NANOTECHNOLOGY FOR CANCER DETECTION AND THERAPEUTICS

用于癌症检测和治疗的纳米技术

• 批准号: 7960175
• 负责人: BALAJI PANCHEPAKESAN
• 金额: $ 5.46万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960175
• 关键词: Blood; Breast; Cancer Detection; Carbon; Cell Culture Techniques; Chickens; Computer Retrieval of Information on Scientific Projects Database; Delaware; Devices; Embryo; Funding; Grant; IGF1R gene; Institution; Malignant neoplasm of pancreas; Modeling; Molecular; Monitor; Nanotechnology; Nanotubes; Normal Cell; Research; Research Personnel; Resources; Source; Structure; Surface; System; Techniques; Therapeutic; Toxic effect; United States National Institutes of Health; base; cancer cell; overexpression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Balaji Panchapakesan Nanotechnology for Cancer Detection and Therapeutics The objectives of this project are to develop nanotechnology based cancer detection systems by monitoring molecular overexpressions in cancer cells using carbon nanotube devices. Another objective of this project is to use nanotechnology based techniques to destroy cancer cells selectively with out harming normal cells. Nanotechnology encompasses the creation and utilization of materials, devices and systems at the level of atoms, molecules and supramolecular structures. By using the high sensitivity of nanotubes to localized surface interactions with biomolecules, it is possible for us to detect molecular overexpressions in cancer cells. The overexpressions of IGF1R and Her2 in breast and pancreatic cancer cells have been demonstrated with high sensitivity in cell cultures. Similarly, nanotubes have been used as nanobombs for selective targeting of cancer cells in cell cultures. The next steps are to detect the sense molecular overexpressions in cancer cells in blood and also to start evaluating the toxicity of nanotubes in chicken embryo model.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Balaji Panchapakesan 癌症检测和治疗剂的纳米技术 该项目的目标是通过使用碳纳米管设备监测癌细胞中的分子过表达来开发基于纳米技术的癌症检测系统。该项目的另一个目的是使用基于纳米技术的技术来选择性地破坏癌细胞，从而损害正常细胞。纳米技术涵盖了原子，分子和超分子结构水平的材料，设备和系统的创建和利用。通过使用纳米管对与生物分子的局部表面相互作用的高灵敏度，我们可以检测到癌细胞中的分子过表达。乳腺癌和胰腺癌细胞中IGF1R和HER2的过表达已在细胞培养物中具有高灵敏度。同样，纳米管已被用作纳米肉瘤，用于选择性靶向细胞培养物中的癌细胞。接下来的步骤是检测血液中癌细胞中的感觉分子过表达，并开始评估鸡肉胚胎模型中纳米管的毒性。