The neural basis of social cognition

社会认知的神经基础

基本信息

批准号：
7761230
负责人：
Aina Puce
金额：
$ 30.52万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-03 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7761230
关键词：
Action Potentials Amygdaloid structure Area Asperger Syndrome Attention Auditory Autistic Disorder Bilateral Binding Biological Brain Cell physiology Cephalic Cognitive Communication Communication impairment Cues Data Data Collection Data Set Development Disease Electrophysiology (science)Elements Emotional Event-Related Potentials Exhibits Face Facial Expression Functional Magnetic Resonance Imaging Future Gestures Goals Human Impairment Investigation Knowledge Life Link Literature Macaca Macaca mulatta Magnetic Resonance Imaging Measurement Measures Methods Mind Modality Modeling Monkeys Motion Movement Neurons Oral cavity Persons Physiological Pongidae Population Population Process Primates Procedures Process Reading Relative (related person)Research Research Personnel Resolution Scalp structure Schizophrenia Signal Transduction Sneezing Social Environment Source Stimulus Structure Structure of superior temporal sulcus Study Subject Techniques Time Translating Visual Work base cognitive neuroscience experience frontal lobe gaze indexing innovation mental state millimeter millisecond multisensory neocortical neural model neuroimaging neuromechanism neurophysiology nonhuman primate programs relating to nervous system response skills social social cognition social communication theories vocalization

项目摘要

The research program in this application is concerned with the neural basis of social cognition. We propose to examine neocortical areas in and near the superior temporal sulcus (SIS), a region known for its ability to process the motion of living forms, integrate information from different sense modalities, and respond to agency and perspective taking. The STS region together with the amygdala, several parts of the frontal lobe, and other brain areas are thought to form a brain network dealing with social cognition. We propose to study the neural mechanisms of basic social cognition in humans and macaques by recording unisensory and multisensory responses elicited to social and non-social stimuli. We will study cross-species neural responses to visual, auditory and combined audiovisual stimulation. Apparent motion activation tasks depicting combined facial expressions and associated non-verbal vocalizations will be studied. We will use identical activation tasks to collect neurophysiological and neuroimaging data in human and macaque subjects. Event-related potential (ERP) recordings provide information with excellent time resolution - to millisecond precision, whereas neuroimaging techniques, such asfunctional magnetic resonance imaging (fMRI), provide accurate spatial information -to millimeter resolution. Combined fMRI and ERP measures in humans will provide an accurate picture of the brain circuits and temporal dynamics of social cognition. Under the identical experimental conditions, combined ERP and action potential recordings in macaques will identify the neuron populations and cellular processes indexed by the ERP measurements. Understanding how the healthy primate brain processes social information is important to understanding the biological bases for the social communication disorders (e.g. Asperger's syndrome, autism, schizophrenia), where severe impairments occur in reading social information from others. By using the same activation tasks and comparable methods in humans and monkeys we will be able to determine important similarities as well as differences in how the brain deals with relevant social information. Further, our multi-technique approach within each species will allow us to visualize where and when the brain activation manifests in the monkey and human brain.

该应用程序的研究计划涉及社会认知的神经基础。我们建议检查颞上沟（SIS）及其附近的新皮质区域，该区域以其处理生命形式的运动、整合来自不同感官模式的信息的能力，以及回应代理和观点采择。 STS 区域与杏仁核、大脑的几个部分一起额叶和其他大脑区域被认为形成了处理社会认知的大脑网络。我们建议通过以下方式研究人类和猕猴基本社会认知的神经机制记录对社会和非社会刺激引起的单感觉和多感觉反应。我们将学习对视觉、听觉和组合视听刺激的跨物种神经反应。表观运动描述组合面部表情和相关非语言发声的激活任务将是研究过。我们将使用相同的激活任务来收集人类的神经生理学和神经影像数据和猕猴科目。事件相关电位 (ERP) 记录提供出色的时间信息分辨率 - 精确到毫秒，而神经影像技术，例如功能磁共振成像 (fMRI)，提供精确到毫米分辨率的空间信息。联合功能磁共振成像人类的 ERP 测量将提供大脑回路和时间动态的准确图像社会认知。在相同的实验条件下，结合 ERP 和动作电位记录猕猴将识别由 ERP 测量索引的神经元群体和细胞过程。了解健康的灵长类动物大脑如何处理社会信息对于理解社交沟通障碍（例如阿斯伯格综合症、自闭症、精神分裂症），在阅读他人的社交信息时会出现严重障碍。通过使用我们将能够确定人类和猴子的相同激活任务和类似方法大脑如何处理相关社会信息的重要相似之处和差异。更远，我们对每个物种的多种技术方法将使我们能够想象大脑在何时何地激活表现在猴子和人脑中。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural correlates of apparent motion perception of impoverished facial stimuli: a comparison of ERP and ERSP activity.

DOI：
10.1016/j.neuroimage.2014.04.029
发表时间：
2014-09
期刊：
NeuroImage
影响因子：
5.7
作者：
Rossi A;Parada FJ;Kolchinsky A;Puce A
通讯作者：
Puce A

Audiovisual non-verbal dynamic faces elicit converging fMRI and ERP responses.

DOI：
10.1007/s10548-009-0093-6
发表时间：
2009-05
期刊：
BRAIN TOPOGRAPHY
影响因子：
2.7
作者：
Brefczynski-Lewis, Julie;Lowitszch, Svenja;Parsons, Michael;Lemieux, Susan;Puce, Aina
通讯作者：
Puce, Aina

Multiple faces elicit augmented neural activity.