BSL3 management and practice of infectious disease research at HTRL

HTRL 传染病研究的 BSL3 管理和实践

基本信息

批准号：
10793948
负责人：
JOSEPH A. KANABROCKI
金额：
$ 246.91万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10793948
关键词：
2019-nCoV Accidents Air Animal Model Antibiotic Therapy Antibiotics Articulation Awareness Bacteria Bacterial Infections Biological Biological Assay Biomedical Research Bioterrorism Birds COVID-19 COVID-19 pandemic Certification Chicago Classification Clostridium difficile Collaborations Communicable Diseases Communities Containment Coronavirus Country Decontamination Dedications Dengue Development Disease Doctor of Philosophy Ebola virus Economics Emergency Situation Emerging Communicable Diseases Engineering Environment Environmental Health Epidemic Equilibrium Evaluation Event Financial Support Fostering Frequencies Funding Opportunities Genome Goals Health Human Human Resources Immune response Immunity In Vitro Infection Infectious Agent Infectious Diseases Research Influenza Institution Investigation Knowledge Laboratories Laboratory Personnel Leadership Livestock Maintenance Mammals Measures Medical Microbe Microbiology Middle East Respiratory Syndrome Coronavirus Modeling Molecular Morbidity - disease rate Mutation National Institute of Allergy and Infectious Disease Operations Research Panic Pathogenicity Persons Pharmaceutical Preparations Population Preventive Procedures Protective Devices Protocols documentation Public Health RNA Viruses Regulation Research Research Activity Research Support Resources Risk Role SARS coronavirus Safety Scientist Secure Services Societies Structure System Technology Testing Therapeutic Intervention Toxin Training Training Activity Training and Education Training and Infrastructure Universities Vaccines Variant Viral Virulence Virus ZIKA Zoonoses biodefense biosafety level 3 facility biosecurity chikungunya combat companion animal cost drug resistant pathogen hazard human disease improved in vivo insight medical countermeasure meetings methicillin resistant Staphylococcus aureus microbial operation pathogen pathogenic microbe prevent preventive intervention professor public health emergency repaired response transmission process viral outbreak virtual web portal

项目摘要

PROJECT ABSTRACT (OVERALL) Our nation’s ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and understanding human immune responses to infection. Following bioterrorism events in 2001, the National Institute of Allergy and Infectious Diseases established the Regional Biocontainment Laboratory (RBL) Network, to promote safe research in 12 Biosafety Level 3 (BSL3) laboratories. In turn, Institutions and Universities hosting these RBLs sustained the management of these facilities, fostered a strong Biosafety culture, and fueled research inquiries into the molecular mechanisms whereby microbes cause human disease. The University of Chicago hosts the Regional Biocontainment Howard Taylor Ricketts Laboratory (HTRL) operated by its Department of Microbiology since 2009. When this nation began to implement shutdowns to prevent the spread of COVID-19, essential professionals at the HTRL continued key management operations and pivoted their expertise to study SARS-CoV2. This momentum would not have been possible without the existing expertise and dedication of engineers, biosafety officers, veterinary staff, scientists, as well as financial support from the University. The goal of this proposal is to present a plan to maintain the safe operation and management of the BSL3 space of the Regional Biocontainment HTRL and to continue training professionals who will provide research support services for the development of measures necessary to mitigate and protect the public's health from infectious diseases that may be the result of intentional, accidental, or naturally occurring health emergency. This plan will be implemented by three cores. Core 1 Facility Management, Maintenance and Operations (C1Facilities@HTRL) led by George Langan, describes activities that support continuous BSL3 containment through decontamination, retesting, certification, preventive maintenance, repair or replacement of building systems and compliance with Biosecurity, Environmental Health, and Biosafety regulations. Core 2 BSL3 Practices (C2BSL3Practice@HTRL) led by Joseph Kanabrocki, describes activities for the training of personnel and the development of Standard Operating Procedures as well as activities to sustain a safe and secure environment. Core 3 Biocontainment Research Support Services (C3ResearchSupport@HTRL) led by Dominique Missiakas, describes research capabilities for the study of Risk Group 3 and Select Agent pathogens. HTRL will use a web-based portal to advertise and offer research services such as isolation and characterization of pathogens, virulence and countermeasure studies using in vitro and in vivo assays and animal models. Monthly virtual and annual in-person meetings between RBL Directors will identify opportunities for collaborations, improvements, and cross-training. These interactions will expand the capacity of the RBL network as a whole to respond to public health emergencies, conduct evaluations of threats and countermeasures, and provide education and training to conform with biosafety standards.

项目摘要（总体）我们国家发现、预防和打击生物恐怖主义和新发传染病的能力取决于通过对致病微生物的生物医学研究和理解而产生的技术 2001 年生物恐怖主义事件后，国家过敏研究所研究了人类对感染的免疫反应。和传染病建立了区域生物防护实验室（RBL）网络，以促进安全 12 个生物安全 3 级 (BSL3) 实验室的研究，以及托管这些 RBL 的机构和大学。持续管理这些设施，培育强大的生物安全文化，并推动研究调查芝加哥大学主办了微生物引起人类疾病的分子机制。区域生物防护霍华德·泰勒·里基茨实验室 (HTRL)，由其部门运营自 2009 年以来的微生物学。当这个国家开始实施封锁以防止 COVID-19 传播时， HTRL 的重要专业人员继续进行关键管理运营，并将他们的专业知识用于学习如果没有 SARS-CoV2 现有的专业知识和奉献精神，这种势头是不可能实现的。工程师、生物安全官员、兽医人员、科学家以及大学的财政支持。该提案的目标是提出一项计划，以维持 BSL3 空间的安全运营和管理区域生物防护 HTRL 并继续培训提供研究支持的专业人员制定必要措施以减轻和保护公众健康免受传染病侵害的服务可能因故意、意外或自然发生的健康紧急情况而导致的疾病。将由三个核心实施：核心 1 设施管理、维护和运营。 (C1Facilities@HTRL) 由 George Langan 领导，描述了支持持续 BSL3 遏制的活动通过净化、重新测试、认证、预防性维护、修理或更换建筑物系统并遵守生物安全、环境健康和生物安全核心 2 BSL3 法规。由 Joseph Kanabrocki 领导的实践 (C2BSL3Practice@HTRL) 描述了培训活动人员和标准操作程序的制定以及维持安全和安全的活动安全环境。核心 3 生物防护研究支持服务 (C3ResearchSupport@HTRL) 由 Dominique Missiakas 领导，描述了风险组 3 和选择代理的研究能力 HTRL 将使用基于网络的门户网站来宣传并提供研究服务，例如隔离和治疗。使用体外和体内测定法表征病原体、毒力和对策研究 RBL 董事之间的每月虚拟会议和年度面对面会议将确定动物模型。这些互动将扩大能力。 RBL 网络作为一个整体来应对突发公共卫生事件、进行威胁评估和对策，并提供符合生物安全标准的教育和培训。