Phase 2 Kp-10 in Patients with Hypogonadotropic Hypogonadism

低促性腺激素性性腺功能减退症患者的 2 期 Kp-10

• 批准号: 10730209
• 负责人: Stephanie Beth Seminara
• 金额: $ 65万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730209
• 关键词: Phase; Kp; 10; Patients; Hypogonadotropic

PROJECT ABSTRACT Patients with idiopathic hypogonadotropic hypogonadism (IHH) have insufficient GnRH secretion. The lack of endogenous GnRH leads to absent LH and FSH, resulting in suppression of ovarian and testicular function and decreased levels of estradiol and testosterone. The neuropeptide kisspeptin is a powerful stimulus for GnRH induced LH secretion. The goal of this study is to explore the effects of pulsatile kisspeptin to stimulate the hypothalamic GnRH neurons of patients with HH. Thus, this application, if funded, can facilitate the translation of this therapeutic potential to the clinic.

项目摘要 特发性低促性腺激素性性腺功能减退症 (IHH) 患者的 GnRH 分泌不足。缺乏 内源性 GnRH 导致 LH 和 FSH 缺失，从而抑制卵巢和睾丸功能， 雌二醇和睾酮水平降低。神经肽 Kisspeptin 对 GnRH 具有强大的刺激作用 诱导 LH 分泌。本研究的目的是探讨脉冲 Kisspeptin 刺激 HH 患者的下丘脑 GnRH 神经元。因此，如果获得资助，该应用程序可以促进翻译 将这种治疗潜力推向临床。