Chicago Tri-Institutional Center for Chemical Methods and Library Development

芝加哥三机构化学方法和图书馆开发中心

• 批准号: 7868750
• 负责人: SERGEY A KOZMIN
• 金额: $ 21.87万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7868750
• 关键词: Address; Amphotericin B; Area; Arts; Award; Biological; Biological Factors; Biology; Catalysis; Cells; Chemicals; Chemistry; Chicago; Communicable Diseases; Communities; Complex; Core Facility; Development; Engineering; Equipment; Erythromycin; Exposure to; Funding; General Population; Generations; Genomics; Goals; Gold; Illinois; Immobilization; Immunology; Individual; Institutes; Institution; Internships; Laboratories; Letters; Libraries; Link; Medicine; Methods; Mission; Molecular Bank; Monitor; Nitrogen; Operative Surgical Procedures; Organic Synthesis; Palladium; Pharmaceutical Preparations; Physical condensation; Probability; Problem Solving; Process; Production; Qualifying; Reaction; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Development; Resources; Scientist; Screening procedure; Series; Sirolimus; Students; Surface; Systems Biology; Therapeutic; Training; Translating; Translations; United States National Institutes of Health; Universities; Work; base; cheminformatics; cycloaddition; design; graduate student; high throughput analysis; high throughput screening; innovation; interest; lectures; meetings; miniaturize; monolayer; next generation; oncology; outreach; programs; research facility; scaffold; skills; small molecule; small molecule libraries; success

DESCRIPTION (provided by applicant): The main objective of our application to NIH is to establish the Chicago Tri-lnstitutional Center for Chemical Methods and Library Development (CTCMLD), which is designed to address the fundamental challenges of high-throughput organic synthesis and to provide major advances that will significantly facilitate the development of small-molecule libraries for broad biological screening. Our CTCMLD application is strongly supported by the three participating institutions and the Chicago Biomedical Consortium, which provided a $2 Million Lever Award to match the NIH funding. The CTCMLD will have several major goals listed below. Center Objective 1: Conduct four highly integrated projects that are designed to significantly facilitate the generation of chemical diversity and assembly of high-quality small-molecule libraries. The four proposed projects are: (a) practical synthesis of new nitrogen-based heterocyclic libraries (leaders: Scheldt and Gevorgyan); (b) multi-component assembly of polyketide libraries (leader: Yamamoto); (c) assembly of scaffold-unbiased small-molecule libraries (leader: Kozmin); and (d) development of tailored surfaces for new reaction development, miniaturized library synthesis and small-molecule immobilization (leader: Mrksich). The scientific projects will be carried out at the highest level, resulting in the development of an arsenal of new synthetic methods, which in turn will enable the generation of approximately 20,000 new compounds of 20 mg scale in highly efficient, parallel manner. Center Objective 2: Training the next generation of scientists, who will develop and arsenal of new methods and strategies for high-throughput organic synthesis. Center Objective 3: Establish core research facility for library synthesis, characterization and cheminformatics. The Core facility will have three highly integrated components: High-Throughput Synthesis Component located at the University of Chicago, Hit-to-Lead Development Resource located on Northwestern campus and Cheminformatics Core at the University of Illinois at Chicago. Objective 4: Provide broad outreach to the biology community enabling rapid and efficient screening of new compound libraries. In addition to providing new compounds for the NIH Roadmap Molecular Libraries Initiative, we will collaborate with three major high-throughput screening centers in Illinois, and many individual biology laboratories. The increased connectivity and synergy resulting from the work of the CTCMLD will represent a major advance in the Chicago area's capabilities and a paradigm shift in how the Chicago academic community will approach and solve problems at the interface of chemistry, biology and medicine.

描述（由申请人提供）：我们向NIH申请的主要目的是建立芝加哥三机构化学方法与图书馆发展中心（CTCMLD），该中心旨在应对高通量有机合成的基本挑战，并提供重大进步，这将显着促进小型核心图书馆的开发。我们的CTCMLD申请得到了三个参与机构和芝加哥生物医学财团的强烈支持，该财团提供了200万美元的杠杆奖，以符合NIH的资金。 CTCMLD将在下面列出几个主要目标。中心目标1：进行四个高度集成的项目，这些项目旨在显着促进化学多样性的产生和高质量小分子库的组装。提出的四个项目是：（a）新的基于氮的杂环库（领导者：Scheldt和Gevorgyan）的实际合成； （b）聚酮化合物库的多组分组装（领导者：山本托多）； （c）组装脚手架的小分子库（领导者：科兹明）； （d）开发量身定制的表面，以进行新的反应发展，微型图书馆合成和小分子固定化（负责人：MRKSICH）。科学项目将在最高级别进行，从而开发出新的合成方法的库，这反过来又可以以高效的平行方式生成约20,000种20毫克尺度的新化合物。中心目标2：培训下一代科学家，他们将开发和武器库的高通量有机合成的新方法和策略。中心目标3：建立用于图书馆合成，表征和化学信息学的核心研究设施。核心设施将具有三个高度集成的组件：位于芝加哥大学的高通量合成组件，位于西北校园的热门发展发展资源和伊利诺伊大学芝加哥大学的化学形象核心。目标4：为生物学社区提供广泛的宣传，从而可以快速有效地筛选新的复合库。除了为NIH路线图分子图书馆计划提供新化合物外，我们还将与伊利诺伊州的三个主要高通量筛查中心和许多个人生物学实验室合作。 CTCMLD工作所产生的连接性和协同作用提高将代表芝加哥地区能力的重大进步，以及芝加哥学术界将如何在化学，生物学和医学界面上解决和解决问题的范式转变。