Fungal infections and tolerogenic immunosuppression

真菌感染和耐受性免疫抑制

• 批准号: 7942337
• 负责人: Fernanda P. Silveira
• 金额: $ 9.07万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942337
• 关键词: Fungal; infections; tolerogenic; immunosuppression

Description (provided by applicant): A major cause of mortality in transplant recipients is fungal infection. One aim of the CDC is to determine the epidemiology of fungal infections in transplant recipients, with a view to developing strategies aimed at preventing such infections. A major thrust of this project will be to perform surveillance for fungal infections so that the epidemiology can be precisely determined. Transplant immunosuppressive regimens are undergoing a paradigm shift whereby immunosuppression reaches levels seen in advanced AIDS (CD4 counts of less than 50 Cells/mm3) in the early months post transplant and then is significantly reduced for the remainder of the life of the transplant recipient. The study of fungal infections in this setting is particularly important. Although one strategy of prevention is use of prophylactic antifungal agents, an alternative approach is to find a means of diagnosis of fungal infections while they are still at a treatable stage. Therefore, another major aim of the study is to serially collect serum and urine on consecutive transplant recipients with a view to having a "bank" on which to test new diagnostic methodologies.

描述（由申请人提供）：移植受者死亡的一个主要原因是真菌感染。疾病预防控制中心的目标之一是确定移植受者中真菌感染的流行病学，以期制定旨在预防此类感染的策略。该项目的一个主要目标是对真菌感染进行监测，以便准确确定流行病学。移植免疫抑制方案正在经历范式转变，即免疫抑制在移植后最初几个月达到晚期艾滋病（CD4 计数低于 50 个细胞/mm3）的水平，然后在移植受者的余生中显着降低。在这种情况下对真菌感染的研究尤为重要。尽管预防策略之一是使用预防性抗真菌药物，但另一种方法是找到一种在真菌感染仍处于可治疗阶段时进行诊断的方法。 因此，该研究的另一个主要目的是连续收集连续移植受者的血清和尿液，以期建立一个“库”来测试新的诊断方法。

项目成果

Management of meningitis due to antibiotic-resistant Acinetobacter species.

• DOI: 10.1016/s1473-3099(09)70055-6
• 发表时间: 2009-04
• 期刊: LANCET INFECTIOUS DISEASES
• 影响因子: 56.3
• 作者: Kim, Baek-Nam;Peleq, Anton Y.;Lodise, Thomas P.;Lipman, Jeffrey;Li, Jian;Nation, Roger;Paterson, David L.
• 通讯作者: Paterson, David L.