SPORE in Head and Neck Cancer

头颈癌中的孢子

• 批准号: 7926141
• 负责人: DONG M SHIN
• 金额: $ 20万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-23 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926141
• 关键词: Apoptosis; Biological Markers; Biology; Biostatistics Core; Cessation of life; Chemoprevention; Clinical Research; Clinical Sciences; Clinical Trials; Curcumin; Development; Disease; Funding; Goals; Green tea; Head and Neck Cancer; Health Sciences; Institutes; Institution; Malignant Neoplasms; Mediating; Morbidity - disease rate; Nanotechnology; Outcome; Paclitaxel; Pathology; Patients; Phase; Phase I Clinical Trials; Polyphenon E; Prevention; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Specialized Program of Research Excellence; Specimen; Testing; Translational Research; Translations; Universities; Work; analog; career; career development; data management; disability; head and neck cancer patient; improved; interdisciplinary approach; medical schools; meetings; nanoparticle; novel; novel therapeutic intervention; programs; receptor

DESCRIPTION (provided by applicant): The Emory University Winship Cancer Institute (Emory WCI) proposes to conduct a Specialized Program of Research Excellence (SPORE) for Head and Neck Cancer (HNC). The overall goal of the Emory WCI HNC SPORE is to improve prevention and treatment of head and neck cancer with emphasis on new discoveries, rapid translation to patients who are suffering, disability and morbidity caused by this disease. The SPORE program will consist of four (4) major translational research projects, two research cores, an administrative core, a developmental research program, and a career development program. The WCI HNC SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with coinvestigators in basic, translational, and clinical science. All projects will test hypotheses about biology, prevention, molecularly and nanotechnology driven novel therapeutic approaches. The four (4) main projects are: (1) Chemoprevention with Green Tea Polyphenon E and EGFR-TKIs in HNC; (2) Targeting Death Receptors-Mediated Apoptosis for HNC; (3) Development of Novel Curcumin Analogs for the Treatment of Head and Neck Cancer, (4) Biodegradable Nanoparticle Formulated Taxol for Targeted Therapy of HNC. Each project in our SPORE program is centered on clearly defined translational objectives including pilot clinical trials (project 1, Phase I Study of Chemoprevention; project 2, biomarker studies; project 3, phase 0 trial of EF24; project 4, phase 1b clinical study) that have close interaction with the cores. The two research cores (Specimen Resources and Pathology Core, Biostatistics and Data Management Core) will assist the main research projects, developmental research projects, and career developmental investigators in performing head and neck cancer translational research. The Administrative Core will provide scientific and financial oversight for the SPORE program. We also have a strong commitment of support including space, recruitment, shared resources and matching funds from the Emory Winship Cancer Institute, Emory University School of Medicine, Woodruff Health Science Center at Emory University, Georgia Cancer Coalition (GCC), and the Georgia Research Alliance (GRA). The Emory WCI HNC SPORE investigators will work closely together as a team to achieve the goals of the program and will also interact with investigators from HNC SPORES at other institutions and other research programs to improve outcomes for head and neck cancer patients.

描述（由申请人提供）：埃默里大学Winship Cancer Institute（Emory WCI）建议针对头颈癌（HNC）进行专业的研究卓越研究计划（SPORE）。 Emory WCI HNC孢子的总体目标是改善对头颈癌的预防和治疗，重点是新发现，快速转化为遭受这种疾病引起的苦难，残疾和发病率的患者。孢子计划将包括四（4）个主要的转化研究项目，两个研究核心，一个行政核心，一个发展研究计划和职业发展计划。 WCI HNC孢子将使用跨学科的方法来实现其目标，通过与基本，转化和临床科学领域的共同评估者进行项目。所有项目都将检验有关生物学，预防，分子和纳米技术驱动的新型治疗方法的假设。四（4）个主要项目是：（1）HNC中使用绿茶Polyphenon E和EGFR-TKI的化学预防； （2）针对HNC的死亡受体介导的凋亡； （3）开发用于治疗头颈癌的新型姜黄素类似物，（4）可生物降解的纳米颗粒配制的紫杉醇用于HNC的靶向治疗。我们的孢子计划中的每个项目都集中在明确定义的翻译目标上，包括试验临床试验（项目1，化学预防I阶段研究；项目2，生物标志物研究；项目3，EF24阶段第0阶段试验；项目4阶段4，第1阶段1B临床研究），与核心密切相互作用。这两个研究核心（标本资源和病理核心，生物统计学和数据管理核心）将帮助主要的研究项目，发展研究项目和职业发展研究人员进行头颈癌转化研究。行政核心将为孢子计划提供科学和财务监督。我们还拥有坚定的支持承诺，包括来自埃默里·温船癌症研究所，埃默里大学医学院，埃默里大学伍德拉夫健康科学中心，乔治亚癌症联盟（GCC）和乔治亚研究联盟（GRA）的太空，招聘，共享资源和匹配资金。 Emory WCI HNC孢子研究人员将作为一个团队紧密合作，以实现该计划的目标，并将与其他机构和其他研究计划的HNC孢子的研究人员进行互动，以改善针对头颈癌患者的结果。