Anxiety Vulnerability and Smoking Cessation

焦虑脆弱性和戒烟

基本信息

批准号：
7665597
负责人：
Kirsten Johnson Langdon
金额：
$ 4.12万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7665597
关键词：
Abstinence Address Affect Affective Anxiety Anxiety Disorders Arts Attention Basic Science Behavioral Cigarette Smoker Clinical Cognitive Dependence Development Disease Emotions Fright Future Individual Differences Investigation Knowledge Lead Link Literature Maintenance Maps Mediating Methodology Modeling National Institute of Mental Health Nicotine Withdrawal Outcome Panic Pathway interactions Persons Pharmaceutical Preparations Play Populations at Risk Post-Traumatic Stress Disorders Prevalence Process Psyche structure Public Health Relapse Reporting Research Research Proposals Role Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Specific qualifier value Technology Testing Theoretical model Time Tobacco use Translating Withdrawal Symptom Work base cigarette smoking clinically significant coping depression experience indexing innovation neglect programs public health relevance smoking cessation success

项目摘要

DESCRIPTION (provided by applicant): The primary objectives of the current proposal are as follows: 1.a. To test the hypothesis that smokers characterized by higher compared to lower Anxiety Sensitivity (AS) will demonstrate less success in a self-guided cessation attempt, as indexed by: (1.a.1) Shorter time to first smoking lapse; (1.a.2) Lower point-prevalence abstinence at one, two, four, and 12 weeks post-quit date. 1.b. To test the hypothesis that the association between AS and lapse/relapse to smoking is mediated by the specified emotion and smoking-based processes, including: (1.b.1) Greater levels of negative affect intensity during the cessation attempt; (1.b.2) Greater levels of nicotine withdrawal symptom intensity during the cessation attempt. PUBLIC HEALTH RELEVANCE: The present proposal fills a needed clinically- and theoretically-relevant gap in the smoking- psychiatric literature, as recently espoused by the current NIMH smoking-psychiatric vulnerability report (Ziedonis et al., in press). Indeed, results of the proposed study will directly inform AS-smoking models, and serve more generally as an illustration of how specific anxiety-related processes serve to maintain smoking behavior. The proposed investigation represents a clinically significant and innovative test for a program of research aimed at understanding the mechanisms underlying smoking lapse and relapse.

描述（由申请人提供）：当前提案的主要目标如下： 1.a．为了检验以下假设：与较低焦虑敏感性 (AS) 相比，吸烟者在自我引导戒烟尝试中表现出的成功率较低，其索引如下： (1.a.1) 首次戒烟时间较短； (1.a.2) 戒烟后 1、2、4 和 12 周的戒烟流行率较低。 1.b.检验 AS 与戒烟/复吸之间的关联是由特定情绪和基于吸烟的过程介导的假设，包括： (1.b.1) 尝试戒烟期间负面情绪强度更高； (1.b.2) 尝试戒烟期间尼古丁戒断症状强度更高。公共健康相关性：本提案填补了吸烟精神病学文献中所需的临床和理论相关空白，正如最新的 NIMH 吸烟精神病学脆弱性报告（Ziedonis 等人，出版中）所支持的那样。事实上，这项研究的结果将直接为 AS 吸烟模型提供信息，并更广泛地说明特定的焦虑相关过程如何维持吸烟行为。拟议的调查代表了一项具有临床意义和创新性的测试，旨在了解戒烟和复吸的机制。