Data and Resource Coordination Center for Cancer Prevention-Interception Targeted Agent Discovery Program

癌症预防拦截靶向药物发现计划数据和资源协调中心

基本信息

批准号：
10796105
负责人：
Alan David Hutson
金额：
$ 77.12万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10796105
关键词：
Acceleration Address Adopted Bioconductor Bioinformatics Biometry Cancer Center Cancer Center Support Grant Catalogs Characteristics Collaborations Communities Comprehension Computer software Data Data Analyses Data Coordinating Center Data Science Databases Development Ecosystem Ensure Fostering Funding Goals Hand Immune Targeting Immunooncology Immunotherapy Informatics Information Technology Infrastructure Intercept Malignant Neoplasms Methods Molecular Target Multiomic Data National Human Genome Research Institute Oncogenic Police Policies Principal Investigator Process Productivity PubMed Records Reproducibility Research Research Personnel Research Project Grants Resistance Resource Sharing Resources Risk Services Text United States National Institutes of Health Visualization biomedical informatics cancer prevention central database cloud based community engagement data acquisition data ecosystem data harmonization data integration data management data sharing data sharing networks data standards design experience genomic data high risk population improved innovation interest interoperability multidisciplinary open source operation outreach pre-clinical precision cancer prevention prevent programs quality assurance response support network targeted agent therapy resistant tool translational oncology translational study tumor progression virtual

项目摘要

Project Summary/Abstract: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-23-012. The goal of our proposed Data and Resource Coordinating Center (DRCC) application is to coordinate the activities across the Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the CAP-IT to discover molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process for precision cancer prevention and interception. Our strategy is to enhance the productivity of CAP-IT investigators by fostering a collaborative and synergistic research community, accelerate the progress of CAP- IT research by reducing barriers to accessing analytics expertise, ensure the reproducibility of CAP-IT data by deploying best practices for data acquisition and harmonization, and unleash the full potential of CAP-IT activities by developing enhanced tools to enable resource sharing to the broader scientific community. First, we will provide a centralized administrative infrastructure to coordinate CAP-IT activities, building upon our well-functioning infrastructure that currently coordinates network studies under the umbrella of the NCI Cancer Moonshot initiatives. Second, we will actively promote the CAP-IT and engage in trans-consortium interactions, where we will leverage our demonstrable experience in Cross-Moonshot outreach and Bioconductor’s decades-long record in community engagement. Third, we will, in coordination with each CAP- IT center’s informatics group, provide multidisciplinary analytics expertise to support CAP-IT’s collaborative research, leveraging three of Roswell Park CCSG’s shared resources: Biostatistics, Bioinformatics, Biomedical Informatics. Fourth, we will develop improved data integration and analysis software, database and workflows to enhance CAP-IT’s research capacity, capitalizing on our extensive track-record in developing NIH-supported Cancer Moonshot, Bioconductor and AnVIL ecosystems. Taken together, we envision that our DRCC, in close collaboration with the CAP-IT U54 Centers and NCI staffs, will allow us to support highly effective and innovative translational studies to address the significantly unmet needs related to precision cancer prevention-interception. The main deliverables from the proposed aims will be administrative and outreach support to coordinate network activities, facilitate network collaboration, and engage in interaction with the broader community (Aim 1); workflows to ensure that all data generated by the CAP-IT will be harmonized using standards interoperable with the broader cancer data ecosystem, analysis tools and database to integrate CAP-IT data and facilitate cross-study analysis, and multidisciplinary analytics supports to accelerate CAP-IT research progress (Aim 2); polices and infrastructures to ensure that all resources generated by the CAP-IT will be findable in a centralized virtual information hub, and that all resources will be shared with the broader scientific community (Aim 3).

项目摘要/摘要：本申请是为了响应特别通知而提交的。兴趣 (NOSI) 确定为 NOT-CA-23-012 我们提议的数据和资源协调中心的目标。（DRCC）应用程序是为了协调整个癌症预防-拦截靶向药物的活动发现计划（CAP-IT），并管理、整合和传播所生成的数据和资源通过网络利用尖端的多学科团队方法，我们将支持 CAP-IT 发现旨在预防或拦截致癌过程的分子或免疫靶向药物我们的策略是提高 CAP-IT 的生产力。研究人员通过培养协作和协同的研究社区，加速 CAP 的进展 IT 研究通过减少获取分析专业知识的障碍，确保 CAP-IT 数据的可重复性部署数据采集和协调的最佳实践，并释放 CAP-IT 活动的全部潜力通过开发增强的工具来实现更广泛的科学界的资源共享。首先，我们将提供一个集中的管理基础设施来协调 CAP-IT 活动，建立建立在我们运作良好的基础设施之上，该基础设施目前在 NCI 的保护下协调网络研究其次，我们将积极推动 CAP-IT 并参与跨联盟。互动，我们将利用我们在 Cross-Moonshot 推广方面的明显经验，第三，Bioconductor 在社区参与方面拥有数十年的记录，我们将与每个 CAP 协调。 IT 中心的信息学小组提供多学科分析专业知识来支持 CAP-IT 的协作研究，利用罗斯威尔公园 CCSG 的三个共享资源：生物统计学、生物信息学、生物医学第四，我们将开发改进的数据集成和分析软件、数据库和工作流程。增强 CAP-IT 的研究能力，利用我们在开发 NIH 支持的方面的广泛记录 Cancer Moonshot、Bioconductor 和 AnVIL 生态系统结合在一起，我们设想我们的 DRCC 会紧密结合。与 CAP-IT U54 中心和 NCI 工作人员的合作，将使我们能够支持高效和创新转化研究，旨在解决与精准癌症预防拦截相关的显着未满足的需求。拟议目标的主要成果将是行政和外展支持，以协调网络活动，促进网络协作，并与更广泛的社区进行互动（目标 1) 确保 CAP-IT 生成的所有数据都使用可互操作的标准进行协调的工作流程与更广泛的癌症数据生态系统、分析工具和数据库集成 CAP-IT 数据并促进交叉研究分析和多学科分析支持加速 CAP-IT 研究进展（目标 2）；政策和基础设施，以确保 CAP-IT 生成的所有资源都可以在一个集中的地方找到虚拟信息中心，所有资源将与更广泛的科学界共享（目标 3）。