Multiscale Computational Modeling of Platelet Deposition and Coagulation in Flow

流动中血小板沉积和凝固的多尺度计算模型

基本信息

批准号：
8318577
负责人：
AARON L FOGELSON
金额：
$ 31.42万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-05 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8318577
关键词：
Affect Algorithms Area Binding Biochemical Reaction Biochemistry Biology Biomedical Engineering Biophysics Blood Blood Clot Blood Platelets Blood Vessels Blood coagulation Caliber Characteristics Chemicals Chemistry Coagulation Process Collaborations Communities Complex Computer Simulation Computer software Computing Methodologies Confocal Microscopy Data Deposition Development Education Engineering Enzymes Event Fibrin Foundations Future Gel Goals Grant Illinois Inflammation Institutes Instruction Investigation Lead Life Liquid substance Medical Medical Device Modeling Modification Myocardial Infarction Neoplasm Metastasis Performance Perfusion Physiological Process Reaction Research Research Personnel Science Scientist Simulate Societies Stroke Students Surface System Technology Thrombin Thrombosis Thrombus Time Validation Work arteriole atherogenesis chemical release computerized tools cost design empowered fibrous protein improved innovation model development novel parallel computing polymerization prevent research study simulation software development systems research tool venule

项目摘要

The long term goal of this project is to develop state of the art computational models of thrombosis in order to explore how physical and chemical factors interact to determine its progression. An integral component of the developmental work will be the experimental validation of the models using well-established perfusion systems and confocal microscopy for determining the characteristics of thrombus deposition. Specifically, 3D computational models of i) platelet mural thrombosis in small diameter blood vessels (arterioles), and ii) combined platelet thrombosis and coagulation in small vessels (arterioles and venules) will be developed. The models will be designed to take full advantage of high performance parallel computing capabilities as well as innovative mathematical and computational methods and will permit exploration of the complex, dynamic, and multiscale interplay between flow, chemistry and vascular biology in thrombosis. Through a Consortium arrangement with Dr. Vincent Turitto and his thrombosis group at the Illinois Institute of Technology, experiments will be conducted to provide the necessary experimental data. Modification of the models will occur through close interaction between the computational and experimental groups, and with the assistance of an Advisory Group of thrombosis experts. The project thus brings together a unique cross-disciplinary team of mathematicians, computational scientists, biomedical engineers and life scientists in a well integrated computational and experimental effort to understand intravascular thrombosis and to develop reliable models for predicting the course of thrombotic events that can help in designing improved medical devices and therapies to prevent and treat thrombosis.

该项目的长期目标是开发最先进的血栓形成计算模型，以探索物理和化学因素如何相互作用以确定其进展。开发工作的一个组成部分是使用完善的灌注系统和模型对模型进行实验验证。共聚焦显微镜用于确定血栓沉积的特征。具体来说，将开发 i) 小直径血管（小动脉）中血小板壁血栓形成和 ii）小血管（小动脉和小静脉）中血小板血栓形成和凝血相结合的 3D 计算模型。模型将被设计充分利用高性能并行计算能力以及创新的数学和计算方法，并将允许探索血栓形成中流动、化学和血管生物学之间复杂、动态和多尺度的相互作用。通过与 Vincent Turitto 博士的联盟安排他和他在伊利诺伊理工学院的血栓研究小组将进行实验，以提供必要的实验数据。模型的修改将通过计算组和实验组之间的密切互动以及血栓形成专家咨询小组的协助进行。因此，该项目汇集了一个由数学家、计算科学家、生物医学工程师和生命科学家组成的独特的跨学科团队，通过充分整合的计算和实验工作来了解血管内血栓形成并开发可靠的模型来预测血栓事件的进程，从而有助于设计改进的医疗设备和疗法来预防和治疗血栓形成。