Blood Pressure Control During Exercise in Heart Failure

心力衰竭运动期间的血压控制

• 批准号: 7822187
• 负责人: Donal S O'Leary
• 金额: $ 1.77万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7822187
• 关键词: Acute; Affect; American; Anesthesia procedures; Animal Model; Animals; Area; Arts; Baroreflex; Blood Circulation; Blood Pressure; Blood Vessels; Blood flow; Canis familiaris; Cardiac; Cardiac Output; Cardiovascular system; Catecholamines; Cause of Death; Chronic; Complex; Congestive Heart Failure; Conscious; Coronary; Diagnosis; Exercise; Exercise Tolerance; Face; Fatigue; Heart; Heart Rate; Heart failure; Hindlimb; Hormones; Human; Kidney; Laboratories; Mediating; Metabolic; Modeling; Moderate Exercise; Muscle; Normal Range; Operative Surgical Procedures; Plasma; Pump; Recovery; Reflex action; Reflex control; Relative (related person); Research Personnel; Rest; Role; Skeletal Muscle; Stroke Volume; Sympathetic Nervous System; Tachycardia; Testing; Trauma; United States National Institutes of Health; Vasodilation; Ventricular; Ventricular Dysfunction; Ventricular Function; blood pressure regulation; design; hemodynamics; instrument; instrumentation; muscle form; pressure; programs; research study; response; statistics; stem; vasoconstriction

DESCRIPTION (provided by applicant): A hallmark feature of ventricular dysfunction is decreased exercise tolerance. Even in normal subjects, dynamic exercise presents one of the greatest challenges to cardiovascular control. During strenuous dynamic exercise with a large muscle mass, cardiac output increases and vascular conductance to inactive areas decreases in order to provide both sufficient blood flow to active skeletal muscle and to maintain arterial blood pressure. In subjects with heart failure, these problems become exacerbated due to the limitations in ventricular function resulting in markedly altered cardiovascular responses to dynamic exercise. In this setting profound activation of the sympathetic nervous system often occurs as evidenced by high plasma catecholamines and intense vasoconstriction in inactive areas such as the splanchnic and renal vasculatures. Even active skeletal muscle may be relatively vasoconstricted. The mechanisms mediating these responses are poorly understood. 2 powerful reflexes exist which are capable of inducing the altered cardiovascular responses in subjects with heart failure: the muscle metaboreflex and the arterial baroreflex. Experiments described in this proposal are designed to test the functional importance of the muscle metaboreflex and the arterial baroreflex in mediating the altered cardiovascular responses to exercise in heart failure. Using our powerful conscious, chronically instrumented animal model, these studies are focused on determining the mechanisms of mediating these reflexes, the extent of interaction between these reflexes and how these mechanisms and interactions are altered in heart failure. Furthermore, we will explore the relationships between coronary blood flow and ventricular function during exercise in heart failure and whether recovery of normal cardiovascular control mechanisms can occur with the recovery from heart failure.

描述（由申请人提供）：心室功能障碍的标志性特征降低了运动耐受性。即使在正常受试者中，动态运动也列出了心血管控制面临的最大挑战之一。在剧烈的动态运动中，肌肉质量很大，心输出量增加和对无活性区域的血管电导量减少，以便提供足够的血液流动到活跃的骨骼肌并维持动脉血压。在心力衰竭的受试者中，由于心室功能的局限性导致心血管运动对动态运动的反应明显改变，因此这些问题变得恶化。在这种环境中，对交感神经系统的深刻激活通常发生在高血浆儿茶酚胺和诸如胚芽和肾脏血管等无活动区域的强烈血管收缩证明的情况下。即使是活跃的骨骼肌也可能是相对较血管收缩的。介导这些反应的机制知之甚少。存在2强反射，能够诱导心力衰竭受试者的心血管反应改变：肌肉代谢反射和动脉降压力反应。本提案中描述的实验旨在测试肌肉代谢反射和动脉压力反射的功能重要性，以介导心血衰竭运动的心血管反应改变。这些研究使用我们有力的有意识，长期仪器的动物模型，重点是确定介导这些反射的机制，这些反射之间的相互作用程度以及这些机制和相互作用如何改变心力衰竭。此外，我们将探索心力衰竭运动过程中冠状动脉血流与心室功能之间的关系，以及在心力衰竭中恢复正常的心血管控制机制是否会发生。