Quantitative Ultrasound for Assessment of Placental Structure During the Development of Preeclampsia

定量超声评估先兆子痫发展过程中的胎盘结构

• 批准号: 10790437
• 负责人: Carolyn Louise Bayer
• 金额: $ 44.26万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10790437
• 关键词: Acute; Blood Vessels; Blood flow; Clinic; Clinical; Clinical assessments; Decidua; Dedications; Development; Diagnosis; Discipline of obstetrics; Disease Progression; Doppler Ultrasound; Early Diagnosis; Early Intervention; Elasticity; Endometrium; Etiology; Fetal health; Fibrosis; First Pregnancy Trimester; Funding; Funding Opportunities; Future; Goals; Growth; Health; Histopathology; Human; Image; Imaging Device; Injury; Invaded; Knowledge; Magnetic Resonance Imaging; Maternal Health; Medical Imaging; Medicine; Methods; Mission; Modeling; New York; Outcome; Patient-Focused Outcomes; Perfusion; Placenta; Placental Insufficiency; Placentation; Pre-Eclampsia; Pregnancy; Prevention; Process; Property; Proteinuria; Public Health; Rattus; Research; Resolution; Resources; Risk; Rodent Model; Screening procedure; Severities; Signal Transduction; Structure; System; Testing; Time; Tissues; Ultrasonography; United States National Institutes of Health; Universities; Uterus; Validation; Woman; Work; attenuation; clinical translation; cost; effective therapy; elastography; endothelial dysfunction; fetal; imaging modality; improved; improved outcome; in vivo; in vivo imaging; maternal hypertension; novel; novel strategies; point of care; pressure; quantitative ultrasound; radio frequency; response; soft tissue; statistics; success; tissue injury; tool; ultrasound

PROJECT SUMMARY A lack of effective treatments for preeclampsia persists due, in part, to our inability to detect altered placental tissue microstructure as an indicator of abnormal placental development. This application proposes a MPI collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY and Tulane University (TU) in New Orleans, LA. The proposed project is responsive to the Human Placenta Project PAR-22-236 and seeks to develop a novel ultrasound approach for “safe, real-time, and non-invasive” assessment of “the development … of the human placenta across pregnancy”. Our long-term goal is to develop imaging tools to improve outcomes in women with preeclampsia. The overall objective of this proposal is to develop and validate quantitative ultrasound (QUS) to detect and correlate microstructural alterations in the placenta with preeclampsia. QUS uses radio-frequency (RF) US signals to characterize soft tissues quantitatively. We hypothesize that QUS-based parameters will be capable of quantifying the microstructural changes which characterize preeclampsia. Guided by a strong scientific premise, this hypothesis will be tested by pursing two specific aims: 1) To quantify altered human placental microstructure ex vivo; and 2) To assess placental microstructure longitudinally in vivo in an established rodent model of preeclampsia. Under the first aim, we will develop QUS methods to characterize the human placenta and test the hypothesis that specific QUS parameters will correlate with altered vascular development and injury in the ex vivo human preeclamptic placenta, with histopathology as the gold standard. The second aim will test the hypothesis that QUS parameters will correlate with microstructural and changes due to altered vasculature and fibrosis in the reduced uterine perfusion pressure rat model of preeclampsia. The expected outcome of this work will be the validation of QUS-derived parameters for the assessment of placental microstructure. With these imaging methods, we anticipate correlating specific QUS parameters related to placental microstructure with the diagnosis of preeclampsia. This outcome will strongly motivate the dedication of additional resources for clinical translation and in vivo longitudinal validation of QUS to earlier detect and predict severity of preeclampsia in women. Consistent with the goals of this funding opportunity and the goals of the HPP, this work will lead to the development of a new point-of-care ultrasound assessment of preeclampsia risk and severity, which can be accomplished using the ultrasound systems existing in the clinic.

项目概要 先兆子痫仍然缺乏有效的治疗方法，部分原因是我们无法检测胎盘的改变 组织微观结构作为异常胎盘发育的指标本申请提出了 MPI。 纽约威尔康奈尔医学院 (WCM) 和杜兰大学将进行合作研究 （TU），路易斯安那州新奥尔良 拟议项目响应人类胎盘项目 PAR-22-236。 并寻求开发一种新颖的超声方法，用于“安全、实时和非侵入性”评估“ 怀孕期间人类胎盘的发育……我们的长期目标是开发成像工具 改善先兆子痫女性的预后 该提案的总体目标是制定和实施。 验证定量超声 (QUS) 检测胎盘微观结构变化并将其与 QUS 使用射频 (RF) US 信号来定量表征软组织。 基于 QUS 的参数将能够量化微观结构的变化， 在强有力的科学前提的指导下，这一假设将得到检验。 两个具体目标：1) 量化体外胎盘微观结构的改变；2) 评估胎盘 在第一个目标下，我们在已建立的先兆子痫啮齿动物模型中纵向观察体内微观结构。 将开发 QUS 方法来表征人类胎盘并测试特定 QUS 的假设 参数将与离体人类先兆子痫的血管发育和损伤的改变相关 胎盘，以组织病理学为金标准，第二个目标将检验 QUS 的假设。 参数将与微观结构以及由于脉管系统和纤维化改变而引起的变化相关 子痫前期子宫灌注压降低大鼠模型这项工作的预期结果是。 通过这些成像来验证 QUS 衍生参数用于评估胎盘微观结构。 方法，我们预计将与胎盘微观结构相关的特定 QUS 参数与 这一结果将强烈激励我们投入更多资源。 QUS 的临床转化和体内纵向验证，可及早检测和预测疾病的严重程度 女性先兆子痫与本次资助机会的目标和 HPP 的目标一致。 这项工作将导致开发一种新的针对先兆子痫风险的护理点超声评估 严重程度，这可以使用诊所现有的超声系统来完成。