角膜保存时间研究的首席研究员。我之前的眼科视力研究包括与世界卫生组织合作研究沙眼，以及研究艾滋病毒疾病的眼部表现。真菌性溃疡治疗试验（MUTT I 和 II）是发展中国家单眼失明的一个主要原因。我们小组设计的随机试验，以确定真菌性角膜炎的最佳可用治疗方法。我的 K23 的目标是对试验数据进行二次分析，以确定生物体、体外抗真菌活性和其他表现特征是否可以预测治疗的体内疗效。我将在 Tom Lietman 医学博士、Nisha Acharya 医学博士、Stephen Mcleod 医学博士和 Hobart Harris 医学博士的出色指导下获得应用经验。由于我也将有机会参与这些研究的不同阶段的大型临床试验，Proctor 为我提供了理想的学习环境。在我的培训资助期间，我将进行前瞻性队列研究。研究探讨胶原蛋白交联在治疗感染性角膜炎中的功效。此外，我还将参加 UCSF 流行病学和生物统计学系提供的临床研究培训 (TICR) 课程，以及每周与该部门举行的会议。多学科普罗克特国际研究小组，我将在那里学习临床试验研究的实际应用。