Locomotor Adaptations Following Stroke

中风后的运动适应

基本信息

批准号：
7802208
负责人：
DARCY S. REISMAN
金额：
$ 13.23万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-20 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7802208
关键词：
3-Dimensional Affect Animals Brain Stem Cerebellum Characteristics Clinical Clinical Trials Data Effectiveness Energy Metabolism Functional disorder Gait Goals Human Individual Knowledge Laboratories Leg Limb structure Locomotion Locomotor adaptation Measurement Measures Mentors Mentorship Motor Movement Nervous System Trauma Patients Pattern Performance Persons Preparation Process Production Randomized Clinical Trials Reading Recovery Rehabilitation therapy Relative (related person)Research Research Training Series Speed Spinal Cord Stimulus Stroke Structure Survivors Testing Training Training Programs Translating Visual Walking Work auditory feedback base clinical practice design disability experience flexibility hemiparesis improved insight investigator training lectures meetings neural circuit neuromechanism novel post stroke research study

项目摘要

DESCRIPTION (provided by applicant): The goal of the proposed research is to understand the capacity of persons with post-stroke hemiparesis to adapt locomotor interlimb coordination and the influence of this on gait symmetry. Utilizing this knowledge, the applicant's long-term research goal is to develop scientifically-based therapies to advance the physical rehabilitation and recovery of locomotion in persons following a stroke. A five-year research and training plan has been developed to meet these goals. This plan consists of training in the neural mechanisms of locomotion, motor adaptations in persons with neurological damage, gait measurement and analysis and the design and implementation of randomized clinical trials in rehabilitation. This plan will be implemented under the mentorship of the primary mentor, an expert in motor adaptation in persons with neurological damage and the cosponsor, an expert in the analysis of walking in persons with gait dysfunction and in the design and implementation of clinical trials in rehabilitation. Training will consist of structured readings, attendance at course lectures and seminars, structured laboratory experiences and presentation at academic meetings. With complete support from the candidate's department chair, the candidate will have access to two fully equipped laboratories capable of measuring 3-dimensional human movement and force production. The proposed research will test the general hypothesis that persons with post-stroke hemiparesis are able to adapt their locomotor patterns following walking on a split-belt treadmill, where each leg is moved at a different speed. It is hypothesized that the adapted pattern of interlimb coordination following split-belt treadmill locomotion may be used to improve gait symmetry and function in persons post-stroke. Specific aims will test: 1) the capacity of persons with post-stroke hemiparesis to adapt interlimb coordination, 2) the generalization of adapted patterns to overground locomotion and, 3) the feasibility of using split-belt treadmill training to improve gait symmetry in persons post-stroke. Relevance: Of the 700,000 persons affected by stroke each year, 50% will continue to demonstrate long term walking dysfunction, some caused by poor coordination between the legs. This research investigates the potential of a novel type of treadmill walking to influence coordination between the legs in persons who have sustained a stroke.

描述（由申请人提供）：拟议研究的目标是了解中风后偏瘫患者适应肢体间运动协调的能力及其对步态对称性的影响。利用这些知识，申请人的长期研究目标是开发基于科学的疗法，以促进中风后患者的身体康复和运动恢复。为了实现这些目标，我们制定了五年研究和培训计划。该计划包括运动神经机制的培训、神经损伤患者的运动适应、步态测量和分析以及康复随机临床试验的设计和实施。该计划将在主要导师（神经损伤患者运动适应专家）和共同发起者（步态功能障碍患者行走分析专家以及康复临床试验设计和实施方面的专家）的指导下实施。培训将包括结构化阅读、参加课程讲座和研讨会、结构化实验室体验以及学术会议上的演讲。在候选人系主任的全力支持下，候选人将可以使用两个设备齐全的实验室，能够测量 3 维人体运动和力的产生。拟议的研究将检验以下一般假设：中风后偏瘫患者在分体带跑步机上行走后能够适应其运动模式，其中每条腿以不同的速度移动。据推测，分体带跑步机运动后肢体间协调的适应模式可用于改善中风后患者的步态对称性和功能。具体目标将测试：1）中风后偏瘫患者适应肢体间协调的能力，2）将适应模式推广到地上运动，3）使用分体带跑步机训练来改善人步态对称性的可行性中风后。相关性：每年有 700,000 名中风患者，其中 50% 的人将继续表现出长期行走功能障碍，其中一些是由于双腿之间的协调性不佳引起的。这项研究调查了一种新型跑步机行走对中风患者双腿协调性影响的潜力。