SPIROMICS Radiology Center

SPIROMICS 放射中心

• 批准号: 7806793
• 负责人: ERIC HOFFMAN
• 金额: $ 17.32万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7806793
• 关键词: SPIROMICS; Radiology; Center

SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) contractors will design and conduct a clinical research study with extensive subject phenotyping and molecular fingerprinting to identify subpopulations of patients with chronic obstructive pulmonary disease (COPD) and to identify and validate surrogate markers of disease severity which will be useful as intermediate outcome measures for clinical trials. Research subjects will be enrolled, phenotyped, and followed at approximately six Clinical Centers (CCs). A Genomics and Informatics Center (GIC) will have primary responsibility for developing a scientific plan for achieving study aims; analyzing phenotypic and high-throughput molecular data; operating a repository of biospecimens; developing bioinformatic resources; data management; providing overall management and oversight of the study; and disseminating study results. The Radiology Center will have primary responsibility for standardizing imaging methods at the Clinical Centers; establishing a repository of CT image data; assessing and assuring quality of CT images; and analyzing CT images to obtain quantitative measures that may indicate the presence and/or severity of COPD or other lung diseases.

COPD研究（Supomics）承包商中的亚群和中级结果度量将设计和进行一项临床研究，具有广泛的受试者表型和分子指纹识别，以鉴定慢性阻塞性肺疾病（COPD）患者的亚群，并识别和验证疾病的疾病替代标记，以便在疾病中进行疾病的替代标记，以便在临床上进行临时试验。 研究对象将在大约六个临床中心（CCS）招收，表现并遵循。 基因组学和信息学中心（GIC）将对制定科学计划来实现研究目标；分析表型和高通量分子数据；经营生物测量的存储库；开发生物信息学资源；数据管理；提供整体管理和研究；并传播研究结果。 放射学中心将在临床中心标准化成像方法的主要责任；建立CT图像数据的存储库；评估和确保CT图像的质量；并分析CT图像以获得可能表明COPD或其他肺部疾病的存在和/或严重程度的定量度量。