Reactome: An Open Knowledgebase of Human Pathways

Reactome：人类通路的开放知识库

• 批准号: 8306462
• 负责人: LINCOLN D. STEIN
• 金额: $ 85.85万
• 依托单位: ONTARIO INSTITUTE FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306462
• 关键词: Animal Model; Communities; Computer software; Data; Data Set; Data Sources; Databases; Gene Expression; Human; Human Genome; Lead; Molecular; Pathway interactions; Peer Review; Phase; Procedures; Proteins; Reaction; Research; data modeling; design; knowledge base; outreach; software systems; tool; user-friendly; web site

DESCRIPTION (provided by applicant): Accurate and complete human pathway information is crucial for the successful exploitation of the human genome in a variety of experimental contexts. The Reactome project has enjoyed a successful pilot phase to develop appropriate data models and tools for storing pathway information. In the pilot we have used these tools to curate to the highest level of accuracy pathways involving 1,200 non redundant proteins, which compares favourably to other pathway databases. In this proposal we aim to populate Reactome with pathways which comprise 5,000 non redundant human proteins and extend Reactome to incorporate an additional 10,000 proteins. Consistent with the pilot, all of Reactome's data and software will be made freely available.

描述（由申请人提供）：准确且完整的人类通路信息对于在各种实验环境中成功利用人类基因组至关重要。 Reactome 项目已经取得了成功的试点阶段，以开发适当的数据模型和工具来存储途径信息。在试点中，我们使用这些工具来管理涉及 1,200 个非冗余蛋白质的最高准确度的通路，这与其他通路数据库相比具有优势。在本提案中，我们的目标是用包含 5,000 个非冗余人类蛋白质的途径填充 Reactome，并扩展 Reactome 以纳入额外的 10,000 个蛋白质。与试点项目一致，Reactome 的所有数据和软件都将免费提供。