CHEMOSENSORY CLINICAL RESEARCH CENTER

化学传感临床研究中心

• 批准号: 7849878
• 负责人: GARY K BEAUCHAMP
• 金额: $ 65.93万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849878
• 关键词: CHEMOSENSORY; CLINICAL; RESEARCH; CENTER

DESCRIPTION (provided by applicant): Funds are requested to support new projects in the Monell-Jefferson Chemosensory Clinical Research Center CCRC). This CCRC involves a collaboration between scientists at the Monell Chemical Senses Center and physicians at Thomas Jefferson University. Collaborative ties also exist with physicians and scientists at the University of Pennsylvania, several other Universities, and the Veterans Affairs Medical Center of Philadelphia. It is devoted to the scientific examination of clinical disorders in taste, smell and chemical irritation. Through the multidisciplinary study of clinical populations, the goals of CCRC scientists are to characterize and understand the etiologies of disorders in chemosensory function, provide information on mechanisms and functions of the chemical senses in humans, and develop strategies for treating/coping with chemosensory disorders. The CCRC entails an Administrative Core unit, a Sensory/Medical Core unit and three individual yet highly interrelated research Projects. The general aims of each of the three Projects, respectively, are to: 1) Evaluate the causal factors underlying smell loss in patients with chronic rhinosinusitus, such as alterations of air flow and odor deposition, peri-receptor factors, and inflammatory mediators, and establish the prognosis for recovery in these patients; 2) Prospectively evaluate the inflammatory impact of chronic inhalant exposure to chemicals and particulates on nasal chemosensory function, explore mechanisms of action, and use computational models of air flow to predict olfactory function following changes in nasal structure; 3) Document the magnitude, quality and time course for changes in taste perception following radiation treatment for oral cancer, and explore the bases for disruption and the prognosis for recovery, through the examination of the impact of inflammatory factors on gustatory tissue at the molecular and cellular levels. Thus, in each of the three Projects the role of inflammatory factors in mediating sensory loss and recovery will be investigated. Tying these projects together through patient recruitment, common psychophysical and medical assessment, and coordination of database management and statistical evaluation is the Sensory/Medical Core. This Core will also continue to evaluate patients referred with primary complaints of chemosensory dysfunction in order to identify additional questions of clinical interest and to refine hypotheses concerning the nature, bases and implications of those dysfunctions.

描述（由申请人提供）：要求资金支持Monell-Jefferson化学体临床研究中心CCRC中的新项目）。该CCRC涉及Monell化学感官中心的科学家与托马斯·杰斐逊大学的医师之间的合作。宾夕法尼亚大学，其他几所大学以及费城退伍军人事务医学中心也与宾夕法尼亚大学的医生和科学家合作。它致力于对口味，气味和化学刺激中临床疾病的科学检查。通过对临床人群的多学科研究，CCRC科学家的目标是表征和理解化学感应功能中疾病的病因，提供有关人类化学感官的机制和功能的信息，并制定与化学体障碍治疗/应对的策略。 CCRC需要一个行政核心部门，一个感官/医疗核心单元和三个个人但高度相互关联的研究项目。这三个项目中的每个项目的总体目标是：1）评估慢性鼻腔内苏脂蛋白患者的因果因素降低的因素，例如空气流量和气味沉积的改变，受感受器的因素和炎症介体的改变，并确定这些患者康复的预后； 2）前瞻性评估慢性吸收性物质和微粒对鼻化学感应功能的炎症影响，探索作用机制，并使用空气流量的计算模型来预测鼻结构变化后的嗅觉功能； 3）记录口腔癌放射治疗后味觉感知的变化的大小，质量和时间过程，并通过检查炎症因子对分子和细胞水平上的味道组织的影响，探索破坏和恢复预后的基础。因此，将研究三个项目中的每个项目中炎症因素在介导感觉丧失和恢复中的作用。通过招聘患者，常见的心理物理和医学评估以及数据库管理和统计评估的协调将这些项目捆绑在一起。该核心还将继续评估引用化学感应功能障碍的主要投诉的患者，以确定其他有关这些功能障碍的性质，基础和含义的假设的其他问题。