Electro-optic adaptive eyeglass for correction of presbyopia

矫正老花眼的电光自适应眼镜

• 批准号: 7993737
• 负责人: Guoqiang Li
• 金额: $ 28.64万
• 依托单位: UNIVERSITY OF MISSOURI-ST. LOUIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7993737
• 关键词: Adopted; Area; Astigmatism; Automobile Driving; Boxing; Caliber; Caring; Clinical Research; Computers; Contrast Sensitivity; Devices; Distant; Dizziness; Electronics; Elements; Eye; Eyeglasses; Feedback; Goals; Human; Intraocular lens implant device; Light; Manuals; Measures; Methods; Mono-S; Myopia; Ophthalmologist; Optics; Patients; Performance; Phase; Population; Presbyopia; Quality of life; Reaction Time; Reading; Refractive Errors; Research; Scanning; System; Techniques; Time; Vision; Visual Acuity; Visual impairment; adaptive optics; age related; bioimaging; cost; design; gaze; improved; lens; light weight; liquid crystal; meetings; novel; novel strategies; operation; practical application; prototype; public health relevance; simulation; visual performance; voltage; Adopted; Area; Astigmatism; Automobile Driving; Boxing; Caliber; Caring; Clinical Research; Computers; Contrast Sensitivity; Devices; Distant; Dizziness; Electronics; Elements; Eye; Eyeglasses; Feedback; Goals; Human; Intraocular lens implant device; Light; Manuals; Measures; Methods; Mono-S; Myopia; Ophthalmologist; Optics; Patients; Performance; Phase; Population; Presbyopia; Quality of life; Reaction Time; Reading; Refractive Errors; Research; Scanning; System; Techniques; Time; Vision; Visual Acuity; Visual impairment; adaptive optics; age related; bioimaging; cost; design; gaze; improved; lens; light weight; liquid crystal; meetings; novel; novel strategies; operation; practical application; prototype; public health relevance; simulation; visual performance; voltage

DESCRIPTION (provided by applicant): Presbyopia is an age-related loss of accommodation of the human eye that manifests itself as inability to shift focus from distant to near objects. More than 90% of the people over 45 need correction of presbyopia. The conventional corrective lenses (bifocal, trifocal) have been around for more than 200 years and have some drawbacks. They have a limited field of view for each vision task, requiring user to gaze down to accomplish near vision and in some cases causing dizziness and discomfort. Some users need three different eyeglasses for reading, computer, and driving. Progressive lenses cause some distortion. Recently we have demonstrated switchable diffractive liquid crystal (LC) lens with binary ON and OFF states. In the proposed project, our goal is to develop a tunable, low-cost electro-optic lens with continuous focusing powers and high optical performance for near-, intermediate-, and distance vision. The whole aperture with the same power is used for each vision task. Such a device may have revolutionary impact on the field of vision care. Existing LC lenses have an aperture of 10-15 mm, and the power can only be switched between plano and 1 diopter (D) (or 2D). The driver box is 4W4W2 cm3, which is bulky. They are not suitable for practical ophthalmic applications. In this study, we will develop a novel, high performance, cost-effective varifocal LC lens with a compact electronic driver and controller. The focusing power of the lens can be continuously tuned from plano to +4D by applied voltages. This range covers the typical add powers needed for presbyopes, and it allows almost all patients to use the same lens. We will fabricate lenses with an aperture around 40mm, which satisfies the requirement for practical applications. The light efficiency will be close to 100%. These three specifications have not been met before. We will design a novel closed-loop driver circuit with good reliability and high power efficiency. In addition, we will develop a minicontroller that allows change of the focus power by simply pressing a button, which is practical and reliable; in the second phase of this project, we will develop a prototype of the eyeglass that allows autofocus function. The size of the driver will be only 5W5W2 mm3. Clinical studies will be performed to assess how the wearers function and perceive the new spectacles. This kind of lens is promising to become an alternative of conventional area division multi-focal spectacle lenses used by presbyopes. They may have the potential of revolutionizing the field of presbyopia correction. The new eyeglass will significantly improve the quality of life for a large population. Applications can be extended to fields where varifocal lens elements with low operation voltages, relatively large diameters and fast response time are desirable. For example, a single lens of this kind can be used as a new phoropter to measure the refractive errors and visual acuity and for rapid depth scanning in three-dimensional biomedical imaging. Correction of low vision with high quality optics in the periphery will also have high impact. This would be our next focus of research. PUBLIC HEALTH RELEVANCE: The proposed electro-optic adaptive eyeglass allows correction of near-, intermediate-, and distance vision. The lens has high diffraction efficiency, larger aperture, large tunable range, high optical quality, good response time, and low driving voltages. The focusing power can be continuously tuned by the applied voltages. The cost can be comparable or lower than progressive lenses. This kind of lens is promising to replace conventional area-division multi-focal spectacle lenses used by presbyopes. They have the potential of revolutionizing the field of presbyopia correction. Needlessly to say, the new eyeglass will significantly improve the quality of life for a large portion of the population. Applications can be extended to fields where varifocal lens elements with low operation voltages, relatively large diameters and fast response time are desirable. For example, a single lens of this kind can be used as a new phoropter to measure the refractive errors and visual acuity. The current phoropters are bulky and require the ophthalmologist/technician to manually adjust the add lenses, which is also time consuming. The new phoropter is compact, light weight, and easy to use. Correction of low vision with high quality optics in the periphery will also have high impact. This would be our next focus of research.

描述（由申请人提供）：长老会是与年龄相关的人眼的丧失，表现为无法将重点从遥远的物体转移到近对象。超过45岁以上的人中有90％需要对长老会进行纠正。常规的纠正镜（双焦点，三灶）已经存在了200多年，并且有一些缺点。他们对每个视觉任务的视野有限，要求用户凝视以完成近视，在某些情况下会导致头晕和不适。一些用户需要三种不同的眼镜才能阅读，计算机和驾驶。进行性镜头会导致一些失真。最近，我们证明了具有二元开关状态的可切换衍射液晶（LC）镜头。在拟议的项目中，我们的目标是开发具有连续聚焦功能的可调，低成本的电晶晶状体，并具有近距离，中间和距离视觉的高光学性能。每个视觉任务都使用具有相同功率的整个光圈。这样的设备可能会对视力护理领域产生革命性的影响。现有的LC镜头的光圈为10-15毫米，并且功率只能在Plano和1 Diopter（D）（或2D）之间切换。驾驶员盒为4W4W2 cm3，很大。它们不适合实用的眼科应用。在这项研究中，我们将开发一种具有紧凑的电子驱动器和控制器的新型，高性能，具有成本效益的Varifocal LC镜头。镜头的聚焦能力可以通过施加电压连续调节到 +4D。该范围涵盖了长老会所需的典型添加功率，并且几乎所有患者都可以使用相同的镜头。我们将用大约40mm的光圈制造镜片，这满足了对实际应用的需求。光效率将接近100％。这三个规格以前尚未满足。我们将设计一个具有良好可靠性和高功率效率的新型闭环驾驶员电路。此外，我们还将开发一个微型控制器，通过简单地按下一个实用且可靠的按钮来更改焦点功率；在该项目的第二阶段，我们将开发一个允许自动对焦函数的眼镜的原型。驾驶员的大小仅为5W5W2 mm3。将进行临床研究，以评估佩戴者如何运作和感知新眼镜。这种镜头有望成为长老会使用的常规区域分区多焦点镜镜头的替代方法。他们可能具有彻底改变长老会更正领域的潜力。新的眼镜将显着改善大量人群的生活质量。应用可以扩展到具有低操作电压，相对较大的直径和快速响应时间的杂色镜头元件的字段。例如，此类镜头可以用作新的phoropter，以测量折射率和视敏度以及在三维生物医学成像中快速扫描的快速深度扫描。在外围的高质量光学器件对低视力的校正也将产生很高的影响。这将是我们的下一个研究重点。 公共卫生相关性：拟议的电形自适应眼镜允许校正近，中间和远程视觉。镜头具有高衍射效率，较大的光圈，较大的可调节范围，高光学质量，良好的响应时间和低驾驶电压。可以通过施加的电压连续调节聚焦功率。成本可以比较近似或低于渐进镜头。这种镜头有望取代长老会使用的常规区域分区多焦点镜头。他们有可能改变长老会纠正领域的潜力。不用说，新的眼镜将显着改善大部分人口的生活质量。应用可以扩展到具有低操作电压，相对较大的直径和快速响应时间的杂色镜头元件的字段。例如，这种镜头可以用作新的phoropter，以测量折射误差和视力。当前的phoropter笨重，要求眼科医生/技术人员手动调整添加镜头，这也很耗时。新的Phoropter紧凑，重量轻，易于使用。在外围的高质量光学器件对低视力的校正也将产生很高的影响。这将是我们的下一个研究重点。