CityLab Promotes Understanding of Clinical Trials

CityLab 促进对临床试验的理解

基本信息

批准号：
7939709
负责人：
PETER R BERGETHON
金额：
$ 26.98万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7939709
关键词：
Academia Address Adopted Adult Award Biology Biotechnology Boston Cells Clinical Clinical Research Clinical Trials Code Communities Computer Analysis Computers Conduct Clinical Trials Data Data Analyses Development Education Education and Outreach Educational Curriculum Educational process of instructing Educational workshop Effectiveness Electrophoresis Elements Enrollment Ethical Issues Ethics Evaluation Exercise Fetal Hemoglobin Fostering Future Genes Goals Government Hand Health Policy Hemoglobin Human Individual Industry Informed Consent Internet Intervention Investigation Knowledge Laboratories Learning Life Life Style Link Location Manuals Medical Medical center Methods Mission Modeling Molecular Molecular Biology National Center for Research Resources Nature Parents Participant Patient Rights Patients Perception Phase Pilot Projects Point Mutation Process Public Health Reading Research Ethics Committees Research Personnel Resources Reticulocytes Rights Role Sampling School Teachers Schools Science Scientist Secondary Schools Secure Sickle Cell Anemia Simulate Students Testing Thinking Time Translating Translational Research United States National Institutes of Health Universities Visit Waiting Lists Work base career college computer generated data mining design drug candidate drug discovery drug efficacy experience health application high school human subject protection improved innovation insight interest knowledge base literacy medical schools member novel outreach post intervention programs public health relevance research study science education simulation sound success teacher university student

项目摘要

DESCRIPTION (provided by applicant): CityLab is a hands-on inquiry based biotechnology laboratory program that was organized in 1991 and has served more than 300,000 students and 3,000 teachers since that time. CityLab has two dedicated laboratories at Boston University School of Medicine and, with the development of its very successful mobile biotechnology laboratory (MobileLab), we now teach our curriculum supplements to approximately 7,000 middle and high school students per year. CityLab has become a successful model for both local and national efforts to improve pre-college science education. CityLab now seeks to expand its sphere of influence to teach students about clinical research. During this proposed Phase I/II project, we will develop a new curriculum supplement that includes both hands-on laboratory experiments and computer-generated simulations to impart a keen understanding and appreciation of the basic elements of clinical research to students in grades 9-12 and their teachers. To accomplish this, we will expand one of CityLab's most successful curriculum supplements entitled "The Mystery of The Crooked Cell". This supplement teaches students about the point mutation that is responsible for sickle cell anemia and it does so by engaging students to perform hemoglobin electrophoresis. To expand this curriculum supplement to teach students about clinical trials, students will learn about the importance of testing a novel drug candidate that may reverse the clinical manifestations of sickle cell disease by reactivating the gene that codes for the formation of fetal hemoglobin. Students will be introduced to several critical elements of the clinical trial process including the importance of translating bench science into the clinical arena. The clinical investigation phases (I, II, and III) will be explained through simulated investigations. In particular, students will design and analyze data from a simulated large clinical trial and students will "mine" the data to present their findings. Other important aspects of clinical trials such as the protection of patient rights, ethics, informed consent and IRBs will be included. The entire program will be expanded to include parents, teachers and the community at large. Our goal is to impart a deep appreciation of the importance of citizen participation in clinical trials and the importance of the data generated by a clinical trial. Since this original curriculum supplement has been widely adopted, the viability of this outreach model is well established. PUBLIC HEALTH RELEVANCE (provided by applicant): This project will bring together a team of high school teachers and students, scientists, and educators to develop an inquiry-based laboratory science curriculum supplement that integrates best practices from clinical trials outreach and education with sound science content and pedagogy. The curriculum supplement will explore sickle cell anemia from its molecular basis to a simulated clinical trial intervention. The materials will teach students, as well as their parents and members of their communities, essential biology content and will promote participation in clinical studies. The curriculum supplement will be evaluated in pilot studies in collaborating schools, leading to a final product that can be easily disseminated to all interested parties. Since few adults currently enroll in clinical trials, these materials may have a dramatic impact on public health by increasing the participation in these important studies.

描述（由申请人提供）：CityLab是一项基于动手查询的生物技术实验室计划，该计划于1991年组织，从那时起就为30万名学生和3,000名教师提供服务。 CityLab在波士顿大学医学院拥有两个专门的实验室，并且随着其非常成功的移动生物技术实验室（Mobilelab）的发展，我们现在每年向大约7,000名中学和高中生教授课程补充剂。 CityLab已成为当地和国家改善大学前科学教育的成功模型。 CityLab现在试图扩大其影响力领域，以教学学生有关临床研究的知识。在此拟议的I/II阶段项目中，我们将开发一种新的课程补充剂，其中包括动手实验室实验和计算机生成的模拟，以对9 - 12年级的学生敏锐地理解和欣赏临床研究的基本要素和他们的老师。为此，我们将扩大CityLab最成功的课程补充之一，标题为“弯曲的细胞的奥秘”。这种补充剂教会了学生有关镰状细胞贫血负责的点突变，并且通过吸引学生进行血红蛋白电泳来做到这一点。为了扩展这种课程补充剂以向学生传授临床试验，学生将了解测试一种新型药物候选者的重要性，该药物可能通过重新激活编码胎儿血红蛋白的基因来扭转镰状细胞疾病的临床表现。将向学生介绍临床试验过程的几个关键要素，包括将基准科学转化为临床领域的重要性。临床研究阶段（I，II和III）将通过模拟研究来解释。特别是，学生将设计和分析来自模拟的大型临床试验的数据，学生将“挖掘”数据以呈现他们的发现。还将包括临床试验的其他重要方面，例如保护患者权利，道德，知情同意和IRB。整个计划将扩展到包括父母，老师和整个社区。我们的目标是对公民参与临床试验的重要性以及临床试验产生的数据的重要性表示深刻的认识。由于这种原始的课程补充剂已被广泛采用，因此该外展模型的可行性已得到充分确立。公共卫生相关性（由申请人提供）：该项目将汇集一支由高中教师，学生，科学家和教育工作者组成的团队，以开发基于询问的实验室科学课程补充剂，该补品将临床试验的最佳实践与声音科学相结合内容和教学法。课程补充剂将探索镰状细胞贫血从其分子基础到模拟的临床试验干预措施。这些材料将教学生及其父母和社区成员，这是重要的生物学内容，并将促进参与临床研究。课程补充剂将在合作学校的试点研究中进行评估，从而导致最终产品可以轻松地传播给所有有关方面。由于目前很少有成年人参加临床试验，因此通过增加参与这些重要研究，这些材料可能会对公共卫生产生巨大影响。