STRUCTURAL MAPPING OF CD134 BINDING RECEPTOR FOR BINDING OF FIV

用于结合 FIV 的 CD134 结合受体的结构作图

• 批准号: 7955255
• 负责人: John H Elder
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955255
• 关键词: Binding; Biomedical Computing; CD4 Positive T Lymphocytes; CXCR4 gene; Computer Retrieval of Information on Scientific Projects Database; Family Felidae; Feline Immunodeficiency Virus; Funding; Grant; Human; Infection; Institution; Maps; Research; Research Personnel; Resources; Source; Specificity; United States National Institutes of Health; Virus; Virus Diseases; receptor binding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4+ T cells. Human CD134 fails to support FIV infection. To delineate the regions important for defining virus specificity of CD134, we exchanged domains between human and feline CD134.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 CD134 是猫免疫缺陷病毒 (FIV) 的主要结合受体，与 CXCR4 一起促进 CD4+ T 的感染 细胞。人类 CD134 不支持 FIV 感染。描绘对于定义病毒特异性重要的区域 CD134，我们在人类和猫科动物 CD134 之间交换了域。