Case Center for Synchrotron Biosciences

同步加速器生物科学案例中心

• 批准号: 8337422
• 负责人: MARK R CHANCE
• 金额: $ 6.64万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337422
• 关键词: Accounting; Administrator; Advisory Committees; Bacteria; Binding; Biological Sciences; Biology; Biomedical Technology; Cell physiology; Communication; Communities; Complex; Conflict (Psychology); Coupled; Crystallography; Development; Disease; Drug Design; Educational workshop; Equipment; Funding; Goals; Grant; Individual; Institution; International; Leadership; Light; Mediating; Methods; Molecular; Monitor; National Institute of Biomedical Imaging and Bioengineering; Nucleic Acids; Office of Administrative Management; Organism; Output; Peer Review; Peer Review Grants; Productivity; Progress Reports; Proteins; Publications; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resource Allocation; Resources; Science; Services; Source; Spectrum Analysis; Strategic Planning; Structure; Synchrotrons; System; Techniques; Technology; Training; Training Programs; Training Support; United States National Institutes of Health; Universities; Virus; base; beamline; cost; detector; experience; in vivo; laboratory facility; lectures; medical schools; meetings; novel; operation; organizational structure; outreach; posters; programs; public health relevance; ranpirnase; research study; web site

DESCRIPTION (provided by applicant): The Case Center for Synchrotron Biosciences (CSB), with state-of-the-art facilities and laboratories at the National Synchrotron Light Source (NSLS) and at Case Western Reserve University School of Medicine (CWRU), is proposing to continue development and operation of a number of novel synchrotron beam lines to support an international clientele of users in the biomedical sciences. The resource currently serves over 550 users at the NSLS through the operation of four synchrotron beamlines that provide state-of-the art equipment, techniques, user support, and training for radiolytic footprinting, x-ray spectroscopy, and macromolecular crystallography experiments. The users come from across the US and from around the world. Three Technology Service Cores are proposed for the P30 Center. These include a footprinting core, based on the world-leading X28C footprinting beamline, which will provide protein, nucleic acid and in vivo footprinting facilities. An x-ray spectroscopy core, based on the X3B beamline, will receive a detector upgrade bringing its capabilities to state-of-the art in the US. The macromolecular crystallography core, particularly the X29 beamline, will expand its world-class productivity. Efficient mechanisms of delivering user service on our synchrotron beamlines will be continued and are contingent on effective training of users by our experienced beamline staff. The P30 proposes the support of 176 service projects across all three cores that are supported by 212 peer-reviewed grants, including 200 from the NIH. The Technology Service Core infrastructure is closely coupled to the needs of over one hundred user groups with peer-reviewed funding in a wide range of biological sciences. Based on specific developmental activities at the beamlines, user staff will enhance the research of the investigators that are presently using the resource's facilities. Pro-active programs of training and dissemination are outlined that will enhance the reach of the resource's programs and attract new users, expanding the research base. PUBLIC HEALTH RELEVANCE STATEMENT (provided by applicant): This project provides resources for the NIH funded scientific community to support the study of the structure and dynamics of macromolecuies. These studies are critical for understanding the normal biology of all organisms and the molecular effects of disease including the design of drugs to control cellular processes and the understanding of the molecular interactions that mediate the spread of viruses and bacteria.

描述（由申请人提供）：凯斯同步加速器生物科学中心 (CSB)，在国家同步加速器光源 (NSLS) 和凯斯西储大学医学院 (CWRU) 拥有最先进的设施和实验室，提议继续开发和运营许多新型同步加速器光束线，以支持生物医学领域的国际用户客户。该资源目前通过四个同步加速器光束线的运行为 NSLS 的 550 多个用户提供服务，这些同步加速器光束线提供最先进的设备、技术、用户支持以及放射分解足迹、X 射线光谱和大分子晶体学实验的培训。用户来自美国各地和世界各地。 P30中心拟设置三个技术服务核心。其中包括基于世界领先的 X28C 足迹光束线的足迹核心，它将提供蛋白质、核酸和体内足迹设施。基于 X3B 光束线的 X 射线光谱核心将获得探测器升级，使其功能达到美国最先进的水平。高分子晶体学核心，特别是 X29 光束线，将扩大其世界一流的生产力。在我们的同步加速器束线上提供用户服务的有效机制将继续下去，并且取决于我们经验丰富的束线员工对用户的有效培训。 P30 提议支持所有三个核心的 176 个服务项目，这些项目得到 212 项同行评审拨款的支持，其中 200 项来自 NIH。 技术服务核心基础设施与一百多个用户组的需求紧密结合，在广泛的生物科学领域拥有经过同行评审的资金。根据光束线的具体开发活动，用户工作人员将加强目前正在使用该资源设施的研究人员的研究。概述了积极主动的培训和传播计划，这将扩大资源计划的影响范围并吸引新用户，扩大研究基础。 公共卫生相关声明（由申请人提供）：该项目为 NIH 资助的科学界提供资源，以支持大分子结构和动力学的研究。这些研究对于了解所有生物体的正常生物学和疾病的分子效应至关重要，包括设计控制细胞过程的药物以及了解介导病毒和细菌传播的分子相互作用。