Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH

通过 IUB-SPH 的指导培训经验促进 DEIA 在肺部疾病研究中的应用

基本信息

批准号：
10792180
负责人：
Patricia Silveyra
金额：
$ 39.62万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-10 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10792180
关键词：
Accounting Administrative Supplement Adverse effects Affect Agonist Air Allergens Allergic inflammation Androgen Receptor Androgens Animal Model Anti-Inflammatory Agents Asthma Award Biological Cells Cementation Development Diagnosis Disparity Elements Environmental Exposure Environmental Risk Factor Epithelial Cells Epithelium Estradiol Estrogen Receptors Estrogens Estrous Cycle Exposure to Female Four Core Genotypes Funding Gender Gene Expression Gene Expression Profile Genetic Transcription Goals Gonadal Hormones Gonadal Steroid Hormones Graduate Education Growth Factor Harvest Health Hormone Receptor Hormones Human Immune Immunology Indiana Individual Individual Differences Inflammation Inflammatory Inflammatory Response Inhalation Institution Internships Investigation Knowledge Laboratories Leadership Life Liquid substance Lung Lung diseases Mediating Mentors Mentorship Mission Modeling Molecular Morbidity - disease rate National Heart, Lung, and Blood Institute Outcome Parents Participant Pathway Analysis Patients Persons Phase Physiological Predisposition Prevalence Prevention Process Progesterone Progesterone Receptors Program Development Puberty Public Health Public Health Schools Pulmonary Inflammation Pyroglyphidae RNA Reporting Research Research Priority Research Project Grants Research Training Respiratory Disease Risk STEM field STEM research Science Severities Sex Chromosomes Sex Differences Signal Transduction Stanolone Stimulus Students System Testing Training Training Programs Training Technics United States Universities Woman Work airway epithelium antagonist asthma exacerbation asthmatic asthmatic patient bronchial epithelium career career awareness career development chemokine cohort cytokine design equity, diversity, and inclusion experience experimental study female sex hormone in vivo inflammatory lung disease leadership development male male sex hormones men middle age mouse model multiplex assay novel prevent programs protein biomarkers protein expression pulmonary function pulmonary symptom receptor recruit response sex specific biomarkers summer research technology platform undergraduate student virtual

项目摘要

PROJECT SUMMARY This Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship proposal expands on the research goals of parent study and its associated diversity supplement, which aim to a) investigate the mechanisms by which gonadal sex hormones contribute to asthma development and progression, and b) discover basic biological differences underlying the influence of sex and gender in asthma presentation and outcomes. If funded, this supplement award will provide support for 10 undergraduate student trainees to help conduct this research and participate in a culturally relevant leadership development and research training program. The specific activities of this administrative supplement will support DEIA by supporting the career development of a cohort of students from traditionally underrepresented backgrounds in STEM fields, while expanding the research goals of the parent award. This will be accomplished by 1) building student awareness of career opportunities, 2) increasing student knowledge of the science research/discovery process, 3) cementing individual resolve, perseverance and confidence in students, and 4) exposing students to a variety of professionals from a multitude of backgrounds in public health to expand their options for career selection. Specifically, a cohort of 10 students from institutions across the United States, and from backgrounds underrepresented in STEM, will be recruited for an integrated leadership development and research training program at Indiana University Bloomington School of Public Health (IUB-SPH). The first phase of the program will focus on cohort-building activities that will be conducted virtually over 3-months, and include elements of career development training that will prepare them for a summer research experience. The second phase of the program will consist of an 8-week in-person summer research intensive experience at IUB-SPH, where students will participate in a) an intensive in-person individual leadership development program, b) a hands-on laboratory techniques training, c) the completion of an independent research project aimed to characterize sex differences in pro-inflammatory gene expression triggered by allergen exposure in primary human bronchial epithelial cells, as well as to detect novel sex- specific protein biomarkers for allergic inflammation in the lung epithelium using an immunology multiplex analysis technology platform. Similar to the parent award and its associated diversity supplement, this administrative supplement is well-aligned with the research priorities of NHLBI by investigating pathobiological mechanisms important to the onset and progression of lung diseases, identifying factors that account for individual differences in lung disease pathobiology, including sex differences and the influence of sex, and developing, diversifying, and sustaining a scientific workforce capable of accomplishing the institute’s mission.

项目概要本行政补充文件旨在表彰在多样性、公平性、包容性和可及性方面的卓越表现 (DEIA) 指导提案扩展了家长研究的研究目标及其相关多样性补充品，其目的是 a) 研究性激素导致哮喘的机制发育和进展，以及 b) 发现性别和性别影响下的基本生物学差异如果获得资助，该补充奖将为 10 名患者提供支持。本科生学员帮助进行这项研究并参与文化相关的领导活动本行政补充文件的具体活动将包括开发和研究培训计划。通过支持传统上代表性不足的学生群体的职业发展来支持 DEIA STEM 领域的背景，同时扩大家长奖项的研究目标。通过 1) 培养学生对职业机会的认识，2) 增加学生对职业机会的了解科学研究/发现过程，3) 巩固个人的决心、毅力和信心学生，以及 4) 让学生在公共场合接触来自多种背景的各种专业人士具体来说，是来自各院校的 10 名学生。来自美国且在 STEM 领域代表性不足的背景的人员将被招募来进行综合培训印第安纳大学伯明顿公立学院领导力发展和研究培训项目健康（IUB-SPH）。该计划的第一阶段将重点开展队列建设活动。几乎超过 3 个月，其中包括职业发展培训的内容，帮助他们为未来的职业发展做好准备该计划的第二阶段将包括为期 8 周的夏季研究体验。在 IUB-SPH 进行研究密集型体验，学生将参加 a) 密集型面对面学习个人领导力发展计划，b) 实验室技术实践培训，c) 完成一个独立的研究项目，旨在表征促炎基因表达的性别差异由原代人支气管上皮细胞中的过敏原暴露触发，以及检测新的性别使用多重免疫学方法确定肺上皮过敏性炎症的特异性蛋白质生物标志物与母奖及其相关的多样性补充类似，该分析技术平台。通过调查病理生物学，行政补充与 NHLBI 的研究重点非常一致肺部疾病发生和进展的重要机制，确定影响肺部疾病发生和进展的因素肺部疾病病理学的个体差异，包括性别差异和性别的影响，以及发展、多样化和维持一支能够完成研究所使命的科学队伍。