Southern California Primary Infection Program

南加州初级感染计划

• 批准号: 7931675
• 负责人: DOUGLAS D RICHMAN
• 金额: $ 1.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-21 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931675
• 关键词: Acute; Anti-Retroviral Agents; Apoptosis; Arts; Autologous; CD8B1 gene; California; Collaborations; Communication; Consensus; Databases; Generations; HIV; HIV Infections; HIV drug resistance; Immune response; Infection; Information Dissemination; Length; Longitudinal Studies; Los Angeles; Methods; Mutation; Natural History; Pathogenesis; Pharmaceutical Preparations; Population Biology; Preparation; Proliferating; Reading Frames; Relative (related person); Research Personnel; Resources; Role; Series; Site; System; Technology; Therapeutic Intervention; Training and Education; Vaccines; Virus; cohort; data management; design; genital secretion; neutralizing antibody; prevent; programs; prophylactic; response; therapeutic vaccine; transmission process

DESCRIPTION (provided by applicant): The Southern California Primary Infection Program includes sites in San Diego and Los Angeles with a track record of identifying substantial cohorts with acute and early HIV infection. These cohorts have participated in longitudinal studies of natural history, pathogenesis, and therapeutic interventions with both antiretroviral drugs and vaccines. A series of excellent collaborations have resulted in completed studies characterizing HIV dynamics, apoptosis, CTL and CD4 proliferate responses, neutralizing antibody, and transmission of HIV drug resistance. These studies consist of both site and AIEDRP-wide studies coordinated in San Diego. Ongoing and proposed studies include the characterization of CD4 and CD8 responses to full length HIV reading frames, the relative contributions of immune responses to consensus and autologous sequences of HIV, the generation of neutralizing antibody (nAb) responses to autologous virus, the emergence of escape mutations over the full length sequence of HIV to each of these immune responses, the role of Nef in CTL control of HIV infection and escape from it, the population biology of HIV in genital secretions, and the dynamics of latent HIV infection in primary infection. We have also coordinated an additional AIEDRP-wide study of CTL responses in preparation for a therapeutic vaccine study. These studies will not only help to better characterize the natural history and pathogenesis of primary HIV infection, they will provide invaluable information to design strategies to prevent HIV transmission, to reduce secondary HIV drug resistance and to design and evaluate strategies for both prophylactic and therapeutic vaccines. A major component of this application is also the commitment to provide a state-of-the-art data management system and methods capable of supporting the projects of multiple local investigators as well as complimenting the resources of the central AIEDRP database. We will develop a set of on-line resources and communications technologies that facilitate scholarly exchange, distance-independent collaboration, information dissemination, education and training.

描述（由申请人提供）：南加州的主要感染计划包括圣地亚哥和洛杉矶的地点，其记录是鉴定出具有急性和早期HIV感染的大量队列。这些队列参与了抗逆转录病毒药物和疫苗的自然病史，发病机理和治疗性干预措施的纵向研究。一系列出色的合作导致完成了表征HIV动力学，凋亡，CTL和CD4增殖反应，中和抗体以及HIV耐药性传播的完整研究。这些研究包括在圣地亚哥协调的地点和AIEDRP范围的研究。 Ongoing and proposed studies include the characterization of CD4 and CD8 responses to full length HIV reading frames, the relative contributions of immune responses to consensus and autologous sequences of HIV, the generation of neutralizing antibody (nAb) responses to autologous virus, the emergence of escape mutations over the full length sequence of HIV to each of these immune responses, the role of Nef in CTL control of HIV infection and escape from it, the艾滋病毒在生殖器分泌中的种群生物学以及原发性感染中潜在艾滋病毒感染的动态。我们还协调了一项对CTL反应的额外的AIEDRP范围研究，为治疗性疫苗研究做准备。这些研究不仅将有助于更好地描述原发性艾滋病毒感染的自然病史和发病机理，而且还将为设计策略提供宝贵的信息，以防止HIV传播，降低二级HIV耐药性，并设计和评估预防性和治疗性疫苗的策略。本应用程序的一个主要组成部分还承诺提供一个最先进的数据管理系统和能够支持多个本地研究人员项目的方法，并补充中央AIEDRP数据库的资源。 我们将开发一系列在线资源和通信技术，以促进学术交流，独立于距离的合作，信息传播，教育和培训。