BIOINFORMATICS/MICROARRAY SATELLITE CORE-OSU

生物信息学/微阵列卫星核心-OSU

• 批准号: 7960008
• 负责人: ULRICH K MELCHER
• 金额: $ 10.84万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960008
• 关键词: Administrator; Amblyomma; Bioinformatics; Biomedical Research; Bos taurus; Bread; Campylobacter jejuni; Cattle; Chinese Hamster Ovary Cell; Client; Computer Analysis; Computer Retrieval of Information on Scientific Projects Database; Consultations; Core Facility; Cricetus; Cynodon; Data; Educational workshop; Emericella nidulans; Faculty; Feedback; Funding; Gossypium; Grant; Homo sapiens; House mice; Human Resources; Institution; Journals; Label; Laboratories; Lycopersicon esculentum; Medicago truncatula; Microbe; Nucleic Acids; Oklahoma; Oligonucleotide Microarrays; Organism; Peer Review; Polynucleotides; Positioning Attribute; Preparation; Principal Investigator; Publications; Rattus; Rattus norvegicus; Research; Research Personnel; Research Support; Resources; Scanning; Scientist; Services; Sorghum; Source; Specialist; Spottings; Students; Synechocystis; System; Ticks; Time; Tomatoes; Training; Training and Education; Triticum aestivum; United States National Institutes of Health; Universities; Wheat; Work; experience; functional genomics; improved; influenzavirus; instrument

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Oklahoma State University (OSU) Microarray Core Facility (OMCF) and its associated bioinformatics group, BioinfOSU, provide facilities, consultation, education and training. Their facilities include modern instruments for the preparation of microarrays of oligo- and polynucleotides, for their hybridization to labeled target nucleic acids, for scanning the fluorescent intensities of spots after hybridization and for computational analysis of the results. Staff includes a Ph. D. faculty-level microarray specialist with extensive bioinformatics experience, an applications programmer versed in microarray data handling and a systems administrator. All personnel positions have been transitioned to permanent full-time positions insuring the continued support of research at Oklahoma State University and beyond. To demonstrate that such staff and facilities stimulate and facilitate research in functional genomics, OMCF and BioinfOSU provide workshops and consultation services to investigators of all levels, as well as making their resources generally available. Groups led by more than 25 Principal Investigators use OSU microarray and bioinformatics facilities to study a diverse range of organisms: Amblyomma americanum (lone star tick), Campylobacter jejuni, Cynodon dactylon (bermuda grass), Emericella nidulans, Gossypium hirsutum (cotton), Influenza viruses, Lycopersicon esculentum (tomato), Rattus norvegicus (rat), Sorghum, Synechocystis sp. PCC6803, Triticum aestivum (bread wheat), Medicago truncatula, Mus musculus, Homo sapiens, Dunaliella spp., Aspergillis nidulans, Cricetus (Chinese hamster ovary cells), Bos taurus (cow), and various pathogenic microbes. The work supported by the facility has led to publications in peer-reviewed journals (see section G). In addition to training graduate and postdoctoral students, the scientists leading these laboratories annually welcome numerous undergraduate students into their laboratories to participate in the research. Feedback from clients continually improves the ability of the facilities to provide services and advice.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 俄克拉荷马州立大学 (OSU) 微阵列核心设施 (OMCF) 及其相关生物信息学小组 BioinfOSU 提供设施、咨询、教育和培训。 他们的设施包括用于制备寡核苷酸和多核苷酸微阵列、用于与标记的靶核酸杂交、用于扫描杂交后斑点的荧光强度以及用于结果的计算分析的现代仪器。 工作人员包括一名具有丰富生物信息学经验的博士级微阵列专家、一名精通微阵列数据处理的应用程序员和一名系统管理员。 所有人员职位均已转变为永久性全职职位，以确保俄克拉荷马州立大学及其他地区的研究得到持续支持。为了证明这些人员和设施能够刺激和促进功能基因组学的研究，OMCF 和 BioinfOSU 为各级研究人员提供研讨会和咨询服务，并普遍提供其资源。 由超过 25 名主要研究人员领导的小组使用 OSU 微阵列和生物信息学设施来研究多种生物体：Amblyomma americanum（孤星蜱）、空肠弯曲杆菌、Cynodon dactylon（百慕大草）、Emericella nidulans、Gossypium hirsutum（棉花）、流感病毒、Lycopersicon esculentum（番茄）、褐家鼠（大鼠）、高粱、集胞藻属 sp。 PCC6803、普通小麦（面包小麦）、蒺藜苜蓿、小家鼠、智人、杜氏藻、构巢曲霉、仓鼠（中国仓鼠卵巢细胞）、牛（牛）和各种病原微生物。 该机构支持的工作已在同行评审期刊上发表文章（见 G 部分）。除了培养研究生和博士后外，领导这些实验室的科学家每年都会欢迎众多本科生进入他们的实验室参与研究。 客户的反馈不断提高设施提供服务和建议的能力。