Biopsychosocial Relationships underlying Indoor Tanning Experience: Project BRITE

室内日光浴体验背后的生物心理社会关系：BRITE 项目

• 批准号: 7991149
• 负责人: Carolyn Heckman
• 金额: $ 21.97万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7991149
• 关键词: Absence of pain sensation; Addictive Behavior; Adolescent; Affect; Affective; Age; Alcohol consumption; Alcoholism; Alleles; Analgesics; Anxiety; Appearance; Area; Awareness; Beds; Behavior; Behavior Control; Binding; Biological; Biological Markers; Biological Process; Blood; Blood specimen; Cleaved cell; Corticotropin; Crossover Design; Data; Dependence; Development; Disease; Distress; Eligibility Determination; Emotional; Emotions; Exercise; Exposure to; Feeling; Female; Freckles; Frequencies; Future; Gambling; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic screening method; Goals; Health; Hormones; Human; Individual; Interview; Investigation; Laboratories; Light; Literature; Malignant Neoplasms; Measures; Mental Depression; Modeling; Monitor; Moods; Morphine; Motivation; Obsessive compulsive behavior; Opioid; Opioid Receptor; Participant; Patient Self-Report; Placebos; Population; Prevention; Pro-Opiomelanocortin; Procedures; Process; Production; Protein p53; Psychological Interview; Public Health; Public Policy; Questionnaires; Randomized; Receptor Gene; Recruitment Activity; Relaxation; Reporting; Research; Risk; Sampling; Skin; Skin Cancer; Skin tanning; Source; Special Event; Spottings; Stress; Subgroup; Substance Addiction; Sunbathing; Symptoms; TP53 gene; Testing; Time; Tumor Suppressor Genes; UV Radiation Exposure; Ultraviolet Rays; Variant; Withdrawal; Withdrawal Symptom; Woman; Work; addiction; alpha-Melanocyte stimulating hormone; beta-Endorphin; biopsychosocial; endogenous opioids; experience; girls; high risk; innovation; keratinocyte; men; mu opioid receptors; novel; psychologic; public health relevance; response; skin cancer prevention; tanning booths; university student; young adult

DESCRIPTION (provided by applicant): As the most common human malignancy, skin cancer is a major public health concern. Ultraviolet radiation (UVR), specifically that produced by indoor tanning booths contributes significant risk for skin cancer. Indoor tanning is becoming increasingly prevalent and is particularly popular among adolescent and young adult females. While many indoor tanners tan for appearance reasons, a subgroup of frequent tanners may become psychologically and physically dependent on tanning. There is evidence that UVR exposure produces substances in the body (e.g., the opioid beta-endorphin) that may increase positive feelings and the desire to tan. The primary aim of the proposed project is to test the feasibility and acceptability of a novel experimental paradigm to investigate the affective (emotional) and biological determinants of and responses to UVR exposure that may motivate ongoing indoor tanning behavior. 18-25 year-old female frequent and infrequent indoor tanners will be recruited and randomly assigned to receive UVR and non-UVR (placebo) light from standard commercial tanning booths in a within-subjects cross-over design. Participants will complete a psychological interview, questionnaires, and blood samples before and after UVR exposure. It is hypothesized that there will be significant differences between the frequent and the infrequent indoor tanners in psychological/affective and biomarker (ACTH, beta-endorphin) baseline levels and responses to UVR exposure, as well as genetic polymorphisms (the mu-opioid receptor, OPMR1). Our team has successfully conducted several previous skin cancer prevention and addiction studies with young adults; thus, we are ideally suited and uniquely poised to conduct the proposed project. Such innovative and translational work is important to understanding the psychological and biological processes underlying the desire to tan, particularly among frequent indoor tanners who are exposed to the greatest levels of damaging UVR. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area. PUBLIC HEALTH RELEVANCE: Ultraviolet radiation exposure, especially when from artificial sources such as indoor tanning booths, contributes greatly to skin cancer, the most common form of human malignancy. The proposed study seeks to better understand the psychological and biological processes related to indoor tanning behavior among those at high risk for skin damage: young adult females. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area.

描述（由申请人提供）：作为最常见的人类恶性肿瘤，皮肤癌是一个主要的公共卫生问题。紫外线辐射 (UVR)，特别是室内日光浴室产生的紫外线，会显着增加患皮肤癌的风险。室内晒黑变得越来越普遍，尤其受到青少年和年轻成年女性的欢迎。虽然许多室内晒黑者出于外观原因进行晒黑，但经常晒黑的一小部分人可能会在心理和身体上依赖晒黑。有证据表明，紫外线照射会在体内产生物质（例如阿片类β-内啡肽），这些物质可能会增加积极的感觉和晒黑的欲望。该项目的主要目的是测试一种新颖的实验范式的可行性和可接受性，以研究可能激发持续室内晒黑行为的紫外线辐射的情感（情感）和生物决定因素以及对紫外线辐射的反应。将招募 18-25 岁的女性频繁和不频繁的室内日光浴者，并随机分配接受标准商业日光浴间的 UVR 和非 UVR（安慰剂）光，采用受试者内交叉设计。参与者将在紫外线照射前后完成心理访谈、问卷调查和血液样本采集。据推测，频繁和不频繁的室内晒黑者在心理/情感和生物标志物（ACTH、β-内啡肽）基线水平和对紫外线照射的反应以及遗传多态性（μ-阿片受体、 OPMR1）。我们的团队之前已经成功地对年轻人进行了几项皮肤癌预防和成瘾研究；因此，我们非常适合并具有独特的能力来开展拟议的项目。这种创新和转化工作对于理解晒黑欲望背后的心理和生物过程非常重要，特别是对于经常暴露在最大程度的有害紫外线照射下的室内晒黑者来说。更好地了解这些过程可能有助于制定更有效的预防工作，并有助于指导该领域的公共政策。 公共健康相关性：紫外线辐射暴露，尤其是来自室内日光浴室等人工来源的紫外线辐射，会极大地导致皮肤癌，这是人类最常见的恶性肿瘤。拟议的研究旨在更好地了解皮肤损伤高风险人群（年轻的成年女性）中与室内晒黑行为相关的心理和生物过程。更好地了解这些过程可能有助于制定更有效的预防工作，并有助于指导该领域的公共政策。