Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence

青春期的压力、神经发育和成瘾行为的出现

基本信息

批准号：
7874688
负责人：
HILARY Patricia BLUMBERG
金额：
$ 24.11万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7874688
关键词：
Accidents Addictive Behavior Adolescence Adolescent Adolescent Medicine Adult Age Alcohol consumption Amygdaloid structure Attention Behavior Behavior Control Behavioral Biogenic Amines Biological Biological Factors Biology Birth Brain Cause of Death Child Child Abuse and Neglect Childhood Cognition Collaborations Data Development Diffusion Diffusion Magnetic Resonance Imaging Discipline Early treatment Eating Emotional Face Functional Magnetic Resonance Imaging Functional disorder Future Genes Genetic Genetic Variation Genotype Hyperphagia Image Image Analysis Impulsivity Intervention Laboratories Link Literature Magnetic Resonance Imaging Measures Medical Mental disorders Metabolic Modality Modeling Morbidity - disease rate Neurobiology Neurophysiology - biologic function Neuropsychology Neurosecretory Systems Pediatrics Pharmacology Physiological Prefrontal Cortex Prevention Principal Investigator Process Psychiatry Psychology Psychopathology Psychosocial Assessment and Care Psychosocial Factor Recording of previous events Recruitment Activity Regulation Research Research Personnel Risk Risk Factors Sampling Smoking Social Behavior Stimulus Stress Suicide Support System System Teenagers Temperament Testing Variant Ventral Striatum Violence Women&apos s Health addiction age group alcohol misuse base biological adaptation to stress biopsychosocial cognitive control cohort critical period driving behavior emotional stimulus environmental stressor experience gene interaction girls hedonic high risk human subject imaging modality innovation maltreatment model development mortality motivated behavior multimodality neural circuit neurodevelopment neuroimaging novel prenatal promoter relating to nervous system response serotonin transporter stressor white matter young adult

项目摘要

Stress, Neurodevelppment and the Emergence of Addictive Behaviors in Adolescence (Project 6 of 14): Adolescence is a critical period for the emergence of addictive behaviors that not only place adolescents at immediate risk for morbidity and for accidents, suicide, and violent behavior (the leading causes of death in this age group), but also contribute to lifelong increases in major medical morbidity and early mortality. Though childhood stress is known to be a major risk factor for the development of addictive behaviors in adolescence, there is a paucity of study of the mechanisms by which stress leads to the emergence of addictive behaviors in teens. Our pilot data suggest that childhood stress alters development of ventral prefrontal cortex (VPFC) control over amygdala and ventral striatum responses to emotional stimuli, resulting in excessive drive towards hedonic stimuli, impulsivity and addictive behaviors. This project establishes a new collaboration between co-Pis Drs. Blumberg and Mayes to bring together their respective expertise in multimodality magnetic resonance imaging (MRI) study of adolescent brain development and modeling the influences of psychosocial factors on the development of adaptive emotional and social behaviors in children and adolescents. This will provide unique opportunities to study how psychosocial stressors in childhood alter cortico-limbic development to contribute to the emergence of addictive behaviors in adolescence. This study team will include Drs. Kalmar, Mazure, Nicholls, Nolen-Hoeksema, Ryan, Wang and other consortium collaborators to integrate perspectives including Adolescent Medicine, Neurobiology, Neuroimaging, Neuropsychology, Pediatrics, Psychiatry, Psychology and Women's Health. Dr. Mayes has followed a unique cohort prospectively since birth, now entering adolescence, carefully characterized with biannual assessments for biopsychosocial factors. We plan to study 70 adolescents from this cohort, ages 14-17 years (50% girls): 35 with a history of childhood maltreatment and 35 without a history of maltreatment. Dr. Blumberg's group will perform functional MRI and diffusion tensor imaging to examine regional brain response to emotional stimuli within cortico-limbic circuitry, the functional connectivity between components within this circuitry, as well as the integrity of the structural white matter connections in the circuitry. Consortium core (Projects 13,14) measures of stress, biological factors and addictive behaviors will provide rich opportunities for study, including interactions between stress and genetic variations associated with biogenic amine regulation of the amygdala-ventral striatum-VPFC neural system (as in 2,3,7,8) in influencing the emergence of addictive behaviors. Collaboration with Drs. Potenza and Neumeister (7,8) will provide opportunities to examine similarities and differences between adolescents and adults, and novel treatments tested (5,9,10) will provide the basis for future innovative prevention and early intervention strategies.

青春期的压力、神经发育和成瘾行为的出现（项目 6，共 14 个）：青春期是成瘾行为出现的关键时期，这不仅使青少年陷入成瘾行为发病、事故、自杀和暴力行为（死亡的主要原因）的直接风险这个年龄组），但也导致主要医疗发病率和早期死亡率的终身增加。尽管众所周知，童年压力是成瘾行为发展的主要危险因素青春期时，对于压力导致出现问题的机制的研究还很少。青少年的成瘾行为。我们的试验数据表明，童年压力会改变腹侧的发育前额皮质（VPFC）控制杏仁核和腹侧纹状体对情绪刺激的反应，从而产生过度追求享乐刺激、冲动和成瘾行为。该项目建立了一个 Pis 博士之间的新合作。 Blumberg 和 Mayes 汇集各自的专业知识青少年大脑发育的多模态磁共振成像 (MRI) 研究和建模心理社会因素对儿童适应性情绪和社会行为发展的影响和青少年。这将为研究儿童时期的社会心理压力源提供独特的机会改变皮质边缘发育，导致青春期成瘾行为的出现。这研究小组将包括博士。 Kalmar、Mazure、Nicholls、Nolen-Hoeksema、Ryan、Wang 等财团合作者整合包括青少年医学、神经生物学、神经影像学在内的观点，神经心理学、儿科、精神病学、心理学和妇女健康。梅耶斯博士遵循独特的从出生开始前瞻性队列，现在进入青春期，每年两次仔细表征生物心理社会因素的评估。我们计划研究该队列中 70 名 14-17 岁的青少年岁（50% 女孩）：35 岁有童年虐待史，35 岁无虐待史。博士。布隆伯格的小组将进行功能性核磁共振和扩散张量成像来检查区域大脑皮质边缘回路内对情绪刺激的反应，组件之间的功能连接该电路内，以及电路中结构性白质连接的完整性。联盟核心（项目 13,14）压力、生物因素和成瘾行为的测量将提供丰富的研究机会，包括压力与相关遗传变异之间的相互作用杏仁核-腹侧纹状体-VPFC神经系统（如2、3、7、8）的生物胺调节影响成瘾行为的出现。与博士的合作。波坦察 (Potenza) 和纽迈斯特 (Neumeister) (7,8) 将提供有机会检查青少年和成人之间的相似性和差异以及新的治疗方法经过测试（5,9,10）将为未来创新预防和早期干预策略提供基础。