Immunology

免疫学

• 批准号: 7944864
• 负责人: YOJI SHIMIZU
• 金额: $ 2.61万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-08 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944864
• 关键词: Address; Antigens; Arts; Basic Science; Biological Models; Budgets; Cancer Center; Cancer Center Support Grant; Collaborations; Coupled; Development; Doctor of Philosophy; Evaluation; Faculty; Foundations; Funding; Goals; Group Meetings; Imagery; Immune response; Immune system; Immunology; Immunotherapeutic agent; Immunotherapy; Institutes; Lead; Lymphocyte; Lymphocyte Activation; Malignant Neoplasms; Minnesota; Molecular Immunology; Mus; Peer Review; Peripheral; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Research Technics; Schools; Seminal; Signal Transduction; Technology; Testing; Translating; Translational Research; Universities; Veterinary Medicine; abstracting; cancer immunotherapy; college; design; in vivo; insight; interest; medical schools; member; novel; programs; tumor immunology

8.5.1 ABSTRACT: IMMUNOLOGY The Immunology program, lead by Yoji Shimizu, Ph.D., has 16 members, representing seven departments and three schools. As of September 30,2007, these members have a total of $8.1 million in peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 163 publications, of which 15% were intra-programmatic and 28% were inter-programmatic. The scientific goals of the program are to elucidate the basic mechanisms that underlie the development and function of the immune system, and to use this information to enhance the evaluation, development and implementation of effective anti-cancer immunotherapies. Research activities in the program are focused on four research themes: mechanisms, of lymphocyte tolerance, lymphocyte activation and signal transduction, lymphocyte development, and tumor immunology/immunotherapy. Significant strength in cellular and molecular immunology has allowed Immunology program investigators to develop novel technical approaches for the analysis and quantitation of the immune response in vivo that have led to seminal insights into the development and function of the adaptive immune response. Intra-programmatic collaborations are facilitated by regular group meetings, common research space for program investigators, and a NIH-funded program project on peripheral tolerance. Intra-programmatic and inter-programmatic collaborations, coupled with new faculty recruitment, have enhanced translational research activities within the program. These activities have allowed program investigators to utilize basic research insights obtained within the program as a foundation for the development and testing of specific immunotherapeutic approaches designed to enhance the immune response to cancer.

8.5.1摘要：免疫学 由Yoji Shimizu博士领导的免疫学计划有16名成员，代表七个部门 和三所学校。截至2007年9月30日，这些成员共有810万美元的同行评审， 在当前预算期间资助了研究项目。自2003年6月以来，他们的研究已导致163 出版物，其中15％是截面性的，有28％是截面间截面的。科学目标 该计划的内容是阐明基本机制的基本机制 免疫系统，并使用此信息来增强评估，开发和实施 有效的抗癌免疫疗法。该计划中的研究活动集中于四项研究 主题：淋巴细胞耐受性，淋巴细胞激活和信号转导的机制，淋巴细胞 发育和肿瘤免疫学/免疫疗法。细胞和分子的显着强度 免疫学允许免疫学计划调查人员开发新的技术方法 对体内免疫反应的分析和定量，导致了对该体内的开创性见解 自适应免疫反应的发展和功能。主要的合作协作是 由常规小组会议，计划调查员的共同研究空间和NIH资助的促进 外围耐受性的计划项目。截面和程序间合作，耦合 随着新的教师招聘，该计划中的翻译研究活动增强了。这些 活动使计划调查人员能够利用该计划中获得的基础研究见解 作为开发和测试特定免疫治疗方法的基础 增强对癌症的免疫反应。