Understanding the Neural Mechanisms Responsible for Tinnitus

了解导致耳鸣的神经机制

• 批准号: 7933795
• 负责人: Eric Daniel Young
• 金额: $ 26.85万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933795
• 关键词: Acoustic Nerve; Acoustic Trauma; Address; Affect; Animal Testing; Animals; Area; Auditory; Auditory system; Behavioral; Brain Part; CYP19A1 gene; Characteristics; Cochlea; Cochlear nucleus; DNA Sequence Rearrangement; Data; Data Set; Ear; Electrodes; Esthesia; Evaluation; Felis catus; Fiber; Figs - dietary; Fractals; Frequencies; Functional disorder; Funding; Goals; Hearing; Investigation; Maps; Measures; Methods; Minor; Nature; Nerve Fibers; Neurons; Outcome Study; Perception; Persons; Population; Production; Rattus; Severities; Site; Technology; Testing; Time; Tinnitus; Training; Trauma; Work; awake; base; behavior test; design; dorsal cochlear nucleus; hearing impairment; neuromechanism; public health relevance; relating to nervous system; research study; response; salicylate; sound; therapy design

DESCRIPTION (provided by applicant): This application addresses NIH's broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-DC-103* Understanding the Neural Mechanisms Responsible for Tinnitus. The proposed work investigates changes that occur in the auditory part of the brain after damage to the cochlea, particularly changes that may underlie the sensation of tinnitus or phantom sound. Animals will be given acoustic trauma over a range of severities from mild to moderate. We expect that this will produce animals with and without tinnitus, based on a behavioral test of the animals' phantom sound perception. We will record from neurons in a part of the brain that seems to be involved in tinnitus and characterize abnormalities in the electrical activity of its neurons, specifically abnormal spontaneous activity, spontaneous bursting activity, elevated randomness in their spontaneous discharge rates, and abnormal synchrony among neurons. The extent of various abnormalities will be related to the presence or absence of tinnitus to provide evidence for the specific abnormalities underlying tinnitus. Tinnitus is a condition affecting a large number of persons. Although it often accompanies hearing loss, it does not necessarily do so and may occur with little hearing impairment. The phantom sounds of tinnitus range from a minor annoyance to a debilitating problem. Attempts to ameliorate tinnitus are hampered by the lack of a clear idea of the nature of the underlying pathophysiology of tinnitus production. PUBLIC HEALTH RELEVANCE: The goal of this work is to identify the aspects of abnormal electrical activity of neurons that are most closely correlated with one form of tinnitus, which is tinnitus following acoustic trauma. The outcome of these studies is expected to aid in designing interventions to reduce tinnitus.

描述（由申请人提供）：此申请介绍NIH的广泛挑战领域（06）启用技术和特定挑战主题，06-DC-103*了解负责耳鸣的神经机制。拟议的工作调查了对耳蜗损害后大脑听觉部分发生的变化，尤其是可能是耳鸣或幻影声音的构成的变化。在轻度到中度的一系列严重程度上，将给动物造成声学创伤。我们预计，基于对动物幻影的声音感知的行为测试，这将产生带有或不具有耳鸣的动物。我们将从大脑的一部分中记录似乎参与耳鸣的一部分，并表征其神经元的电活动异常，特别是异常的自发活动，自发性爆发活性，自发放电的随机性升高以及自发性放电的随机性升高，并且异常同步神经元。各种异常的程度将与耳鸣的存在或不存在有关，以提供耳鸣基于的特定异常的证据。耳鸣是影响大量人的条件。尽管它通常伴随着听力损失，但它不一定会伴随着，并且可能在听力障碍的情况下发生。耳鸣的幻影声音从轻微的烦恼到令人衰弱的问题。由于缺乏对耳鸣生产的基本病理生物生物生物生物生物的本质的明确观念，试图改善耳鸣的尝试受到了阻碍。 公共卫生相关性：这项工作的目的是确定神经元异常的电活动的各个方面，这些神经元与一种形式的耳鸣密切相关，这是声学创伤后的耳鸣。这些研究的结果有望有助于设计干预措施以减少耳鸣。