Infectious Triggers in Chronic Fatigue Syndrome

慢性疲劳综合症的感染性触发因素

基本信息

批准号：
7884022
负责人：
STEVEN E SCHUTZER
金额：
$ 27.3万
依托单位：
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7884022
关键词：
Adult Agreement American Antiviral Therapy Arthralgia Bacteria Blood Brain Cerebrospinal Fluid Cerebrum Chronic Fatigue Syndrome Data Detection Diagnosis Diagnostic Disease Early Diagnosis Etiology Exclusion Exertion Fatigue Freezing Functional disorder Genetic Healthcare Systems Impaired cognition Individual Infectious Agent Influenza Investigation Knee Knowledge Liquid substance Magnetic Resonance Imaging Medical Methodology Methods Microbe Muscle Neuraxis Neurologic Nucleic Acids Onset of illness Operative Surgical Procedures Patient Self-Report Patients Prevention Protozoa Publishing Reporting Research Personnel Sampling Signal Transduction Sleep disturbances Spinal Anesthesia Spinal Puncture Symptoms Syndrome Testing Vaccines Variant Virus base biodefense cost cystic fibrosis patients design egg experience fungus improved microbial novel novel strategies pathogen platform-independent prevent public health relevance

项目摘要

DESCRIPTION (provided by applicant): Chronic Fatigue Syndrome (CFS) is a major disabling illness of unknown etiology. It directly impacts more than four million Americans. Infectious agents have been highly suspected but none have ever been validated. Obstacles to their discovery have been lack of a broad approach that can both detect the presence of multiple microbes in a single sample and detect novel or variants of microbes. This has been further hampered because more than 99% of all microbes cannot be cultured and may go undetected. In contrast to past limitations, we will use a new approach that can surmount these obstacles. The discovery of potential pathogens in cerebrospinal fluid of CFS would be field-altering in terms of approach to the study of the disease and possible early detection, prevention and treatment. This could be the gateway step to generate new hypotheses and begin investigation into a microbe's causal association and ways to prevent (egg vaccine) or counteract the effects of a microbial pathogen. PUBLIC HEALTH RELEVANCE: Chronic Fatigue Syndrome is the major acquired disease of productive adults. The cause remains unknown. If we can uncover an infectious cause, which is suspected, diagnostics and therapies may be developed to decrease costs and suffering to the individual and the burden on our health care system and economy.

描述（由申请人提供）：慢性疲劳综合症（CFS）是一种病因不明的严重致残疾病。它直接影响超过四百万美国人。人们高度怀疑传染源，但尚未得到证实。他们的发现面临的障碍是缺乏一种广泛的方法，既可以检测单个样品中是否存在多种微生物，又可以检测微生物的新型或变体。这进一步受到阻碍，因为超过 99% 的微生物无法培养并且可能未被检测到。与过去的限制相比，我们将使用一种可以克服这些障碍的新方法。 CFS 脑脊液中潜在病原体的发现将在该疾病的研究方法以及可能的早期检测、预防和治疗方面产生重大改变。这可能是产生新假设并开始调查微生物因果关系以及预防（鸡蛋疫苗）或抵消微生物病原体影响的方法的门户步骤。公共卫生相关性：慢性疲劳综合症是生产性成年人的主要获得性疾病。原因尚不清楚。如果我们能够发现可疑的感染原因，就可以开发诊断和治疗方法，以减少个人的成本和痛苦以及我们的医疗保健系统和经济的负担。