A Population-Based Latinx Community Study of Alzheimer’s Disease

基于人群的阿尔茨海默氏病拉丁裔社区研究

基本信息

批准号：
10730066
负责人：
Kristin R Krueger
金额：
$ 55.34万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10730066
关键词：
Address Adult Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Behavioral Biological Biological Markers Black race Blood Blood specimen COVID-19 COVID-19 impact COVID-19 outbreak COVID-19 pandemic effects Censuses Chicago Clinical Cohort Studies Collection Communities Community Outreach Data Data Collection Death Rate Dementia Elderly Epidemic Ethnic Origin Ethnic Population Event Exhibits Focus Groups Future Genetic Goals Grant Growth Health Health system Height High Prevalence Hispanic Hispanic Populations Household Impaired cognition Incidence Individual Infrastructure Knowledge Latinx Latinx population Life Style Minority Minority Groups Neighborhoods Not Hispanic or Latino Participant Pathology Perception Persons Phase Population Population Study Prevalence Prevention strategy Procedures Protocols documentation Public Health Race Recommendation Research Research Infrastructure Research Project Grants Resource Sharing Resources Risk Risk Factors Sampling Side Testing U-Series Cooperative Agreements United States National Institutes of Health Update Washington apolipoprotein E-4 biracial cardiovascular risk factor clinical diagnosis cognitive function cognitive testing cohort community organizations design experience health determinants health inequalities human old age (65+)improved infection rate member mild cognitive impairment minority health minority health disparity multi-ethnic nervous system disorder novel population based population health psychologic psychosocial racial difference racial population recruit research study social social determinants success tool web site

项目摘要

ABSTRACT Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain vastly underrepresented in research studies to characterize risk factors associated with progressive cognitive decline. A better understanding of risk factors can provide better treatment and design appropriate preventive strategies for older Latinx adults. Since older Latinx adults have a higher prevalence of cardiovascular risk factors, their risk of developing ADRD is high in old age. Older Latinx communities were disproportionately affected by the COVID-19 pandemic, which can increase their risk for neurological disorders. This UH2/UH3 cooperative agreement aims to engage and develop the infrastructure for a new Latinx cohort study with the following aims: (1) build infrastructure, community outreach, and the external advisory board for a new Latinx cohort; (2) develop ongoing engagement with the community and resource sharing plan; (3) collect data on 250 Latinx participants from East Side sampling frame; and (4) test the exploratory hypotheses that Latinx participants have a higher prevalence of clinically diagnosed AD and MCI, and the impact of COVID-19 on AD is more severe compared to non-Hispanic whites, and the ApoE4 association with clinical AD and MCI is the same as NHW. The long-term objective is to perform a sizeable muti-ethnic study, combining the Latinx cohort with our existing Chicago Health and Aging Project (CHAP), a population-based community study in four neighborhoods with 10,801 participants with 63% non-Hispanic Black and 37% non-Hispanic white participants. This UH2/UH3 proposal will add a new Latinx cohort in the East Side community of Chicago, with over 60% Latinx. A multi-ethnic cohort will allow us to test several biological and psychosocial hypotheses of high public health significance. The collection of biospecimens will also allow for testing further blood biomarker hypotheses, developing an omics pipeline down the road, and providing additional infrastructure for pathology studies in a population-based cohort study with minorities.

抽象的美国的拉丁裔老年人患阿尔茨海默病 (AD) 及相关疾病的风险更大痴呆症（ADRD）。他们的认知能力下降速度比非西班牙裔白人更快。然而，他们仍然在描述与渐进性认知相关的风险因素的研究中，其代表性严重不足衰退。更好地了解危险因素可以提供更好的治疗并设计适当的预防措施针对老年拉丁裔成年人的策略。由于拉丁裔老年人的心血管风险较高因素，他们在老年时患 ADRD 的风险很高。较老的拉丁裔社区比例不成比例受到 COVID-19 大流行的影响，这可能会增加他们患神经系统疾病的风险。这个UH2/UH3 合作协议旨在与以下机构共同参与并开发一项新的拉丁裔队列研究的基础设施以下目标：(1) 为新拉丁裔建设基础设施、社区外展和外部咨询委员会队列； (2) 制定与社区的持续接触和资源共享计划； (3) 收集数据来自东区抽样框架的 250 名拉丁裔参与者； (4) 检验拉丁裔的探索性假设参与者临床诊断 AD 和 MCI 的患病率较高，以及 COVID-19 对 AD 的影响与非西班牙裔白人相比，这种情况更为严重，ApoE4 与临床 AD 和 MCI 的关联是与 NHW 相同。长期目标是进行一项大规模的多种族研究，结合拉丁裔队列与我们现有的芝加哥健康与老龄化项目 (CHAP) 一起，这是一项基于人口的社区研究，涉及四个国家有 10,801 名参与者的社区，其中 63% 为非西班牙裔黑人，37% 为非西班牙裔白人参与者。该 UH2/UH3 提案将在芝加哥东区社区增加一个新的拉丁裔群体，其中超过 60% 是拉丁裔。多种族队列将使我们能够测试一些生物学和心理社会假设具有高度的公共卫生意义。生物样本的收集还将允许进一步测试血液生物标志物假设，开发组学管道，并提供额外的基础设施少数群体基于人群的队列研究中的病理学研究。